Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review.
INTRODUCTION: Acromegaly is a quite rare chronic disease caused by the increased secretion of growth hormone (GH) and subsequently insulin - like growth factor 1. Although cardiovascular diseases remains the most common cause of mortality among acromegalic patients, increased prevalence of malignant...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3925168?pdf=render |
| _version_ | 1818534166932750336 |
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| author | Kosma Wolinski Agata Czarnywojtek Marek Ruchala |
| author_facet | Kosma Wolinski Agata Czarnywojtek Marek Ruchala |
| author_sort | Kosma Wolinski |
| collection | DOAJ |
| description | INTRODUCTION: Acromegaly is a quite rare chronic disease caused by the increased secretion of growth hormone (GH) and subsequently insulin - like growth factor 1. Although cardiovascular diseases remains the most common cause of mortality among acromegalic patients, increased prevalence of malignant and benign neoplasms remains a matter of debate. The aim of this study is to evaluate the risk of thyroid nodular disease (TND) and thyroid cancer in patients with acromegaly. MATERIALS AND METHODS: PubMed, Cochrane Library, Scopus, Cinahl, Academic Search Complete, Web of Knowledge, PubMed Central, PubMed Central Canada and Clinical Key databases were searched to identify studies containing. Random-effects model was used to calculate pooled odds ratios and risk ratios of TND in acromegaly. Studies which not included control groups were systematically reviewed. RESULTS: TND was more frequent in acromegaly than in control groups (OR = 6.9, RR = 2.1). The pooled prevalence of TND was 59.2%. Also thyroid cancer (TC) proved to be more common in acromegalic patients (OR = 7.5, RR = 7.2), prevalence was 4.3%. The pooled rate of malignancy (calculated per patient) was equal to 8.7%. CONCLUSIONS: This study confirms that both TND and TC occur significantly more often in acromegalic patients than in general population. These results indicate that periodic thyroid ultrasound examination and careful evaluation of eventual lesions should be an important part of follow-up of patients with acromegaly. |
| first_indexed | 2024-12-11T18:08:11Z |
| format | Article |
| id | doaj.art-cd3e56cef4184bc18c7d649146f02309 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T18:08:11Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cd3e56cef4184bc18c7d649146f023092022-12-22T00:55:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8878710.1371/journal.pone.0088787Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review.Kosma WolinskiAgata CzarnywojtekMarek RuchalaINTRODUCTION: Acromegaly is a quite rare chronic disease caused by the increased secretion of growth hormone (GH) and subsequently insulin - like growth factor 1. Although cardiovascular diseases remains the most common cause of mortality among acromegalic patients, increased prevalence of malignant and benign neoplasms remains a matter of debate. The aim of this study is to evaluate the risk of thyroid nodular disease (TND) and thyroid cancer in patients with acromegaly. MATERIALS AND METHODS: PubMed, Cochrane Library, Scopus, Cinahl, Academic Search Complete, Web of Knowledge, PubMed Central, PubMed Central Canada and Clinical Key databases were searched to identify studies containing. Random-effects model was used to calculate pooled odds ratios and risk ratios of TND in acromegaly. Studies which not included control groups were systematically reviewed. RESULTS: TND was more frequent in acromegaly than in control groups (OR = 6.9, RR = 2.1). The pooled prevalence of TND was 59.2%. Also thyroid cancer (TC) proved to be more common in acromegalic patients (OR = 7.5, RR = 7.2), prevalence was 4.3%. The pooled rate of malignancy (calculated per patient) was equal to 8.7%. CONCLUSIONS: This study confirms that both TND and TC occur significantly more often in acromegalic patients than in general population. These results indicate that periodic thyroid ultrasound examination and careful evaluation of eventual lesions should be an important part of follow-up of patients with acromegaly.http://europepmc.org/articles/PMC3925168?pdf=render |
| spellingShingle | Kosma Wolinski Agata Czarnywojtek Marek Ruchala Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review. PLoS ONE |
| title | Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review. |
| title_full | Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review. |
| title_fullStr | Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review. |
| title_full_unstemmed | Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review. |
| title_short | Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly--meta-analysis and systematic review. |
| title_sort | risk of thyroid nodular disease and thyroid cancer in patients with acromegaly meta analysis and systematic review |
| url | http://europepmc.org/articles/PMC3925168?pdf=render |
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