T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation

T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation

The transcriptional co-activator BOB.1/OBF.1 is expressed in both B and T cells. The main characteristic of conventional BOB.1/OBF.1 deficient mice is the complete absence of germinal centers (GCs). This defect was mainly attributed to the defective B cell compartment. However, it is unknown whether...

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Bibliographic Details
Main Authors: Annika C. Betzler, Jasmin Ezić, Tsima Abou Kors, Thomas K. Hoffmann, Thomas Wirth, Cornelia Brunner
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
BOB.1/OBF.1
germinal center
T cell differentiation
follicular T helper cells
humoral immunity
transcriptional co-activator
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.889564/full

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