Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics

Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics

ABSTRACT The bacterial SOS response is a DNA damage repair network that is strongly implicated in both survival and acquired drug resistance under antimicrobial stress. The two SOS regulators, LexA and RecA, have therefore emerged as potential targets for adjuvant therapies aimed at combating resist...

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Bibliographic Details
Main Authors: Charlie Y. Mo, Sara A. Manning, Manuela Roggiani, Matthew J. Culyba, Amanda N. Samuels, Paul D. Sniegowski, Mark Goulian, Rahul M. Kohli
Format: Article
Language:English
Published: American Society for Microbiology 2016-08-01
Series:mSphere
Subjects:
DNA damage
LexA
RecA
SOS pathway
adjuvant therapy
antibiotic resistance
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00163-16

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