Effect of bacterial resistant zwitterionic derivative incorporation on the physical properties of resin-modified glass ionomer luting cement
Abstract Biofilms induce microbial-mediated surface roughening and deterioration of cement. In this study, zwitterionic derivatives (ZD) of sulfobetaine methacrylate (SBMA) and 2-methacryloyloxyethyl phosphorylcholine, were added in concentrations of 0, 1, and 3% to three different types of commerci...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-30670-4 |
| _version_ | 1797864932265426944 |
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| author | Chengzan Wu Min-Ji Kim Utkarsh Mangal Ji-Young Seo Ji-Yeong Kim Junho Kim Ju-Young Park Jae-Sung Kwon Sung-Hwan Choi |
| author_facet | Chengzan Wu Min-Ji Kim Utkarsh Mangal Ji-Young Seo Ji-Yeong Kim Junho Kim Ju-Young Park Jae-Sung Kwon Sung-Hwan Choi |
| author_sort | Chengzan Wu |
| collection | DOAJ |
| description | Abstract Biofilms induce microbial-mediated surface roughening and deterioration of cement. In this study, zwitterionic derivatives (ZD) of sulfobetaine methacrylate (SBMA) and 2-methacryloyloxyethyl phosphorylcholine, were added in concentrations of 0, 1, and 3% to three different types of commercially available resin-modified glass ionomer cement (RMGIC) (RMC-I: RelyX Luting 2, RMC-II: Nexus RMGI, and RMC-III: GC FujiCEM 2). The unmodified RMGICs served as the control group for comparison. The resistance of Streptococcus mutans to ZD-modified RMGIC was evaluated with a monoculture biofilm assay. The following physical properties of the ZD-modified RMGIC were assessed: wettability, film thickness, flexural strength, elastic modulus, shear bond strength, and failure mode. The ZD-modified RMGIC significantly inhibited biofilm formation, with at least a 30% reduction compared to the control group. The addition of ZD improved the wettability of RMGIC; however, only 3% of the SBMA group was statistically different (P < 0.05). The film thickness increased in proportion to the increasing ZD concentrations; there was no statistical difference within the RMC-I (P > 0.05). The experimental groups' flexural strength, elastic modulus, and shear bond strength showed an insignificant decrease from the control group; there was no statistical difference within the RMC-I (P > 0.05). The mode of failure differed slightly in each group, but all groups showed dominance in the adhesive and mixed failure. Thus, the addition of 1 wt.% ZD in RMGIC favorably enhanced the resistance to Streptococcus mutans without any tangible loss in flexural and shear bond strength. |
| first_indexed | 2024-04-09T22:59:55Z |
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| id | doaj.art-cd6142f0e3fb425d93a07753233d7e7b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:59:55Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cd6142f0e3fb425d93a07753233d7e7b2023-03-22T11:03:11ZengNature PortfolioScientific Reports2045-23222023-03-0113111110.1038/s41598-023-30670-4Effect of bacterial resistant zwitterionic derivative incorporation on the physical properties of resin-modified glass ionomer luting cementChengzan Wu0Min-Ji Kim1Utkarsh Mangal2Ji-Young Seo3Ji-Yeong Kim4Junho Kim5Ju-Young Park6Jae-Sung Kwon7Sung-Hwan Choi8Department of Orthodontics and Institute of Craniofacial Deformity, Yonsei University College of DentistryDivision in Anatomy and Developmental Biology, Department of Oral Biology, Yonsei University College of DentistryDepartment of Orthodontics and Institute of Craniofacial Deformity, Yonsei University College of DentistryInstitute of Craniofacial Deformity, Yonsei University College of DentistryInstitute of Craniofacial Deformity, Yonsei University College of DentistryInstitute of Craniofacial Deformity, Yonsei University College of DentistryDepartment and Research Institute of Dental Biomaterials and Bioengineering, BK21 PLUS Project, Yonsei University College of DentistryBK21 FOUR Project, Yonsei University College of DentistryDepartment of Orthodontics and Institute of Craniofacial Deformity, Yonsei University College of DentistryAbstract Biofilms induce microbial-mediated surface roughening and deterioration of cement. In this study, zwitterionic derivatives (ZD) of sulfobetaine methacrylate (SBMA) and 2-methacryloyloxyethyl phosphorylcholine, were added in concentrations of 0, 1, and 3% to three different types of commercially available resin-modified glass ionomer cement (RMGIC) (RMC-I: RelyX Luting 2, RMC-II: Nexus RMGI, and RMC-III: GC FujiCEM 2). The unmodified RMGICs served as the control group for comparison. The resistance of Streptococcus mutans to ZD-modified RMGIC was evaluated with a monoculture biofilm assay. The following physical properties of the ZD-modified RMGIC were assessed: wettability, film thickness, flexural strength, elastic modulus, shear bond strength, and failure mode. The ZD-modified RMGIC significantly inhibited biofilm formation, with at least a 30% reduction compared to the control group. The addition of ZD improved the wettability of RMGIC; however, only 3% of the SBMA group was statistically different (P < 0.05). The film thickness increased in proportion to the increasing ZD concentrations; there was no statistical difference within the RMC-I (P > 0.05). The experimental groups' flexural strength, elastic modulus, and shear bond strength showed an insignificant decrease from the control group; there was no statistical difference within the RMC-I (P > 0.05). The mode of failure differed slightly in each group, but all groups showed dominance in the adhesive and mixed failure. Thus, the addition of 1 wt.% ZD in RMGIC favorably enhanced the resistance to Streptococcus mutans without any tangible loss in flexural and shear bond strength.https://doi.org/10.1038/s41598-023-30670-4 |
| spellingShingle | Chengzan Wu Min-Ji Kim Utkarsh Mangal Ji-Young Seo Ji-Yeong Kim Junho Kim Ju-Young Park Jae-Sung Kwon Sung-Hwan Choi Effect of bacterial resistant zwitterionic derivative incorporation on the physical properties of resin-modified glass ionomer luting cement Scientific Reports |
| title | Effect of bacterial resistant zwitterionic derivative incorporation on the physical properties of resin-modified glass ionomer luting cement |
| title_full | Effect of bacterial resistant zwitterionic derivative incorporation on the physical properties of resin-modified glass ionomer luting cement |
| title_fullStr | Effect of bacterial resistant zwitterionic derivative incorporation on the physical properties of resin-modified glass ionomer luting cement |
| title_full_unstemmed | Effect of bacterial resistant zwitterionic derivative incorporation on the physical properties of resin-modified glass ionomer luting cement |
| title_short | Effect of bacterial resistant zwitterionic derivative incorporation on the physical properties of resin-modified glass ionomer luting cement |
| title_sort | effect of bacterial resistant zwitterionic derivative incorporation on the physical properties of resin modified glass ionomer luting cement |
| url | https://doi.org/10.1038/s41598-023-30670-4 |
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