Regenerative capacity of dental pulp stem cells: A systematic review
Objectives: The dental pulp contains undifferentiated mesenchymal cells, blood vessels and so on, which are responsible for routine functions of a tooth. The determination of stemness and regenerative properties using biomarkers and further application in routine practice may unravel its potential....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=5;spage=27;epage=36;aulast=Rosaian |
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| author | Adlin S Rosaian Gururaj Narayana Rao Sunil P Mohan Mahalakshmi Vijayarajan Rebekkah C Prabhakaran Anand Sherwood |
| author_facet | Adlin S Rosaian Gururaj Narayana Rao Sunil P Mohan Mahalakshmi Vijayarajan Rebekkah C Prabhakaran Anand Sherwood |
| author_sort | Adlin S Rosaian |
| collection | DOAJ |
| description | Objectives: The dental pulp contains undifferentiated mesenchymal cells, blood vessels and so on, which are responsible for routine functions of a tooth. The determination of stemness and regenerative properties using biomarkers and further application in routine practice may unravel its potential. Materials and Methods: Inclusion criteria—original research articles published in English, from 2000 to 2019, were collected both manually and by electronic search from databases of Cochrane, Medline, Embase, and PubMed. Exclusion criteria—articles other than English and review manuscripts were omitted. The shortlisted articles were reviewed for specific biomarkers, to assess the regenerative potential, stemness, and lineage of dental pulp stem cells. Results: Of 512 articles, 64 were selected and reviewed to determine the mesenchymal, neurogenic, vasculogenic, hematopoietic, and stem cell potential. On the basis of the search analysis, a panel of markers was proposed. Conclusion: The application of proposed markers, on a pulpectomized tissue derived from human teeth, may be helpful to determine the regenerative potential and the usefulness in regenerative medicine and tissue engineering. |
| first_indexed | 2024-12-11T05:50:45Z |
| format | Article |
| id | doaj.art-cd605c8ccca4405e892a3b5841e8aa11 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-12-11T05:50:45Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-cd605c8ccca4405e892a3b5841e8aa112022-12-22T01:18:49ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062020-01-01125273610.4103/jpbs.JPBS_121_20Regenerative capacity of dental pulp stem cells: A systematic reviewAdlin S RosaianGururaj Narayana RaoSunil P MohanMahalakshmi VijayarajanRebekkah C PrabhakaranAnand SherwoodObjectives: The dental pulp contains undifferentiated mesenchymal cells, blood vessels and so on, which are responsible for routine functions of a tooth. The determination of stemness and regenerative properties using biomarkers and further application in routine practice may unravel its potential. Materials and Methods: Inclusion criteria—original research articles published in English, from 2000 to 2019, were collected both manually and by electronic search from databases of Cochrane, Medline, Embase, and PubMed. Exclusion criteria—articles other than English and review manuscripts were omitted. The shortlisted articles were reviewed for specific biomarkers, to assess the regenerative potential, stemness, and lineage of dental pulp stem cells. Results: Of 512 articles, 64 were selected and reviewed to determine the mesenchymal, neurogenic, vasculogenic, hematopoietic, and stem cell potential. On the basis of the search analysis, a panel of markers was proposed. Conclusion: The application of proposed markers, on a pulpectomized tissue derived from human teeth, may be helpful to determine the regenerative potential and the usefulness in regenerative medicine and tissue engineering.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=5;spage=27;epage=36;aulast=Rosaianbiomarkersdental pulp stem cellsregenerative medicinestem cellstissue engineering |
| spellingShingle | Adlin S Rosaian Gururaj Narayana Rao Sunil P Mohan Mahalakshmi Vijayarajan Rebekkah C Prabhakaran Anand Sherwood Regenerative capacity of dental pulp stem cells: A systematic review Journal of Pharmacy and Bioallied Sciences biomarkers dental pulp stem cells regenerative medicine stem cells tissue engineering |
| title | Regenerative capacity of dental pulp stem cells: A systematic review |
| title_full | Regenerative capacity of dental pulp stem cells: A systematic review |
| title_fullStr | Regenerative capacity of dental pulp stem cells: A systematic review |
| title_full_unstemmed | Regenerative capacity of dental pulp stem cells: A systematic review |
| title_short | Regenerative capacity of dental pulp stem cells: A systematic review |
| title_sort | regenerative capacity of dental pulp stem cells a systematic review |
| topic | biomarkers dental pulp stem cells regenerative medicine stem cells tissue engineering |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2020;volume=12;issue=5;spage=27;epage=36;aulast=Rosaian |
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