The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors
Increased glycolysis is a key characteristic of malignant cells that contributes to their high proliferation rates and ability to develop drug resistance. The glycolysis rate-limiting enzyme hexokinase II (HK II) is overexpressed in most tumor cells and significantly affects tumor development. This...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/1/75 |
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| author | Bingru Liu Yu Lu Ayijiang Taledaohan Shi Qiao Qingyan Li Yuji Wang |
| author_facet | Bingru Liu Yu Lu Ayijiang Taledaohan Shi Qiao Qingyan Li Yuji Wang |
| author_sort | Bingru Liu |
| collection | DOAJ |
| description | Increased glycolysis is a key characteristic of malignant cells that contributes to their high proliferation rates and ability to develop drug resistance. The glycolysis rate-limiting enzyme hexokinase II (HK II) is overexpressed in most tumor cells and significantly affects tumor development. This paper examines the structure of HK II and the specific biological factors that influence its role in tumor development, as well as the potential of HK II inhibitors in antitumor therapy. Furthermore, we identify and discuss the inhibitors of HK II that have been reported in the literature. |
| first_indexed | 2024-03-08T15:01:46Z |
| format | Article |
| id | doaj.art-cd5bb1b42cd54043abec8cb723d49f9c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-08T15:01:46Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cd5bb1b42cd54043abec8cb723d49f9c2024-01-10T15:04:04ZengMDPI AGMolecules1420-30492023-12-012917510.3390/molecules29010075The Promoting Role of HK II in Tumor Development and the Research Progress of Its InhibitorsBingru Liu0Yu Lu1Ayijiang Taledaohan2Shi Qiao3Qingyan Li4Yuji Wang5Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing 100069, ChinaDepartment of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing 100069, ChinaDepartment of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing 100069, ChinaCivil Aviation Medical Center, Civil Aviation Administration of China, Beijing 100123, ChinaCivil Aviation Medical Center, Civil Aviation Administration of China, Beijing 100123, ChinaDepartment of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing 100069, ChinaIncreased glycolysis is a key characteristic of malignant cells that contributes to their high proliferation rates and ability to develop drug resistance. The glycolysis rate-limiting enzyme hexokinase II (HK II) is overexpressed in most tumor cells and significantly affects tumor development. This paper examines the structure of HK II and the specific biological factors that influence its role in tumor development, as well as the potential of HK II inhibitors in antitumor therapy. Furthermore, we identify and discuss the inhibitors of HK II that have been reported in the literature.https://www.mdpi.com/1420-3049/29/1/75hexokinase IIantitumorWarburg effectglycolysisinhibitors |
| spellingShingle | Bingru Liu Yu Lu Ayijiang Taledaohan Shi Qiao Qingyan Li Yuji Wang The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors Molecules hexokinase II antitumor Warburg effect glycolysis inhibitors |
| title | The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors |
| title_full | The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors |
| title_fullStr | The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors |
| title_full_unstemmed | The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors |
| title_short | The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors |
| title_sort | promoting role of hk ii in tumor development and the research progress of its inhibitors |
| topic | hexokinase II antitumor Warburg effect glycolysis inhibitors |
| url | https://www.mdpi.com/1420-3049/29/1/75 |
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