Role of FGF-18 in Bone Regeneration
In tissue engineering, three key components are cells, biological/mechanical cues, and scaffolds. Biological cues are normally proteins such as growth factors and their derivatives, bioactive molecules, and the regulators of a gene. Numerous growth factors such as VEGF, FGF, and TGF-β are being stud...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/1/36 |
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| author | Kavipriya Murugaiyan Sivashanmugam Amirthalingam Nathaniel Suk-Yeon Hwang Rangasamy Jayakumar |
| author_facet | Kavipriya Murugaiyan Sivashanmugam Amirthalingam Nathaniel Suk-Yeon Hwang Rangasamy Jayakumar |
| author_sort | Kavipriya Murugaiyan |
| collection | DOAJ |
| description | In tissue engineering, three key components are cells, biological/mechanical cues, and scaffolds. Biological cues are normally proteins such as growth factors and their derivatives, bioactive molecules, and the regulators of a gene. Numerous growth factors such as VEGF, FGF, and TGF-β are being studied and applied in different studies. The carriers used to release these growth factors also play an important role in their functioning. From the early part of the 1990s, more research has beenconductedon the role of fibroblast growth factors on the various physiological functions in our body. The fibroblast growth factor family contains 22 members. Fibroblast growth factors such as 2, 9, and 18 are mainly associated with the differentiation of osteoblasts and in bone regeneration. FGF-18 stimulates the PI3K/ERK pathway and smad1/5/8 pathway mediated via BMP-2 by blocking its antagonist, which is essential for bone formation. FGF-18 incorporated hydrogel and scaffolds had showed enhanced bone regeneration. This review highlights these functions and current trends using this growth factor and potential outcomes in the field of bone regeneration. |
| first_indexed | 2024-03-09T12:09:03Z |
| format | Article |
| id | doaj.art-cd545811068c4ea794edb08480ccc707 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T12:09:03Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-cd545811068c4ea794edb08480ccc7072023-11-30T22:55:08ZengMDPI AGJournal of Functional Biomaterials2079-49832023-01-011413610.3390/jfb14010036Role of FGF-18 in Bone RegenerationKavipriya Murugaiyan0Sivashanmugam Amirthalingam1Nathaniel Suk-Yeon Hwang2Rangasamy Jayakumar3Polymeric Biomaterials Lab, School of Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi 682041, IndiaInstitute of Engineering Research, Seoul National University, Seoul 08826, Republic of KoreaInstitute of Engineering Research, Seoul National University, Seoul 08826, Republic of KoreaPolymeric Biomaterials Lab, School of Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi 682041, IndiaIn tissue engineering, three key components are cells, biological/mechanical cues, and scaffolds. Biological cues are normally proteins such as growth factors and their derivatives, bioactive molecules, and the regulators of a gene. Numerous growth factors such as VEGF, FGF, and TGF-β are being studied and applied in different studies. The carriers used to release these growth factors also play an important role in their functioning. From the early part of the 1990s, more research has beenconductedon the role of fibroblast growth factors on the various physiological functions in our body. The fibroblast growth factor family contains 22 members. Fibroblast growth factors such as 2, 9, and 18 are mainly associated with the differentiation of osteoblasts and in bone regeneration. FGF-18 stimulates the PI3K/ERK pathway and smad1/5/8 pathway mediated via BMP-2 by blocking its antagonist, which is essential for bone formation. FGF-18 incorporated hydrogel and scaffolds had showed enhanced bone regeneration. This review highlights these functions and current trends using this growth factor and potential outcomes in the field of bone regeneration.https://www.mdpi.com/2079-4983/14/1/36fibroblasticgrowth factors (FGF)bone regenerationosteogenesisosseoconductionosseoinductionosseointegration |
| spellingShingle | Kavipriya Murugaiyan Sivashanmugam Amirthalingam Nathaniel Suk-Yeon Hwang Rangasamy Jayakumar Role of FGF-18 in Bone Regeneration Journal of Functional Biomaterials fibroblasticgrowth factors (FGF) bone regeneration osteogenesis osseoconduction osseoinduction osseointegration |
| title | Role of FGF-18 in Bone Regeneration |
| title_full | Role of FGF-18 in Bone Regeneration |
| title_fullStr | Role of FGF-18 in Bone Regeneration |
| title_full_unstemmed | Role of FGF-18 in Bone Regeneration |
| title_short | Role of FGF-18 in Bone Regeneration |
| title_sort | role of fgf 18 in bone regeneration |
| topic | fibroblasticgrowth factors (FGF) bone regeneration osteogenesis osseoconduction osseoinduction osseointegration |
| url | https://www.mdpi.com/2079-4983/14/1/36 |
| work_keys_str_mv | AT kavipriyamurugaiyan roleoffgf18inboneregeneration AT sivashanmugamamirthalingam roleoffgf18inboneregeneration AT nathanielsukyeonhwang roleoffgf18inboneregeneration AT rangasamyjayakumar roleoffgf18inboneregeneration |