Reactivation of SARS-CoV-2 infection following recovery from COVID-19
Introduction: Many individuals test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA after recovering from the coronavirus disease (COVID-19), but the incidence of reactivation is unknown. We, therefore, estimated the incidence of reactivation among individuals who had r...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-05-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034121000320 |
| _version_ | 1818720484731125760 |
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| author | Zhihai Chen Wen Xie Ziruo Ge Yajie Wang Hong Zhao Jingjing Wang Yanli Xu Wei Zhang Meihua Song Shuping Cui Xiankun Wang Calvin Q. Pan |
| author_facet | Zhihai Chen Wen Xie Ziruo Ge Yajie Wang Hong Zhao Jingjing Wang Yanli Xu Wei Zhang Meihua Song Shuping Cui Xiankun Wang Calvin Q. Pan |
| author_sort | Zhihai Chen |
| collection | DOAJ |
| description | Introduction: Many individuals test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA after recovering from the coronavirus disease (COVID-19), but the incidence of reactivation is unknown. We, therefore, estimated the incidence of reactivation among individuals who had recovered from COVID-19 and determined its predictors. Methods: In this retrospective cohort study, patients with COVID-19 were followed up for at least 14 days after two consecutive negative SARS-CoV-2 polymerase chain reaction test results obtained ≥24 h apart, and the frequency of SARS-CoV-2 reactivation was assessed. Results: Of the 109 patients, 29 (27%) experienced reactivation, and seven (24%) of these were symptomatic. The mean period for the real-time PCR tests for SARS-CoV-2 from negative to positive results was 17 days. Compared with patients without reactivation, those with reactivation were significantly younger and more likely to have a lymphocyte count of <1500/μL (odds ratio [OR]: 0.34, 95% confidence interval [CI]: 0.12–0.94) and two or fewer symptoms (OR: 0.20, 95% CI: 0.07–0.55) during the initial episode. Conclusion: Risk-stratified surveillance should be conducted among patients who have recovered from COVID-19. |
| first_indexed | 2024-12-17T20:23:34Z |
| format | Article |
| id | doaj.art-cd5c40a74aee477e9318eb5999a033ba |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-17T20:23:34Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-cd5c40a74aee477e9318eb5999a033ba2022-12-21T21:33:52ZengElsevierJournal of Infection and Public Health1876-03412021-05-01145620627Reactivation of SARS-CoV-2 infection following recovery from COVID-19Zhihai Chen0Wen Xie1Ziruo Ge2Yajie Wang3Hong Zhao4Jingjing Wang5Yanli Xu6Wei Zhang7Meihua Song8Shuping Cui9Xiankun Wang10Calvin Q. Pan11Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, PR ChinaCenter of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8, Jingshun East Street, Chaoyang District, Beijing 100015, PR ChinaCenter of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, PR China; Graduate School of Capital Medical University, Beijing, PR ChinaDepartment of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, PR ChinaCenter of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8, Jingshun East Street, Chaoyang District, Beijing 100015, PR ChinaCenter of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8, Jingshun East Street, Chaoyang District, Beijing 100015, PR ChinaCenter of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, PR ChinaCenter of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, PR ChinaCenter of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, PR ChinaCenter of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, PR China; Peking University Ditan Teaching Hospital, Peking University, Beijing, ChinaCenter of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, PR China; Graduate School of Capital Medical University, Beijing, PR ChinaCenter of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, No. 8, Jingshun East Street, Chaoyang District, Beijing 100015, PR China; Corresponding author.Introduction: Many individuals test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA after recovering from the coronavirus disease (COVID-19), but the incidence of reactivation is unknown. We, therefore, estimated the incidence of reactivation among individuals who had recovered from COVID-19 and determined its predictors. Methods: In this retrospective cohort study, patients with COVID-19 were followed up for at least 14 days after two consecutive negative SARS-CoV-2 polymerase chain reaction test results obtained ≥24 h apart, and the frequency of SARS-CoV-2 reactivation was assessed. Results: Of the 109 patients, 29 (27%) experienced reactivation, and seven (24%) of these were symptomatic. The mean period for the real-time PCR tests for SARS-CoV-2 from negative to positive results was 17 days. Compared with patients without reactivation, those with reactivation were significantly younger and more likely to have a lymphocyte count of <1500/μL (odds ratio [OR]: 0.34, 95% confidence interval [CI]: 0.12–0.94) and two or fewer symptoms (OR: 0.20, 95% CI: 0.07–0.55) during the initial episode. Conclusion: Risk-stratified surveillance should be conducted among patients who have recovered from COVID-19.http://www.sciencedirect.com/science/article/pii/S1876034121000320Coronavirus reactivationCOVID-19 relapsePersistent coronavirus infectionReal-Time reverse transcription-polymerase chain reactionRecurrent SARS-CoV-2 infection |
| spellingShingle | Zhihai Chen Wen Xie Ziruo Ge Yajie Wang Hong Zhao Jingjing Wang Yanli Xu Wei Zhang Meihua Song Shuping Cui Xiankun Wang Calvin Q. Pan Reactivation of SARS-CoV-2 infection following recovery from COVID-19 Journal of Infection and Public Health Coronavirus reactivation COVID-19 relapse Persistent coronavirus infection Real-Time reverse transcription-polymerase chain reaction Recurrent SARS-CoV-2 infection |
| title | Reactivation of SARS-CoV-2 infection following recovery from COVID-19 |
| title_full | Reactivation of SARS-CoV-2 infection following recovery from COVID-19 |
| title_fullStr | Reactivation of SARS-CoV-2 infection following recovery from COVID-19 |
| title_full_unstemmed | Reactivation of SARS-CoV-2 infection following recovery from COVID-19 |
| title_short | Reactivation of SARS-CoV-2 infection following recovery from COVID-19 |
| title_sort | reactivation of sars cov 2 infection following recovery from covid 19 |
| topic | Coronavirus reactivation COVID-19 relapse Persistent coronavirus infection Real-Time reverse transcription-polymerase chain reaction Recurrent SARS-CoV-2 infection |
| url | http://www.sciencedirect.com/science/article/pii/S1876034121000320 |
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