Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility
The modification of medical devices is an area that has attracted a lot of attention in recent years; particularly, those developments which search to modify existing devices to render them antimicrobial. Most of these modifications involve at least two stages (modification of the base material with...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/10/2859 |
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| author | Marlene A. Velazco-Medel Luis A. Camacho-Cruz Héctor Magaña Kenia Palomino Emilio Bucio |
| author_facet | Marlene A. Velazco-Medel Luis A. Camacho-Cruz Héctor Magaña Kenia Palomino Emilio Bucio |
| author_sort | Marlene A. Velazco-Medel |
| collection | DOAJ |
| description | The modification of medical devices is an area that has attracted a lot of attention in recent years; particularly, those developments which search to modify existing devices to render them antimicrobial. Most of these modifications involve at least two stages (modification of the base material with a polymer graft and immobilization of an antimicrobial agent) which are both time-consuming and complicate synthetic procedures; therefore, as an improvement, this project sought to produce antimicrobial silicone (PDMS) in a single step. Using gamma radiation as both an energy source for polymerization initiation and as a source of reducing agents in solution, PDMS was simultaneously grafted with acrylic acid and ethylene glycol dimethacrylate (AAc:EGDMA) while producing antimicrobial silver nanoparticles (AgNPs) onto the surface of the material. To obtain reproducible materials, experimental variables such as the effect of the dose, the intensity of radiation, and the concentration of the silver salt were evaluated, finding the optimal reaction conditions to obtain materials with valuable properties. The characterization of the material was performed using electronic microscopy and spectroscopic techniques such as <sup>13</sup>C-CPMAS-SS-NMR and FTIR. Finally, these materials demonstrated good antimicrobial activity against <i>S. aureus</i> while retaining good cell viabilities (above 90%) for fibroblasts BALB/3T3. |
| first_indexed | 2024-03-10T11:31:04Z |
| format | Article |
| id | doaj.art-cd55168b84d44403b26db29599ba2803 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T11:31:04Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cd55168b84d44403b26db29599ba28032023-11-21T19:17:55ZengMDPI AGMolecules1420-30492021-05-012610285910.3390/molecules26102859Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and BiocompatibilityMarlene A. Velazco-Medel0Luis A. Camacho-Cruz1Héctor Magaña2Kenia Palomino3Emilio Bucio4Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad 7 Universitaria, Ciudad de México 04510, MexicoDepartamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad 7 Universitaria, Ciudad de México 04510, MexicoFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard No. 14418, Otay Mesa, Tijuana 22390, MexicoFaculty of Chemical Sciences and Engineering, Autonomous University of Baja California, University Boulevard No. 14418, Otay Mesa, Tijuana 22390, MexicoDepartamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad 7 Universitaria, Ciudad de México 04510, MexicoThe modification of medical devices is an area that has attracted a lot of attention in recent years; particularly, those developments which search to modify existing devices to render them antimicrobial. Most of these modifications involve at least two stages (modification of the base material with a polymer graft and immobilization of an antimicrobial agent) which are both time-consuming and complicate synthetic procedures; therefore, as an improvement, this project sought to produce antimicrobial silicone (PDMS) in a single step. Using gamma radiation as both an energy source for polymerization initiation and as a source of reducing agents in solution, PDMS was simultaneously grafted with acrylic acid and ethylene glycol dimethacrylate (AAc:EGDMA) while producing antimicrobial silver nanoparticles (AgNPs) onto the surface of the material. To obtain reproducible materials, experimental variables such as the effect of the dose, the intensity of radiation, and the concentration of the silver salt were evaluated, finding the optimal reaction conditions to obtain materials with valuable properties. The characterization of the material was performed using electronic microscopy and spectroscopic techniques such as <sup>13</sup>C-CPMAS-SS-NMR and FTIR. Finally, these materials demonstrated good antimicrobial activity against <i>S. aureus</i> while retaining good cell viabilities (above 90%) for fibroblasts BALB/3T3.https://www.mdpi.com/1420-3049/26/10/2859siliconegraftingsilver nanoparticlesradiationantimicrobialcytocompatibility |
| spellingShingle | Marlene A. Velazco-Medel Luis A. Camacho-Cruz Héctor Magaña Kenia Palomino Emilio Bucio Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility Molecules silicone grafting silver nanoparticles radiation antimicrobial cytocompatibility |
| title | Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility |
| title_full | Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility |
| title_fullStr | Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility |
| title_full_unstemmed | Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility |
| title_short | Simultaneous Grafting Polymerization of Acrylic Acid and Silver Aggregates Formation by Direct Reduction Using γ Radiation onto Silicone Surface and Their Antimicrobial Activity and Biocompatibility |
| title_sort | simultaneous grafting polymerization of acrylic acid and silver aggregates formation by direct reduction using γ radiation onto silicone surface and their antimicrobial activity and biocompatibility |
| topic | silicone grafting silver nanoparticles radiation antimicrobial cytocompatibility |
| url | https://www.mdpi.com/1420-3049/26/10/2859 |
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