Ataxic Severity Is Positively Correlated With Fatigue in Spinocerebellar Ataxia Type 3 Patients
Background: Spinocerebellar ataxia type 3 (SCA3) is an inherited form of ataxia that leads to progressive neurodegeneration. Fatigue is a common non-motor symptom in SCA3 and other neurodegenerative diseases, such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). Although ris...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00266/full |
| _version_ | 1828376695530323968 |
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| author | Jin-Shan Yang Hao-Ling Xu Ping-Ping Chen Arif Sikandar Mei-Zhen Qian Hui-Xia Lin Min-Ting Lin Wan-Jin Chen Ning Wang Hua Wu Shi-Rui Gan |
| author_facet | Jin-Shan Yang Hao-Ling Xu Ping-Ping Chen Arif Sikandar Mei-Zhen Qian Hui-Xia Lin Min-Ting Lin Wan-Jin Chen Ning Wang Hua Wu Shi-Rui Gan |
| author_sort | Jin-Shan Yang |
| collection | DOAJ |
| description | Background: Spinocerebellar ataxia type 3 (SCA3) is an inherited form of ataxia that leads to progressive neurodegeneration. Fatigue is a common non-motor symptom in SCA3 and other neurodegenerative diseases, such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). Although risk factors to fatigue in these diseases have been thoroughly studied, whether or not fatigue can affect clinical phenotypes has yet to be investigated.Methods: Ninety-one molecularly confirmed SCA3 patients and 85 age- and sex-matched controls were recruited for this study. The level of fatigue was measured using the 14-item Fatigue Scale (FS-14), and the risk factors to fatigue and how fatigue correlates with clinical phenotypes were studied using multivariable linear regression models.Results: We found that the severity was significantly higher in the SCA3 group than in the control group (9.30 ± 3.04% vs. 3.94 ± 2.66, P = 0.000). Daytime somnolence (β = 0.209, P = 0.002), severity of ataxia (β = 0.081, P = 0.006), and poor sleep quality (β = 0.187, P = 0.037) were found to have a positive relationship with fatigue. Although fatigue had no relationship with age at onset or ataxic progression, we found that it did have a positive relationship with the severity of ataxia (β = 7.009, P = 0.014).Conclusions: The high level of fatigue and the impact of fatigue on the clinical manifestation of SCA3 patients suggest that fatigue plays a large role in the pathogenesis of SCA3, thus demonstrating the need for intervention and treatment options in this patient cohort. |
| first_indexed | 2024-04-14T08:02:45Z |
| format | Article |
| id | doaj.art-cd5a74f912dd44feb92786838e3a0484 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-14T08:02:45Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-cd5a74f912dd44feb92786838e3a04842022-12-22T02:04:50ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-04-011110.3389/fneur.2020.00266507631Ataxic Severity Is Positively Correlated With Fatigue in Spinocerebellar Ataxia Type 3 PatientsJin-Shan YangHao-Ling XuPing-Ping ChenArif SikandarMei-Zhen QianHui-Xia LinMin-Ting LinWan-Jin ChenNing WangHua WuShi-Rui GanBackground: Spinocerebellar ataxia type 3 (SCA3) is an inherited form of ataxia that leads to progressive neurodegeneration. Fatigue is a common non-motor symptom in SCA3 and other neurodegenerative diseases, such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). Although risk factors to fatigue in these diseases have been thoroughly studied, whether or not fatigue can affect clinical phenotypes has yet to be investigated.Methods: Ninety-one molecularly confirmed SCA3 patients and 85 age- and sex-matched controls were recruited for this study. The level of fatigue was measured using the 14-item Fatigue Scale (FS-14), and the risk factors to fatigue and how fatigue correlates with clinical phenotypes were studied using multivariable linear regression models.Results: We found that the severity was significantly higher in the SCA3 group than in the control group (9.30 ± 3.04% vs. 3.94 ± 2.66, P = 0.000). Daytime somnolence (β = 0.209, P = 0.002), severity of ataxia (β = 0.081, P = 0.006), and poor sleep quality (β = 0.187, P = 0.037) were found to have a positive relationship with fatigue. Although fatigue had no relationship with age at onset or ataxic progression, we found that it did have a positive relationship with the severity of ataxia (β = 7.009, P = 0.014).Conclusions: The high level of fatigue and the impact of fatigue on the clinical manifestation of SCA3 patients suggest that fatigue plays a large role in the pathogenesis of SCA3, thus demonstrating the need for intervention and treatment options in this patient cohort.https://www.frontiersin.org/article/10.3389/fneur.2020.00266/fullfatiguespinocerebellar ataxia type 3neurodegenerationclinical manifestationataxic severity |
| spellingShingle | Jin-Shan Yang Hao-Ling Xu Ping-Ping Chen Arif Sikandar Mei-Zhen Qian Hui-Xia Lin Min-Ting Lin Wan-Jin Chen Ning Wang Hua Wu Shi-Rui Gan Ataxic Severity Is Positively Correlated With Fatigue in Spinocerebellar Ataxia Type 3 Patients Frontiers in Neurology fatigue spinocerebellar ataxia type 3 neurodegeneration clinical manifestation ataxic severity |
| title | Ataxic Severity Is Positively Correlated With Fatigue in Spinocerebellar Ataxia Type 3 Patients |
| title_full | Ataxic Severity Is Positively Correlated With Fatigue in Spinocerebellar Ataxia Type 3 Patients |
| title_fullStr | Ataxic Severity Is Positively Correlated With Fatigue in Spinocerebellar Ataxia Type 3 Patients |
| title_full_unstemmed | Ataxic Severity Is Positively Correlated With Fatigue in Spinocerebellar Ataxia Type 3 Patients |
| title_short | Ataxic Severity Is Positively Correlated With Fatigue in Spinocerebellar Ataxia Type 3 Patients |
| title_sort | ataxic severity is positively correlated with fatigue in spinocerebellar ataxia type 3 patients |
| topic | fatigue spinocerebellar ataxia type 3 neurodegeneration clinical manifestation ataxic severity |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00266/full |
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