Zn Doping Improves the Anticancer Efficacy of SnO<sub>2</sub> Nanoparticles
Tin dioxide (SnO<sub>2</sub>) nanoparticles (NPs) can be applied in several ways due to their low cost, high surface-to-volume ratio, facile synthesis, and chemical stability. There is limited research on the biomedical application of SnO<sub>2</sub>-based nanostructures. Thi...
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MDPI AG
2023-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/22/12456 |
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| author | Sitah Alanazi ZabnAllah M. Alaizeri Rashid Lateef Nawal Madkhali Abdullah Alharbi Maqusood Ahamed |
| author_facet | Sitah Alanazi ZabnAllah M. Alaizeri Rashid Lateef Nawal Madkhali Abdullah Alharbi Maqusood Ahamed |
| author_sort | Sitah Alanazi |
| collection | DOAJ |
| description | Tin dioxide (SnO<sub>2</sub>) nanoparticles (NPs) can be applied in several ways due to their low cost, high surface-to-volume ratio, facile synthesis, and chemical stability. There is limited research on the biomedical application of SnO<sub>2</sub>-based nanostructures. This study aimed to investigate the role of Zn doping in relation to the anticancer potential of SnO<sub>2</sub> NPs and to enhance the anticancer potential of SnO<sub>2</sub> NPs through Z doping. Pure SnO<sub>2</sub> and Zn-doped SnO<sub>2</sub> NPs (1% and 5%) were prepared using a modified sol–gel route. XRD, TEM, SEM, EDX, UV-Vis, FTIR, and PL techniques were used to characterize the physicochemical properties of produced NPs. XRD analysis revealed that the crystalline size and phase composition of pure SnO<sub>2</sub> increased after the addition of Zn. The spherical shape and homogenous distribution of these NPs were confirmed using TEM and SEM techniques. EDX analysis confirmed the Sn, Zn, and O elements in Zn-SnO<sub>2</sub> NPs without impurities. Zn doping decreased the band gap energy of SnO<sub>2</sub> NPs. The PL study indicated a reduction in the recombination rate of charges (electrons/holes) in SnO<sub>2</sub> NPs after Zn doping. In vitro studies showed that the anticancer efficacy of SnO<sub>2</sub> NPs increased with increasing levels of Zn doping in breast cancer MCF-7 cells. Moreover, pure and Zn-doped SnO<sub>2</sub> NPs showed good cytocompatibility in HUVECs. This study emphasizes the need for additional investigation into the anticancer properties of Zn-SnO2 nanoparticles in various cancer cell lines and appropriate animal models. |
| first_indexed | 2024-03-09T17:02:55Z |
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| language | English |
| last_indexed | 2024-03-09T17:02:55Z |
| publishDate | 2023-11-01 |
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| series | Applied Sciences |
| spelling | doaj.art-cd3de4ea657f4e47a4bb297e4c7c6cd52023-11-24T14:27:54ZengMDPI AGApplied Sciences2076-34172023-11-0113221245610.3390/app132212456Zn Doping Improves the Anticancer Efficacy of SnO<sub>2</sub> NanoparticlesSitah Alanazi0ZabnAllah M. Alaizeri1Rashid Lateef2Nawal Madkhali3Abdullah Alharbi4Maqusood Ahamed5Department of Physics, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11642, Saudi ArabiaDepartment of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Biochemistry, School of Life and Basic Sciences, Jaipur National University, Jaipur 302017, Rajasthan, IndiaDepartment of Physics, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11642, Saudi ArabiaMicroelectronics and Semiconductors Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi ArabiaKing Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi ArabiaTin dioxide (SnO<sub>2</sub>) nanoparticles (NPs) can be applied in several ways due to their low cost, high surface-to-volume ratio, facile synthesis, and chemical stability. There is limited research on the biomedical application of SnO<sub>2</sub>-based nanostructures. This study aimed to investigate the role of Zn doping in relation to the anticancer potential of SnO<sub>2</sub> NPs and to enhance the anticancer potential of SnO<sub>2</sub> NPs through Z doping. Pure SnO<sub>2</sub> and Zn-doped SnO<sub>2</sub> NPs (1% and 5%) were prepared using a modified sol–gel route. XRD, TEM, SEM, EDX, UV-Vis, FTIR, and PL techniques were used to characterize the physicochemical properties of produced NPs. XRD analysis revealed that the crystalline size and phase composition of pure SnO<sub>2</sub> increased after the addition of Zn. The spherical shape and homogenous distribution of these NPs were confirmed using TEM and SEM techniques. EDX analysis confirmed the Sn, Zn, and O elements in Zn-SnO<sub>2</sub> NPs without impurities. Zn doping decreased the band gap energy of SnO<sub>2</sub> NPs. The PL study indicated a reduction in the recombination rate of charges (electrons/holes) in SnO<sub>2</sub> NPs after Zn doping. In vitro studies showed that the anticancer efficacy of SnO<sub>2</sub> NPs increased with increasing levels of Zn doping in breast cancer MCF-7 cells. Moreover, pure and Zn-doped SnO<sub>2</sub> NPs showed good cytocompatibility in HUVECs. This study emphasizes the need for additional investigation into the anticancer properties of Zn-SnO2 nanoparticles in various cancer cell lines and appropriate animal models.https://www.mdpi.com/2076-3417/13/22/12456SnO<sub>2</sub> nanoparticlesZn dopingmodified sol–gel processcharacterization anticancer activitybiocompatibility |
| spellingShingle | Sitah Alanazi ZabnAllah M. Alaizeri Rashid Lateef Nawal Madkhali Abdullah Alharbi Maqusood Ahamed Zn Doping Improves the Anticancer Efficacy of SnO<sub>2</sub> Nanoparticles Applied Sciences SnO<sub>2</sub> nanoparticles Zn doping modified sol–gel process characterization anticancer activity biocompatibility |
| title | Zn Doping Improves the Anticancer Efficacy of SnO<sub>2</sub> Nanoparticles |
| title_full | Zn Doping Improves the Anticancer Efficacy of SnO<sub>2</sub> Nanoparticles |
| title_fullStr | Zn Doping Improves the Anticancer Efficacy of SnO<sub>2</sub> Nanoparticles |
| title_full_unstemmed | Zn Doping Improves the Anticancer Efficacy of SnO<sub>2</sub> Nanoparticles |
| title_short | Zn Doping Improves the Anticancer Efficacy of SnO<sub>2</sub> Nanoparticles |
| title_sort | zn doping improves the anticancer efficacy of sno sub 2 sub nanoparticles |
| topic | SnO<sub>2</sub> nanoparticles Zn doping modified sol–gel process characterization anticancer activity biocompatibility |
| url | https://www.mdpi.com/2076-3417/13/22/12456 |
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