Levels of marker lysosomal hydrolases in men of different age with ischemic heart disease through levels of sex steroids
Objective: To evaluate the serum concentrations of the three markers of lysosomal hydrolases (cathepsin D, acid phosphatase (AP) and acid DNAse (aDNAase) in men with coronary heart disease (CHD), depending on the levels of testosterone (T), estradiol (E2) and age, examine their association with anth...
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2015-09-01
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Series: | Атеросклероз |
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Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/764/702 |
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author | O. V. Tsygankova Z. G. Bondareva Yu. I. Ragino K. Yu. Nikolaev D. Yu. Platonov V. N. Maksimov M. G. Pustovetova |
author_facet | O. V. Tsygankova Z. G. Bondareva Yu. I. Ragino K. Yu. Nikolaev D. Yu. Platonov V. N. Maksimov M. G. Pustovetova |
author_sort | O. V. Tsygankova |
collection | DOAJ |
description | Objective: To evaluate the serum concentrations of the three markers of lysosomal hydrolases (cathepsin D, acid phosphatase (AP) and acid DNAse (aDNAase) in men with coronary heart disease (CHD), depending on the levels of testosterone (T), estradiol (E2) and age, examine their association with anthropometric, insulin-glucose parameters of lipid and non-lipid biomarkers of atherosclerosis. The study included 161 women aged 35–65 years, myocardial infarction (MI) is not less than 30 days before the survey. The median age was 53.1 years (25 % 75 % percentage: 40.1 and 59.4 years). The patients were divided into age groups: 35–55 years and 56–65 years (first and second groups, respectively), as well as in groups by levels of sex hormones: T> and ≤ 12 nmol / l and ≥ E2 and <0.194 nmol / l at twofold determination. The results of a comparative analysis and correlation in males 35-55 years of normal T and E2 levels were associated with higher serum concentrations of lysosomal enzymes than those with androdefitsitom and giperestrogeniey and at an older age, on the contrary, androdefitsit and hyperestrogenia lysosomal enzymes accompanied labilization of lysosomal enzymes. In men, CHD patients first age group according to the multivariate analysis three studied lysosomal enzyme inversely dependent on E2 (p < 0.001) and a number of pro-atherogenic parameters including total cholesterol (TC), low density lipoprotein (LDL) cholesterol, triglycerides (TG), hip circumference (ON), body mass index (BMI), interleukin (IL) -1β (p < 0.001–0.01), and in 56–65 years a direct impact on the levels of sex steroids lysosomal hydrolases missing, cathepsin D and EC is directly determined by the lipid, non-lipid markers of atherogenesis (TG, high-sensitivity C-reactive protein (hsCRP), malondialdehyde (MDA-30), waist circumference (WC), the index of HOMA-R, p < 0.001–0.05) and back high-density lipoprotein (HDL) cholesterol (p < 0.001). Acid DNase in both age groups dependent on the parameters involved in the insulin-glucose homeostasis (BMI, ON, TG, index HOMA-R, p < 0.001–0.05), which may reflect a key role in endonuclease accelerated catabolism activatable for various violations of carbohydrate metabolism, up to programmed cell death. Such dynamics of the three markers of lysosomal enzymes demonstrates the different contributions to the development of lysosomal cytotoxicity of CHD in men in the age groups 35–55 and 56–65 years. |
first_indexed | 2024-04-11T02:05:34Z |
format | Article |
id | doaj.art-cd3ed468e3ff4d4ca32ac0037fc70805 |
institution | Directory Open Access Journal |
issn | 2078-256X |
language | Russian |
last_indexed | 2024-04-11T02:05:34Z |
publishDate | 2015-09-01 |
publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
record_format | Article |
series | Атеросклероз |
