Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside
This review summarizes the main achievements in basic and clinical research of atherosclerosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of how desialylation increases the atherogenic properties of low density lipoprotein...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/6/600 |
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| author | Alexandre Mezentsev Evgeny Bezsonov Dmitry Kashirskikh Mirza S. Baig Ali H. Eid Alexander Orekhov |
| author_facet | Alexandre Mezentsev Evgeny Bezsonov Dmitry Kashirskikh Mirza S. Baig Ali H. Eid Alexander Orekhov |
| author_sort | Alexandre Mezentsev |
| collection | DOAJ |
| description | This review summarizes the main achievements in basic and clinical research of atherosclerosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of how desialylation increases the atherogenic properties of low density lipoproteins and decreases the anti-atherogenic properties of high density lipoproteins. The separate sections of this paper are devoted to immunogenicity of lipoproteins, the enzymes contributing to their desialylation and animal models of atherosclerosis. In addition, we evaluate the available experimental and diagnostic protocols that can be used to develop new therapeutic approaches for atherosclerosis. |
| first_indexed | 2024-03-10T11:03:51Z |
| format | Article |
| id | doaj.art-cd3ef90d036f42c799561dd1118d9e24 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T11:03:51Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-cd3ef90d036f42c799561dd1118d9e242023-11-21T21:19:27ZengMDPI AGBiomedicines2227-90592021-05-019660010.3390/biomedicines9060600Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to BedsideAlexandre Mezentsev0Evgeny Bezsonov1Dmitry Kashirskikh2Mirza S. Baig3Ali H. Eid4Alexander Orekhov5The Institute of General Genetics, Moscow 117809, RussiaThe Institute of General Pathology and Pathophysiology, Moscow 125315, RussiaThe Institute of General Pathology and Pathophysiology, Moscow 125315, RussiaDepartment of Biosciences and Biomedical Engineering (BSBE), Indian Institute of Technology Indore (IITI), Simrol, Indore 453552, IndiaDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, P.O. Box 2713, Doha 2713, QatarThe Institute of General Pathology and Pathophysiology, Moscow 125315, RussiaThis review summarizes the main achievements in basic and clinical research of atherosclerosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of how desialylation increases the atherogenic properties of low density lipoproteins and decreases the anti-atherogenic properties of high density lipoproteins. The separate sections of this paper are devoted to immunogenicity of lipoproteins, the enzymes contributing to their desialylation and animal models of atherosclerosis. In addition, we evaluate the available experimental and diagnostic protocols that can be used to develop new therapeutic approaches for atherosclerosis.https://www.mdpi.com/2227-9059/9/6/600atherogenesisdesialylationLDLHDLapolipoproteinssialidase |
| spellingShingle | Alexandre Mezentsev Evgeny Bezsonov Dmitry Kashirskikh Mirza S. Baig Ali H. Eid Alexander Orekhov Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside Biomedicines atherogenesis desialylation LDL HDL apolipoproteins sialidase |
| title | Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside |
| title_full | Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside |
| title_fullStr | Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside |
| title_full_unstemmed | Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside |
| title_short | Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside |
| title_sort | proatherogenic sialidases and desialylated lipoproteins 35 years of research and current state from bench to bedside |
| topic | atherogenesis desialylation LDL HDL apolipoproteins sialidase |
| url | https://www.mdpi.com/2227-9059/9/6/600 |
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