Continuous-Flow Synthesis of Nitro-<i>o</i>-xylenes: Process Optimization, Impurity Study and Extension to Analogues

Continuous-Flow Synthesis of Nitro-<i>o</i>-xylenes: Process Optimization, Impurity Study and Extension to Analogues

An efficient continuous-flow nitration process of <i>o</i>-xylene at pilot scale was demonstrated. The effects of parameters such as temperature, ratio of H<sub>2</sub>SO<sub>4</sub> to HNO<sub>3</sub>, H<sub>2</sub>SO<sub>4</sub&g...

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Bibliographic Details
Main Authors: Qiao Song, Xiangui Lei, Sheng Yang, Sheng Wang, Jianhui Wang, Jiujun Chen, Yong Xiang, Qingwu Huang, Zhouyu Wang
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
continuous-flow
nitration
<i>o</i>-xylene
process optimization
impurity study
Online Access:https://www.mdpi.com/1420-3049/27/16/5139

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