Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy
Small nucleolar RNA host gene 14 (SNHG14) is a long non-coding RNA found to be overexpressed in various types of cancers. Moreover, the expression level of SNHG14 was closely associated with multiple clinicopathological characteristics such as prognosis, tumor differentiation, TNM stage, and lymph n...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.746714/full |
| _version_ | 1819125201299832832 |
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| author | Shen Shen Shen Shen Yanfang Wang Yize Zhang Yize Zhang Zihui Dong Zihui Dong Jiyuan Xing Jiyuan Xing |
| author_facet | Shen Shen Shen Shen Yanfang Wang Yize Zhang Yize Zhang Zihui Dong Zihui Dong Jiyuan Xing Jiyuan Xing |
| author_sort | Shen Shen |
| collection | DOAJ |
| description | Small nucleolar RNA host gene 14 (SNHG14) is a long non-coding RNA found to be overexpressed in various types of cancers. Moreover, the expression level of SNHG14 was closely associated with multiple clinicopathological characteristics such as prognosis, tumor differentiation, TNM stage, and lymph node metastasis. Functionally, gain- and loss-of-function of SNHG14 revealed that overexpressed SNHG14 promoted cancer cell viability, invasion, and migration, whereas its down-regulation produced the opposite effect. Mechanistically, regulating its target gene expression by sponging distinct miRNAs might be the major mechanism underlying the oncogenic functions of SNHG14. Thus, SNHG14 might be a promising prognostic biomarker and therapeutic target for cancers. In this review, we discuss the expression profile, biological function, and molecular mechanisms of SNHG14 in cancers to provide a molecular basis for the clinical utility of SNHG14 in the future. |
| first_indexed | 2024-12-22T07:36:22Z |
| format | Article |
| id | doaj.art-cd49fb0a5a8b411280fc57446ffc82ab |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T07:36:22Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-cd49fb0a5a8b411280fc57446ffc82ab2022-12-21T18:33:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-09-01910.3389/fcell.2021.746714746714Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in MalignancyShen Shen0Shen Shen1Yanfang Wang2Yize Zhang3Yize Zhang4Zihui Dong5Zihui Dong6Jiyuan Xing7Jiyuan Xing8Precision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaPrecision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaPrecision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaPrecision Medicine Center, Gene Hospital of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaSmall nucleolar RNA host gene 14 (SNHG14) is a long non-coding RNA found to be overexpressed in various types of cancers. Moreover, the expression level of SNHG14 was closely associated with multiple clinicopathological characteristics such as prognosis, tumor differentiation, TNM stage, and lymph node metastasis. Functionally, gain- and loss-of-function of SNHG14 revealed that overexpressed SNHG14 promoted cancer cell viability, invasion, and migration, whereas its down-regulation produced the opposite effect. Mechanistically, regulating its target gene expression by sponging distinct miRNAs might be the major mechanism underlying the oncogenic functions of SNHG14. Thus, SNHG14 might be a promising prognostic biomarker and therapeutic target for cancers. In this review, we discuss the expression profile, biological function, and molecular mechanisms of SNHG14 in cancers to provide a molecular basis for the clinical utility of SNHG14 in the future.https://www.frontiersin.org/articles/10.3389/fcell.2021.746714/fullmalignancylncRNASNHG14biomarkerprognosis |
| spellingShingle | Shen Shen Shen Shen Yanfang Wang Yize Zhang Yize Zhang Zihui Dong Zihui Dong Jiyuan Xing Jiyuan Xing Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy Frontiers in Cell and Developmental Biology malignancy lncRNA SNHG14 biomarker prognosis |
| title | Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy |
| title_full | Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy |
| title_fullStr | Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy |
| title_full_unstemmed | Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy |
| title_short | Long Non-coding RNA Small Nucleolar RNA Host Gene 14, a Promising Biomarker and Therapeutic Target in Malignancy |
| title_sort | long non coding rna small nucleolar rna host gene 14 a promising biomarker and therapeutic target in malignancy |
| topic | malignancy lncRNA SNHG14 biomarker prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.746714/full |
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