Magnetic Resonance Spectroscopy Findings and Cognitive Function in Patients with Parkinson’s disease
Background and Purpose: Cognitive impairment (CI) is one of the most notable disabilities of Parkinson’s disease that is associated with lower quality of life. Early detection of CI is therefore very important for these patients. The purpose of this study was to examine the relationship between cogn...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Shahid Beheshti University of Medical Sciences
2017-04-01
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| Series: | International Clinical Neuroscience Journal |
| Online Access: | http://journals.sbmu.ac.ir/Neuroscience/article/download/16997/3 |
| _version_ | 1811224811991465984 |
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| author | Farzad Ashrafi Abdolnasser Rostami Mehran Arab Ahmadi Behdad Behnam |
| author_facet | Farzad Ashrafi Abdolnasser Rostami Mehran Arab Ahmadi Behdad Behnam |
| author_sort | Farzad Ashrafi |
| collection | DOAJ |
| description | Background and Purpose: Cognitive impairment (CI) is one of the most notable disabilities of Parkinson’s disease that is associated with lower quality of life. Early detection of CI is therefore very important for these patients. The purpose of this study was to examine the relationship between cognitive function and the metabolic data from magnetic resonance spectroscopy (MRS) of the patient suffering with Parkinson’s disease. Methods: Totally, 45 patients with Parkinson’s disease were used in this study. Subjects were divided into three groups based on scales for outcome from Parkinson cognition (SCOPACOG) test. Patients were classified as non-cognitive impairment (NCI; n=15), mild cognitive impairment (MCI; n=15) and dementia (PDD; n=15). All subjects underwent MRI and 1 H-MRS techniques and metabolic changes such as NAA/Cr and NAA/Cho ratios, which were measured in the left hippocampal area of the brain. Results: The mean and standard deviation of the NAA/Cr ratio in the three cognitive groups (NCI, MCI, PDD) were (2.51±0.037), (2.50±0.033) and (2.47±0.025), respectively. ANOVA test showed a significant difference in the three groups. Furthermore, the Scheffé test showed a significant difference between patients in the MCI and PDD groups (p=0.01). There was no significant difference between the non-cognitive impairment and mild cognitive impairment groups (p=0.54). No significant difference was found in NAA/Cho ratio (p=091). Conclusion: A decreasing NAA/Cr ratio has influence on cognitive function and the development of severe cognitive dysfunction in Parkinson suffering patients. Furthermore, 1 H-MRS determinant can be useful to evaluate cognition in Parkinson patients. |
| first_indexed | 2024-04-12T08:55:23Z |
| format | Article |
| id | doaj.art-cd4239dae3ef47e4a25c9707001a7cd8 |
| institution | Directory Open Access Journal |
| issn | 2383-1871 2383-2096 |
| language | English |
| last_indexed | 2024-04-12T08:55:23Z |
| publishDate | 2017-04-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | International Clinical Neuroscience Journal |
| spelling | doaj.art-cd4239dae3ef47e4a25c9707001a7cd82022-12-22T03:39:26ZengShahid Beheshti University of Medical SciencesInternational Clinical Neuroscience Journal2383-18712383-20962017-04-0142465010.22037/icnj.v4i2.16997icnj-3121Magnetic Resonance Spectroscopy Findings and Cognitive Function in Patients with Parkinson’s diseaseFarzad Ashrafi0Abdolnasser Rostami1Mehran Arab Ahmadi2Behdad Behnam3Functional Neurosurgery Research Center, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Radiology School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranFunctional Neurosurgery Research Center, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Functional Neurosurgery Research Center, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Background and Purpose: Cognitive impairment (CI) is one of the most notable disabilities of Parkinson’s disease that is associated with lower quality of life. Early detection of CI is therefore very important for these patients. The purpose of this study was to examine the relationship between cognitive function and the metabolic data from magnetic resonance spectroscopy (MRS) of the patient suffering with Parkinson’s disease. Methods: Totally, 45 patients with Parkinson’s disease were used in this study. Subjects were divided into three groups based on scales for outcome from Parkinson cognition (SCOPACOG) test. Patients were classified as non-cognitive impairment (NCI; n=15), mild cognitive impairment (MCI; n=15) and dementia (PDD; n=15). All subjects underwent MRI and 1 H-MRS techniques and metabolic changes such as NAA/Cr and NAA/Cho ratios, which were measured in the left hippocampal area of the brain. Results: The mean and standard deviation of the NAA/Cr ratio in the three cognitive groups (NCI, MCI, PDD) were (2.51±0.037), (2.50±0.033) and (2.47±0.025), respectively. ANOVA test showed a significant difference in the three groups. Furthermore, the Scheffé test showed a significant difference between patients in the MCI and PDD groups (p=0.01). There was no significant difference between the non-cognitive impairment and mild cognitive impairment groups (p=0.54). No significant difference was found in NAA/Cho ratio (p=091). Conclusion: A decreasing NAA/Cr ratio has influence on cognitive function and the development of severe cognitive dysfunction in Parkinson suffering patients. Furthermore, 1 H-MRS determinant can be useful to evaluate cognition in Parkinson patients.http://journals.sbmu.ac.ir/Neuroscience/article/download/16997/3 |
| spellingShingle | Farzad Ashrafi Abdolnasser Rostami Mehran Arab Ahmadi Behdad Behnam Magnetic Resonance Spectroscopy Findings and Cognitive Function in Patients with Parkinson’s disease International Clinical Neuroscience Journal |
| title | Magnetic Resonance Spectroscopy Findings and Cognitive Function in Patients with Parkinson’s disease |
| title_full | Magnetic Resonance Spectroscopy Findings and Cognitive Function in Patients with Parkinson’s disease |
| title_fullStr | Magnetic Resonance Spectroscopy Findings and Cognitive Function in Patients with Parkinson’s disease |
| title_full_unstemmed | Magnetic Resonance Spectroscopy Findings and Cognitive Function in Patients with Parkinson’s disease |
| title_short | Magnetic Resonance Spectroscopy Findings and Cognitive Function in Patients with Parkinson’s disease |
| title_sort | magnetic resonance spectroscopy findings and cognitive function in patients with parkinson s disease |
| url | http://journals.sbmu.ac.ir/Neuroscience/article/download/16997/3 |
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