Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future Perspectives
Cardiovascular and related diseases (CVRDs) are among the most prevalent chronic diseases in the 21st century, with a high mortality rate. This review summarizes the various nanomedicines for diagnostic and therapeutic applications in CVRDs, including nanomedicine for angina pectoris, myocarditis, m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/4/441 |
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| author | Natasha Manners Vishnu Priya Abhishesh Kumar Mehata Manoj Rawat Syam Mohan Hafiz A. Makeen Mohammed Albratty Ali Albarrati Abdulkarim M. Meraya Madaswamy S. Muthu |
| author_facet | Natasha Manners Vishnu Priya Abhishesh Kumar Mehata Manoj Rawat Syam Mohan Hafiz A. Makeen Mohammed Albratty Ali Albarrati Abdulkarim M. Meraya Madaswamy S. Muthu |
| author_sort | Natasha Manners |
| collection | DOAJ |
| description | Cardiovascular and related diseases (CVRDs) are among the most prevalent chronic diseases in the 21st century, with a high mortality rate. This review summarizes the various nanomedicines for diagnostic and therapeutic applications in CVRDs, including nanomedicine for angina pectoris, myocarditis, myocardial infarction, pericardial disorder, thrombosis, atherosclerosis, hyperlipidemia, hypertension, pulmonary arterial hypertension and stroke. Theranostic nanomedicines can prolong systemic circulation, escape from the host defense system, and deliver theranostic agents to the targeted site for imaging and therapy at a cellular and molecular level. Presently, discrete non-invasive and non-surgical theranostic methodologies are such an advancement modality capable of targeted diagnosis and therapy and have better efficacy with fewer side effects than conventional medicine. Additionally, we have presented the recent updates on nanomedicine in clinical trials, targeted nanomedicine and its translational challenges for CVRDs. Theranostic nanomedicine acts as a bridge towards CVRDs amelioration and its management. |
| first_indexed | 2024-03-09T13:10:00Z |
| format | Article |
| id | doaj.art-cd4a70f6ac394c55a45f8f35a0fea677 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T13:10:00Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-cd4a70f6ac394c55a45f8f35a0fea6772023-11-30T21:43:03ZengMDPI AGPharmaceuticals1424-82472022-04-0115444110.3390/ph15040441Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future PerspectivesNatasha Manners0Vishnu Priya1Abhishesh Kumar Mehata2Manoj Rawat3Syam Mohan4Hafiz A. Makeen5Mohammed Albratty6Ali Albarrati7Abdulkarim M. Meraya8Madaswamy S. Muthu9Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi 221005, IndiaDepartment of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi 221005, IndiaDepartment of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi 221005, IndiaNovartis Healthcare Private Limited, Hyderabad 500078, IndiaSubstance Abuse and Toxicology Research Center, Jazan University, Jazan 45142, Saudi ArabiaPharmacy Practice Research Unit, Clinical Pharmacy Department, College of Pharmacy, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan 45142, Saudi ArabiaRehabilitation Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi ArabiaPharmacy Practice Research Unit, Clinical Pharmacy Department, College of Pharmacy, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi 221005, IndiaCardiovascular and related diseases (CVRDs) are among the most prevalent chronic diseases in the 21st century, with a high mortality rate. This review summarizes the various nanomedicines for diagnostic and therapeutic applications in CVRDs, including nanomedicine for angina pectoris, myocarditis, myocardial infarction, pericardial disorder, thrombosis, atherosclerosis, hyperlipidemia, hypertension, pulmonary arterial hypertension and stroke. Theranostic nanomedicines can prolong systemic circulation, escape from the host defense system, and deliver theranostic agents to the targeted site for imaging and therapy at a cellular and molecular level. Presently, discrete non-invasive and non-surgical theranostic methodologies are such an advancement modality capable of targeted diagnosis and therapy and have better efficacy with fewer side effects than conventional medicine. Additionally, we have presented the recent updates on nanomedicine in clinical trials, targeted nanomedicine and its translational challenges for CVRDs. Theranostic nanomedicine acts as a bridge towards CVRDs amelioration and its management.https://www.mdpi.com/1424-8247/15/4/441atherosclerosiscardiovascular diseasepersonalized therapypharmaceutical nanomedicinetargeted delivery |
| spellingShingle | Natasha Manners Vishnu Priya Abhishesh Kumar Mehata Manoj Rawat Syam Mohan Hafiz A. Makeen Mohammed Albratty Ali Albarrati Abdulkarim M. Meraya Madaswamy S. Muthu Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future Perspectives Pharmaceuticals atherosclerosis cardiovascular disease personalized therapy pharmaceutical nanomedicine targeted delivery |
| title | Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future Perspectives |
| title_full | Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future Perspectives |
| title_fullStr | Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future Perspectives |
| title_full_unstemmed | Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future Perspectives |
| title_short | Theranostic Nanomedicines for the Treatment of Cardiovascular and Related Diseases: Current Strategies and Future Perspectives |
| title_sort | theranostic nanomedicines for the treatment of cardiovascular and related diseases current strategies and future perspectives |
| topic | atherosclerosis cardiovascular disease personalized therapy pharmaceutical nanomedicine targeted delivery |
| url | https://www.mdpi.com/1424-8247/15/4/441 |
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