Short communication: The miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by Leishmania braziliensis.
Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis, is a disease characterized by well-limited ulcerated lesions with raised borders in exposed parts of the body. miRNAs are recognized for their role in the complex and plastic interaction between host and pathogens, either as part of the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298458&type=printable |
| _version_ | 1797295171197468672 |
|---|---|
| author | Tainã Lago Thyago Marconi Cardoso Alan Rocha Edgar M Carvalho Léa Cristina Castellucci |
| author_facet | Tainã Lago Thyago Marconi Cardoso Alan Rocha Edgar M Carvalho Léa Cristina Castellucci |
| author_sort | Tainã Lago |
| collection | DOAJ |
| description | Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis, is a disease characterized by well-limited ulcerated lesions with raised borders in exposed parts of the body. miRNAs are recognized for their role in the complex and plastic interaction between host and pathogens, either as part of the host's strategy to neutralize infection or as a molecular mechanism employed by the pathogen to modulate host inflammatory pathways to remain undetected. The mir155 targets a broad range of inflammatory mediators, following toll-like receptors (TLRs) signaling. In this work, we evaluated the effects of the expression of miR155a-5p in human macrophages infected with L. braziliensis. Our results show that miR155a-5p is inversely correlated with early apoptosis and conversely, seems to influence an increment in the oxidative burst in these cells. Altogether, we spotted a functional role of the miR155a-5p in CL pathogenesis, raising the hypothesis that an increased miR-155 expression by TLR ligands influences cellular mechanisms settled to promote both killing and control of parasite density after infection. |
| first_indexed | 2024-03-07T21:42:54Z |
| format | Article |
| id | doaj.art-cd43c26ab97f4105830b3ae1bd5b56db |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-07T21:42:54Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cd43c26ab97f4105830b3ae1bd5b56db2024-02-26T05:31:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01192e029845810.1371/journal.pone.0298458Short communication: The miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by Leishmania braziliensis.Tainã LagoThyago Marconi CardosoAlan RochaEdgar M CarvalhoLéa Cristina CastellucciCutaneous leishmaniasis (CL) caused by Leishmania braziliensis, is a disease characterized by well-limited ulcerated lesions with raised borders in exposed parts of the body. miRNAs are recognized for their role in the complex and plastic interaction between host and pathogens, either as part of the host's strategy to neutralize infection or as a molecular mechanism employed by the pathogen to modulate host inflammatory pathways to remain undetected. The mir155 targets a broad range of inflammatory mediators, following toll-like receptors (TLRs) signaling. In this work, we evaluated the effects of the expression of miR155a-5p in human macrophages infected with L. braziliensis. Our results show that miR155a-5p is inversely correlated with early apoptosis and conversely, seems to influence an increment in the oxidative burst in these cells. Altogether, we spotted a functional role of the miR155a-5p in CL pathogenesis, raising the hypothesis that an increased miR-155 expression by TLR ligands influences cellular mechanisms settled to promote both killing and control of parasite density after infection.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298458&type=printable |
| spellingShingle | Tainã Lago Thyago Marconi Cardoso Alan Rocha Edgar M Carvalho Léa Cristina Castellucci Short communication: The miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by Leishmania braziliensis. PLoS ONE |
| title | Short communication: The miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by Leishmania braziliensis. |
| title_full | Short communication: The miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by Leishmania braziliensis. |
| title_fullStr | Short communication: The miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by Leishmania braziliensis. |
| title_full_unstemmed | Short communication: The miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by Leishmania braziliensis. |
| title_short | Short communication: The miR-155a-5p is correlated with increased ROS and impaired apoptosis in macrophages infected by Leishmania braziliensis. |
| title_sort | short communication the mir 155a 5p is correlated with increased ros and impaired apoptosis in macrophages infected by leishmania braziliensis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298458&type=printable |
| work_keys_str_mv | AT tainalago shortcommunicationthemir155a5piscorrelatedwithincreasedrosandimpairedapoptosisinmacrophagesinfectedbyleishmaniabraziliensis AT thyagomarconicardoso shortcommunicationthemir155a5piscorrelatedwithincreasedrosandimpairedapoptosisinmacrophagesinfectedbyleishmaniabraziliensis AT alanrocha shortcommunicationthemir155a5piscorrelatedwithincreasedrosandimpairedapoptosisinmacrophagesinfectedbyleishmaniabraziliensis AT edgarmcarvalho shortcommunicationthemir155a5piscorrelatedwithincreasedrosandimpairedapoptosisinmacrophagesinfectedbyleishmaniabraziliensis AT leacristinacastellucci shortcommunicationthemir155a5piscorrelatedwithincreasedrosandimpairedapoptosisinmacrophagesinfectedbyleishmaniabraziliensis |