Abnormal cerebellar network and effective connectivity in sudden and long-term sensorineural hearing loss
Sudden sensorineural hearing loss (SSNHL) is a common otology emergency and some SSNHL will develop into a long-term hearing loss (LSNHL). However, whether SSNHL and LSNHL have similar psychiatric patterns remains unknown, as well as the neural substrates. Increasing evidence has proved that the cer...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.964349/full |
| _version_ | 1828184349272440832 |
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| author | Jin-Chao Hua Xiao-Min Xu Zhen-Gui Xu Yuan Xue Jin-Jing Xu Jing-Hua Hu Yuanqing Wu Yu-Chen Chen |
| author_facet | Jin-Chao Hua Xiao-Min Xu Zhen-Gui Xu Yuan Xue Jin-Jing Xu Jing-Hua Hu Yuanqing Wu Yu-Chen Chen |
| author_sort | Jin-Chao Hua |
| collection | DOAJ |
| description | Sudden sensorineural hearing loss (SSNHL) is a common otology emergency and some SSNHL will develop into a long-term hearing loss (LSNHL). However, whether SSNHL and LSNHL have similar psychiatric patterns remains unknown, as well as the neural substrates. Increasing evidence has proved that the cerebellar network plays a vital role in hearing, cognition processing, and emotion control. Thus, we recruited 20 right SSNHL (RSSNHL), 20 right LSNHL (RLSNHL), and 24 well-matched healthy controls to explore the cerebellar patterns among the three groups. Every participant underwent pure tone audiometry tests, neuropsychological evaluations, and MRI scanning. Independent component analysis (ICA) was carried out on the MRI data and the cerebellar network was extracted. Granger causality analysis (GCA) was conducted using the significant cerebellar region as a seed. Pearson’s correlation analysis was computed between imaging characteristics and clinical features. ICA found the effect of group on right cerebellum lobule V for the cerebellar network. Then, we found decreased outflow from right cerebellum lobule V to right middle orbitofrontal cortex, inferior frontal gyrus, anterior cingulate cortex, superior temporal gyrus, and dorsal lateral prefrontal cortex in RSSNHL group in GCA analysis. No significance was found in RLSNHL subjects. Additionally, the RSSNHL group showed increased effective connectivity from the right middle frontal gyrus (MFG) and the RLSNHL group showed increased effective connectivity from the right insula and temporal pole to the right cerebellum lobule V. Moreover, connections between right cerebellum lobule V and mean time series of the cerebellar network was negatively correlated with anxiety score in RSSNHL and negatively correlated with depression scores in RLSNHL. Effective connectivity from right MFG to right cerebellum lobule V could predict anxiety status in RSSNHL subjects. Our results may prove potential imaging biomarkers and treatment targets for hearing loss in future work. |
| first_indexed | 2024-04-12T06:47:22Z |
| format | Article |
| id | doaj.art-cd4ad89c811f4777ad8600120932aa1a |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T06:47:22Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-cd4ad89c811f4777ad8600120932aa1a2022-12-22T03:43:31ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.964349964349Abnormal cerebellar network and effective connectivity in sudden and long-term sensorineural hearing lossJin-Chao Hua0Xiao-Min Xu1Zhen-Gui Xu2Yuan Xue3Jin-Jing Xu4Jing-Hua Hu5Yuanqing Wu6Yu-Chen Chen7Department of Otolaryngology, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Otolaryngology, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, ChinaDepartment of Otolaryngology, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, ChinaDepartment of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, ChinaSudden sensorineural hearing loss (SSNHL) is a common otology emergency and some SSNHL will develop into a long-term hearing loss (LSNHL). However, whether SSNHL and LSNHL have similar psychiatric patterns remains unknown, as well as the neural substrates. Increasing evidence has proved that the cerebellar network plays a vital role in hearing, cognition processing, and emotion control. Thus, we recruited 20 right SSNHL (RSSNHL), 20 right LSNHL (RLSNHL), and 24 well-matched healthy controls to explore the cerebellar patterns among the three groups. Every participant underwent pure tone audiometry tests, neuropsychological evaluations, and MRI scanning. Independent component analysis (ICA) was carried out on the MRI data and the cerebellar network was extracted. Granger causality analysis (GCA) was conducted using the significant cerebellar region as a seed. Pearson’s correlation analysis was computed between imaging characteristics and clinical features. ICA found the effect of group on right cerebellum lobule V for the cerebellar network. Then, we found decreased outflow from right cerebellum lobule V to right middle orbitofrontal cortex, inferior frontal gyrus, anterior cingulate cortex, superior temporal gyrus, and dorsal lateral prefrontal cortex in RSSNHL group in GCA analysis. No significance was found in RLSNHL subjects. Additionally, the RSSNHL group showed increased effective connectivity from the right middle frontal gyrus (MFG) and the RLSNHL group showed increased effective connectivity from the right insula and temporal pole to the right cerebellum lobule V. Moreover, connections between right cerebellum lobule V and mean time series of the cerebellar network was negatively correlated with anxiety score in RSSNHL and negatively correlated with depression scores in RLSNHL. Effective connectivity from right MFG to right cerebellum lobule V could predict anxiety status in RSSNHL subjects. Our results may prove potential imaging biomarkers and treatment targets for hearing loss in future work.https://www.frontiersin.org/articles/10.3389/fnagi.2022.964349/fullcerebellar networksudden sensorineural hearing losslong term sensorineural hearing lossindependent component analysiseffective connectivity |
| spellingShingle | Jin-Chao Hua Xiao-Min Xu Zhen-Gui Xu Yuan Xue Jin-Jing Xu Jing-Hua Hu Yuanqing Wu Yu-Chen Chen Abnormal cerebellar network and effective connectivity in sudden and long-term sensorineural hearing loss Frontiers in Aging Neuroscience cerebellar network sudden sensorineural hearing loss long term sensorineural hearing loss independent component analysis effective connectivity |
| title | Abnormal cerebellar network and effective connectivity in sudden and long-term sensorineural hearing loss |
| title_full | Abnormal cerebellar network and effective connectivity in sudden and long-term sensorineural hearing loss |
| title_fullStr | Abnormal cerebellar network and effective connectivity in sudden and long-term sensorineural hearing loss |
| title_full_unstemmed | Abnormal cerebellar network and effective connectivity in sudden and long-term sensorineural hearing loss |
| title_short | Abnormal cerebellar network and effective connectivity in sudden and long-term sensorineural hearing loss |
| title_sort | abnormal cerebellar network and effective connectivity in sudden and long term sensorineural hearing loss |
| topic | cerebellar network sudden sensorineural hearing loss long term sensorineural hearing loss independent component analysis effective connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.964349/full |
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