Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade

Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade

Background BANF1 is well known as a natural opponent of cyclic GMP-AMP synthase (cGAS) activity on genomic self-DNA. However, the roles of BANF1 in tumor immunity remain unclear. Here, we investigate the possible impact of BANF1 on antitumor immunity and response to immunotherapy.Methods The Cancer...

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Bibliographic Details
Main Authors: Fei Wang, Yang Li, Jinming Yu, Dawei Chen, Fei Wu, Meng Wu, Minglei Wang, Yiheng Huang, Minxin Chen, Weiyan Wang, Tao Zhong, Xiaozheng Chen
Format: Article
Language:English
Published: BMJ Publishing Group 2023-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/8/e007035.full

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https://jitc.bmj.com/content/11/8/e007035.full

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