Age related immune modulation of experimental autoimmune encephalomyelitis in PINK1 knockout mice

Age related immune modulation of experimental autoimmune encephalomyelitis in PINK1 knockout mice

ObjectiveRecent research has shown that Parkin, an E3 ubiquitin ligase, modulates peripheral immune cells-mediated immunity during experimental autoimmune encephalomyelitis (EAE). Because the PTEN-induced putative kinase 1 (PINK1) protein acts upstream of Parkin in a common mitochondrial quality con...

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Bibliographic Details
Main Authors: Davide Cossu, Kazumasa Yokoyama, Shigeto Sato, Sachiko Noda, Tamami Sakanishi, Leonardo Antonio Sechi, Nobutaka Hattori
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
PINK1
neuroinflammation
experimental autoimmune encephalomyelitis
Parkinson’s disease
multiple sclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1036680/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1036680/full

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