Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case report
Pulmonary strongyloidiasis is a rare infection in patients with autoimmune diseases, and immunosuppression can lead to the development of hyperinfection syndrome with a high mortality rate. We present a case of a 78-year-old male with previous idiopathic inflammatory myopathy (IIM) with interstitial...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402310692X |
| _version_ | 1797337056050937856 |
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| author | Wei Fan Qiong Fu Yuetian Yu |
| author_facet | Wei Fan Qiong Fu Yuetian Yu |
| author_sort | Wei Fan |
| collection | DOAJ |
| description | Pulmonary strongyloidiasis is a rare infection in patients with autoimmune diseases, and immunosuppression can lead to the development of hyperinfection syndrome with a high mortality rate. We present a case of a 78-year-old male with previous idiopathic inflammatory myopathy (IIM) with interstitial lung disease. He developed hyperinfection syndrome and respiratory failure, and diagnostic metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) confirmed the presence of Strongyloides stercoralis. After treatment with ivermectin, the patient's symptoms improved. Therefore, adequate screening and prophylactic treatment are needed for people at risk of immunosuppression, which can reduce the occurrence of the devastating S. stercoralis hyperinfection syndrome. It also highlights mNGS as a highly accurate test for the detection of difficult to atypical pathogens. |
| first_indexed | 2024-03-08T09:03:52Z |
| format | Article |
| id | doaj.art-cd5ac556c16e40c48556e3c04fe58544 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T09:03:52Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-cd5ac556c16e40c48556e3c04fe585442024-02-01T06:32:05ZengElsevierHeliyon2405-84402024-01-01101e23484Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case reportWei Fan0Qiong Fu1Yuetian Yu2Department of Rheumatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Rheumatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Critical Care Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding author.Pulmonary strongyloidiasis is a rare infection in patients with autoimmune diseases, and immunosuppression can lead to the development of hyperinfection syndrome with a high mortality rate. We present a case of a 78-year-old male with previous idiopathic inflammatory myopathy (IIM) with interstitial lung disease. He developed hyperinfection syndrome and respiratory failure, and diagnostic metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) confirmed the presence of Strongyloides stercoralis. After treatment with ivermectin, the patient's symptoms improved. Therefore, adequate screening and prophylactic treatment are needed for people at risk of immunosuppression, which can reduce the occurrence of the devastating S. stercoralis hyperinfection syndrome. It also highlights mNGS as a highly accurate test for the detection of difficult to atypical pathogens.http://www.sciencedirect.com/science/article/pii/S240584402310692XStrongyloides stercoralisIdiopathic inflammatory myopathyHyperinfection syndromeMetagenomic next-generation sequencingCase report |
| spellingShingle | Wei Fan Qiong Fu Yuetian Yu Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case report Heliyon Strongyloides stercoralis Idiopathic inflammatory myopathy Hyperinfection syndrome Metagenomic next-generation sequencing Case report |
| title | Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case report |
| title_full | Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case report |
| title_fullStr | Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case report |
| title_full_unstemmed | Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case report |
| title_short | Pulmonary strongyloidiasis and hyperinfection in a Patient with idiopathic inflammatory myopathy：A case report |
| title_sort | pulmonary strongyloidiasis and hyperinfection in a patient with idiopathic inflammatory myopathy a case report |
| topic | Strongyloides stercoralis Idiopathic inflammatory myopathy Hyperinfection syndrome Metagenomic next-generation sequencing Case report |
| url | http://www.sciencedirect.com/science/article/pii/S240584402310692X |
| work_keys_str_mv | AT weifan pulmonarystrongyloidiasisandhyperinfectioninapatientwithidiopathicinflammatorymyopathyacasereport AT qiongfu pulmonarystrongyloidiasisandhyperinfectioninapatientwithidiopathicinflammatorymyopathyacasereport AT yuetianyu pulmonarystrongyloidiasisandhyperinfectioninapatientwithidiopathicinflammatorymyopathyacasereport |