Crosstalk between glial and glioblastoma cells triggers the “go-or-grow” phenotype of tumor cells

Crosstalk between glial and glioblastoma cells triggers the “go-or-grow” phenotype of tumor cells

Abstract Background Glioblastoma (GBM), the most malignant primary brain tumor, leads to poor and unpredictable clinical outcomes. Recent studies showed the tumor microenvironment has a critical role in regulating tumor growth by establishing a complex network of interactions with tumor cells. In th...

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Bibliographic Details
Main Authors: Ana Isabel Oliveira, Sandra I. Anjo, Joana Vieira de Castro, Sofia C. Serra, António J. Salgado, Bruno Manadas, Bruno M. Costa
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Cell Communication and Signaling
Subjects:
Glioblastoma
Glial cells
Tumor microenvironment
Secretome
Paracrine effect
Online Access:http://link.springer.com/article/10.1186/s12964-017-0194-x

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