Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells
Dendritic cells are antigen-presenting cells, which identify and process pathogens to subsequently activate specific T lymphocytes. To regulate the immune responses, DCs have to mature by the recognition of TLR ligands, TNFα or IFNγ. These ligands have been used as adjuvants to activate DCs in situ...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/4/1451 |
| _version_ | 1797477614460338176 |
|---|---|
| author | Gabriela Piñón-Zárate Fernanda Reyes-Riquelme Ma Beatriz Sánchez-Monroy Mónica Velasco-Torrez Mariano Martínez-Vázquez Christian Adrian Cárdenas-Monroy Beatriz Hernandez-Téllez Katia Jarquín-Yáñez Miguel Ángel Herrera-Enríquez Andrés Eliú Castell-Rodríguez |
| author_facet | Gabriela Piñón-Zárate Fernanda Reyes-Riquelme Ma Beatriz Sánchez-Monroy Mónica Velasco-Torrez Mariano Martínez-Vázquez Christian Adrian Cárdenas-Monroy Beatriz Hernandez-Téllez Katia Jarquín-Yáñez Miguel Ángel Herrera-Enríquez Andrés Eliú Castell-Rodríguez |
| author_sort | Gabriela Piñón-Zárate |
| collection | DOAJ |
| description | Dendritic cells are antigen-presenting cells, which identify and process pathogens to subsequently activate specific T lymphocytes. To regulate the immune responses, DCs have to mature by the recognition of TLR ligands, TNFα or IFNγ. These ligands have been used as adjuvants to activate DCs in situ or in vitro, with toxic effects. It has been shown that some molecules affect the immune system, e.g., Masticadienonic acid (MDA) and 3α-hydroxy masticadienoic acid (3α-OH MDA) triterpenes naturally occurring in several medicinal plants, since they activate the nitric oxide synthase in macrophages and induce T lymphocyte proliferation. The DCs maturation induced by MDA or 3a-OH MDA was determined by incubating these cells with MDA or 3α-OH MDA, and their phenotype was afterwards analyzed. The results showed that only 3α-OH MDA was able to induce DCs maturation. When mice with melanoma were inoculated with DCs/3α-OH MDA, a decreased tumor growth rate was observed along with an extended cell death area within tumors compared to mice treated with DCs incubated with MDA. In conclusion, it is proposed that 3α-OH MDA may be an immunostimulant molecule. Conversely, it is proposed that MDA may be a molecule with anti-inflammatory properties. |
| first_indexed | 2024-03-09T21:20:13Z |
| format | Article |
| id | doaj.art-cd54434f9e6b4e15af80c91ae22c7ba3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:20:13Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cd54434f9e6b4e15af80c91ae22c7ba32023-11-23T21:24:10ZengMDPI AGMolecules1420-30492022-02-01274145110.3390/molecules27041451Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic CellsGabriela Piñón-Zárate0Fernanda Reyes-Riquelme1Ma Beatriz Sánchez-Monroy2Mónica Velasco-Torrez3Mariano Martínez-Vázquez4Christian Adrian Cárdenas-Monroy5Beatriz Hernandez-Téllez6Katia Jarquín-Yáñez7Miguel Ángel Herrera-Enríquez8Andrés Eliú Castell-Rodríguez9Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoDepartamento de Ecología y Recursos Naturales, Facultad de Ciencias, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoDepartamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoFacultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, MexicoDendritic cells are antigen-presenting cells, which identify and process pathogens to subsequently activate specific T lymphocytes. To regulate the immune responses, DCs have to mature by the recognition of TLR ligands, TNFα or IFNγ. These ligands have been used as adjuvants to activate DCs in situ or in vitro, with toxic effects. It has been shown that some molecules affect the immune system, e.g., Masticadienonic acid (MDA) and 3α-hydroxy masticadienoic acid (3α-OH MDA) triterpenes naturally occurring in several medicinal plants, since they activate the nitric oxide synthase in macrophages and induce T lymphocyte proliferation. The DCs maturation induced by MDA or 3a-OH MDA was determined by incubating these cells with MDA or 3α-OH MDA, and their phenotype was afterwards analyzed. The results showed that only 3α-OH MDA was able to induce DCs maturation. When mice with melanoma were inoculated with DCs/3α-OH MDA, a decreased tumor growth rate was observed along with an extended cell death area within tumors compared to mice treated with DCs incubated with MDA. In conclusion, it is proposed that 3α-OH MDA may be an immunostimulant molecule. Conversely, it is proposed that MDA may be a molecule with anti-inflammatory properties.https://www.mdpi.com/1420-3049/27/4/1451dendritic cellstriterpenescancer |
| spellingShingle | Gabriela Piñón-Zárate Fernanda Reyes-Riquelme Ma Beatriz Sánchez-Monroy Mónica Velasco-Torrez Mariano Martínez-Vázquez Christian Adrian Cárdenas-Monroy Beatriz Hernandez-Téllez Katia Jarquín-Yáñez Miguel Ángel Herrera-Enríquez Andrés Eliú Castell-Rodríguez Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells Molecules dendritic cells triterpenes cancer |
| title | Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells |
| title_full | Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells |
| title_fullStr | Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells |
| title_full_unstemmed | Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells |
| title_short | Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells |
| title_sort | immunomodulatory properties of masticadienonic acid and 3α hydroxy masticadienoic acid in dendritic cells |
| topic | dendritic cells triterpenes cancer |
| url | https://www.mdpi.com/1420-3049/27/4/1451 |
| work_keys_str_mv | AT gabrielapinonzarate immunomodulatorypropertiesofmasticadienonicacidand3ahydroxymasticadienoicacidindendriticcells AT fernandareyesriquelme immunomodulatorypropertiesofmasticadienonicacidand3ahydroxymasticadienoicacidindendriticcells AT mabeatrizsanchezmonroy immunomodulatorypropertiesofmasticadienonicacidand3ahydroxymasticadienoicacidindendriticcells AT monicavelascotorrez immunomodulatorypropertiesofmasticadienonicacidand3ahydroxymasticadienoicacidindendriticcells AT marianomartinezvazquez immunomodulatorypropertiesofmasticadienonicacidand3ahydroxymasticadienoicacidindendriticcells AT christianadriancardenasmonroy immunomodulatorypropertiesofmasticadienonicacidand3ahydroxymasticadienoicacidindendriticcells AT beatrizhernandeztellez immunomodulatorypropertiesofmasticadienonicacidand3ahydroxymasticadienoicacidindendriticcells AT katiajarquinyanez immunomodulatorypropertiesofmasticadienonicacidand3ahydroxymasticadienoicacidindendriticcells AT miguelangelherreraenriquez immunomodulatorypropertiesofmasticadienonicacidand3ahydroxymasticadienoicacidindendriticcells AT andreseliucastellrodriguez immunomodulatorypropertiesofmasticadienonicacidand3ahydroxymasticadienoicacidindendriticcells |