The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants

The Toxicology of Native Fucosylated Glycosaminoglycans and the Safety of Their Depolymerized Products as Anticoagulants

Fucosylated glycosaminoglycan (FG) from sea cucumber is a potent anticoagulant by inhibiting intrinsic coagulation tenase (iXase). However, high-molecular-weight FGs can activate platelets and plasma contact system, and induce hypotension in rats, which limits its application. Herein, we found that...

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Bibliographic Details
Main Authors: Lisha Lin, Sujuan Li, Na Gao, Weili Wang, Taocui Zhang, Lian Yang, Xingzhi Yang, Dan Luo, Xu Ji, Jinhua Zhao
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Marine Drugs
Subjects:
fucosylated glycosaminoglycan
anticoagulant
platelet aggregation
contact activation
hypotension
pulmonary embolism
Online Access:https://www.mdpi.com/1660-3397/19/9/487

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