CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome
Viruses completely depend on the host translational machinery, but their genomes are often enriched in rare codons and therefore should be translated with poor efficiency. Here, Jungfleisch et al. apply Ribo-Seq and RNASeq to provide a global view on the translational changes occurring during Chikun...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31835-x |
| _version_ | 1811320846904459264 |
|---|---|
| author | Jennifer Jungfleisch René Böttcher Marc Talló-Parra Gemma Pérez-Vilaró Andres Merits Eva Maria Novoa Juana Díez |
| author_facet | Jennifer Jungfleisch René Böttcher Marc Talló-Parra Gemma Pérez-Vilaró Andres Merits Eva Maria Novoa Juana Díez |
| author_sort | Jennifer Jungfleisch |
| collection | DOAJ |
| description | Viruses completely depend on the host translational machinery, but their genomes are often enriched in rare codons and therefore should be translated with poor efficiency. Here, Jungfleisch et al. apply Ribo-Seq and RNASeq to provide a global view on the translational changes occurring during Chikungunya virus (CHIKV) infection. CHIKV infection induces a codon-specific reprogramming of the host translation machinery to favor the translation of viral RNA genomes over host mRNAs via tRNA modification. |
| first_indexed | 2024-04-13T13:07:49Z |
| format | Article |
| id | doaj.art-cd415b25962d44179dcc92cd3f328cfa |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T13:07:49Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cd415b25962d44179dcc92cd3f328cfa2022-12-22T02:45:44ZengNature PortfolioNature Communications2041-17232022-08-0113111210.1038/s41467-022-31835-xCHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptomeJennifer Jungfleisch0René Böttcher1Marc Talló-Parra2Gemma Pérez-Vilaró3Andres Merits4Eva Maria Novoa5Juana Díez6Molecular Virology group, Department of Medicine and Life Sciences, Universitat Pompeu FabraMolecular Virology group, Department of Medicine and Life Sciences, Universitat Pompeu FabraMolecular Virology group, Department of Medicine and Life Sciences, Universitat Pompeu FabraMolecular Virology group, Department of Medicine and Life Sciences, Universitat Pompeu FabraInstitute of Technology, University of TartuCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and TechnologyMolecular Virology group, Department of Medicine and Life Sciences, Universitat Pompeu FabraViruses completely depend on the host translational machinery, but their genomes are often enriched in rare codons and therefore should be translated with poor efficiency. Here, Jungfleisch et al. apply Ribo-Seq and RNASeq to provide a global view on the translational changes occurring during Chikungunya virus (CHIKV) infection. CHIKV infection induces a codon-specific reprogramming of the host translation machinery to favor the translation of viral RNA genomes over host mRNAs via tRNA modification.https://doi.org/10.1038/s41467-022-31835-x |
| spellingShingle | Jennifer Jungfleisch René Böttcher Marc Talló-Parra Gemma Pérez-Vilaró Andres Merits Eva Maria Novoa Juana Díez CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome Nature Communications |
| title | CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome |
| title_full | CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome |
| title_fullStr | CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome |
| title_full_unstemmed | CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome |
| title_short | CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome |
| title_sort | chikv infection reprograms codon optimality to favor viral rna translation by altering the trna epitranscriptome |
| url | https://doi.org/10.1038/s41467-022-31835-x |
| work_keys_str_mv | AT jenniferjungfleisch chikvinfectionreprogramscodonoptimalitytofavorviralrnatranslationbyalteringthetrnaepitranscriptome AT renebottcher chikvinfectionreprogramscodonoptimalitytofavorviralrnatranslationbyalteringthetrnaepitranscriptome AT marctalloparra chikvinfectionreprogramscodonoptimalitytofavorviralrnatranslationbyalteringthetrnaepitranscriptome AT gemmaperezvilaro chikvinfectionreprogramscodonoptimalitytofavorviralrnatranslationbyalteringthetrnaepitranscriptome AT andresmerits chikvinfectionreprogramscodonoptimalitytofavorviralrnatranslationbyalteringthetrnaepitranscriptome AT evamarianovoa chikvinfectionreprogramscodonoptimalitytofavorviralrnatranslationbyalteringthetrnaepitranscriptome AT juanadiez chikvinfectionreprogramscodonoptimalitytofavorviralrnatranslationbyalteringthetrnaepitranscriptome |