Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties

Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties

Retinal pigment epithelium (RPE) acts as an outer blood−retinal barrier that limits the access of circulating xenobiotics to the eye. In addition, the RPE limits posterior elimination of intravitreally injected drugs to circulation. Thus, permeation in the RPE has a significant effect on o...

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Bibliographic Details
Main Authors:	Laura Hellinen, Lea Pirskanen, Unni Tengvall-Unadike, Arto Urtti, Mika Reinisalo
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Series:	Pharmaceutics
Subjects:	retinal pigment epithelium outer blood–retinal barrier cell line ARPE19 differentiation tight junctions microvilli drug permeation beta-blockers
Online Access:	https://www.mdpi.com/1999-4923/11/8/412

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