Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

The basement membrane is located at tissue interfaces, but how it mediates distinct inter-tissue interactions is unclear. Here, the authors systematically define the spatial heterogeneity of skin basement membrane composition and show its functional importance in inter-tissue interactions.

Bibliographic Details
Main Authors: Ko Tsutsui, Hiroki Machida, Asako Nakagawa, Kyungmin Ahn, Ritsuko Morita, Kiyotoshi Sekiguchi, Jeffrey H. Miner, Hironobu Fujiwara
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22881-y
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author Ko Tsutsui
Hiroki Machida
Asako Nakagawa
Kyungmin Ahn
Ritsuko Morita
Kiyotoshi Sekiguchi
Jeffrey H. Miner
Hironobu Fujiwara
author_facet Ko Tsutsui
Hiroki Machida
Asako Nakagawa
Kyungmin Ahn
Ritsuko Morita
Kiyotoshi Sekiguchi
Jeffrey H. Miner
Hironobu Fujiwara
author_sort Ko Tsutsui
collection DOAJ
description The basement membrane is located at tissue interfaces, but how it mediates distinct inter-tissue interactions is unclear. Here, the authors systematically define the spatial heterogeneity of skin basement membrane composition and show its functional importance in inter-tissue interactions.
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spelling doaj.art-cd420d1bdef94731b034f9f7e801a5662022-12-21T23:38:57ZengNature PortfolioNature Communications2041-17232021-05-0112111810.1038/s41467-021-22881-yMapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactionsKo Tsutsui0Hiroki Machida1Asako Nakagawa2Kyungmin Ahn3Ritsuko Morita4Kiyotoshi Sekiguchi5Jeffrey H. Miner6Hironobu Fujiwara7Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)Laboratory of Matrixome Research and Application, Institute for Protein Research, Osaka UniversityDivision of Nephrology, Department of Medicine, Washington University School of MedicineLaboratory for Tissue Microenvironment, RIKEN Center for Biosystems Dynamics Research (BDR)The basement membrane is located at tissue interfaces, but how it mediates distinct inter-tissue interactions is unclear. Here, the authors systematically define the spatial heterogeneity of skin basement membrane composition and show its functional importance in inter-tissue interactions.https://doi.org/10.1038/s41467-021-22881-y
spellingShingle Ko Tsutsui
Hiroki Machida
Asako Nakagawa
Kyungmin Ahn
Ritsuko Morita
Kiyotoshi Sekiguchi
Jeffrey H. Miner
Hironobu Fujiwara
Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions
Nature Communications
title Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions
title_full Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions
title_fullStr Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions
title_full_unstemmed Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions
title_short Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions
title_sort mapping the molecular and structural specialization of the skin basement membrane for inter tissue interactions
url https://doi.org/10.1038/s41467-021-22881-y
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