spelling | doaj.art-cd3ed468e3ff4d4ca32ac0037fc708052023-01-03T03:18:56ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2015-09-011134250Levels of marker lysosomal hydrolases in men of different age with ischemic heart disease through levels of sex steroidsO. V. Tsygankova0Z. G. Bondareva1Yu. I. Ragino2K. Yu. Nikolaev3D. Yu. Platonov4V. N. Maksimov5M. G. Pustovetova6Novosibirsk State Medical University Russian FederationNovosibirsk State Medical University Russian FederationFSBSI «Institute of Internal and Preventive Medicine» Russian FederationFSBSI «Institute of Internal and Preventive Medicine» Russian FederationTver State Medical Academy Russian FederationFSBSI «Institute of Internal and Preventive Medicine» Russian FederationNovosibirsk State Medical University Russian FederationObjective: To evaluate the serum concentrations of the three markers of lysosomal hydrolases (cathepsin D, acid phosphatase (AP) and acid DNAse (aDNAase) in men with coronary heart disease (CHD), depending on the levels of testosterone (T), estradiol (E2) and age, examine their association with anthropometric, insulin-glucose parameters of lipid and non-lipid biomarkers of atherosclerosis. The study included 161 women aged 35–65 years, myocardial infarction (MI) is not less than 30 days before the survey. The median age was 53.1 years (25 % 75 % percentage: 40.1 and 59.4 years). The patients were divided into age groups: 35–55 years and 56–65 years (first and second groups, respectively), as well as in groups by levels of sex hormones: T> and ≤ 12 nmol / l and ≥ E2 and <0.194 nmol / l at twofold determination. The results of a comparative analysis and correlation in males 35-55 years of normal T and E2 levels were associated with higher serum concentrations of lysosomal enzymes than those with androdefitsitom and giperestrogeniey and at an older age, on the contrary, androdefitsit and hyperestrogenia lysosomal enzymes accompanied labilization of lysosomal enzymes. In men, CHD patients first age group according to the multivariate analysis three studied lysosomal enzyme inversely dependent on E2 (p < 0.001) and a number of pro-atherogenic parameters including total cholesterol (TC), low density lipoprotein (LDL) cholesterol, triglycerides (TG), hip circumference (ON), body mass index (BMI), interleukin (IL) -1β (p < 0.001–0.01), and in 56–65 years a direct impact on the levels of sex steroids lysosomal hydrolases missing, cathepsin D and EC is directly determined by the lipid, non-lipid markers of atherogenesis (TG, high-sensitivity C-reactive protein (hsCRP), malondialdehyde (MDA-30), waist circumference (WC), the index of HOMA-R, p < 0.001–0.05) and back high-density lipoprotein (HDL) cholesterol (p < 0.001). Acid DNase in both age groups dependent on the parameters involved in the insulin-glucose homeostasis (BMI, ON, TG, index HOMA-R, p < 0.001–0.05), which may reflect a key role in endonuclease accelerated catabolism activatable for various violations of carbohydrate metabolism, up to programmed cell death. Such dynamics of the three markers of lysosomal enzymes demonstrates the different contributions to the development of lysosomal cytotoxicity of CHD in men in the age groups 35–55 and 56–65 years.https://ateroskleroz.elpub.ru/jour/article/view/764/702estradioltestosteronewomencoronary heart diseaselysosomal enzymes |
spellingShingle | O. V. Tsygankova Z. G. Bondareva Yu. I. Ragino K. Yu. Nikolaev D. Yu. Platonov V. N. Maksimov M. G. Pustovetova Levels of marker lysosomal hydrolases in men of different age with ischemic heart disease through levels of sex steroids Атеросклероз estradiol testosterone women coronary heart disease lysosomal enzymes |
title | Levels of marker lysosomal hydrolases in men of different age with ischemic heart disease through levels of sex steroids |
title_full | Levels of marker lysosomal hydrolases in men of different age with ischemic heart disease through levels of sex steroids |
title_fullStr | Levels of marker lysosomal hydrolases in men of different age with ischemic heart disease through levels of sex steroids |
title_full_unstemmed | Levels of marker lysosomal hydrolases in men of different age with ischemic heart disease through levels of sex steroids |
title_short | Levels of marker lysosomal hydrolases in men of different age with ischemic heart disease through levels of sex steroids |
title_sort | levels of marker lysosomal hydrolases in men of different age with ischemic heart disease through levels of sex steroids |
topic | estradiol testosterone women coronary heart disease lysosomal enzymes |
url | https://ateroskleroz.elpub.ru/jour/article/view/764/702 |
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