Gastroparesis might not be uncommon in patients with diabetes mellitus in a real-world clinical setting: a cohort study
Abstract Background This study investigated the frequency of diabetic gastroparesis and associated risk factors in a real-world clinical setting. Methods This retrospective cross-sectional study included patients who underwent assessments of solid gastric emptying time (GET) by technetium-99 m scint...
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| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-023-03106-6 |
| _version_ | 1827382159748366336 |
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| author | Jeongmin Lee Hye Lim Park Su Young Park Chul-Hyun Lim Min-Hee Kim Jung Min Lee Sang-Ah Chang Jung-Hwan Oh |
| author_facet | Jeongmin Lee Hye Lim Park Su Young Park Chul-Hyun Lim Min-Hee Kim Jung Min Lee Sang-Ah Chang Jung-Hwan Oh |
| author_sort | Jeongmin Lee |
| collection | DOAJ |
| description | Abstract Background This study investigated the frequency of diabetic gastroparesis and associated risk factors in a real-world clinical setting. Methods This retrospective cross-sectional study included patients who underwent assessments of solid gastric emptying time (GET) by technetium-99 m scintigraphy between May 2019 and December 2020. We categorized patients into three groups according to gastric retention of technetium-99 m: rapid (< 65% at 1 h or < 20% at 2 h), normal (≤60% at 2 h and/or ≤ 10% at 4 h), and delayed (> 60% at 2 h and/or > 10% at 4 h). Results Patients with diabetes mellitus (DM) were more likely to show abnormal GET than those without DM (119 [70.8%] vs. 16 [44.4%]). The mean glycated A1c was 10.3% in DM patients. DM patients with normal GET were significantly younger (57.2 years, P = 0.044) than those with delayed (65.0 years) or rapid GET (60.2 years). Fasting glucose levels were the lowest in the normal GET group and the highest in the rapid GET group (delayed: 176.3 mg/dL, normal: 151.2 mg/dL, rapid: 181.0 mg/dL, P = 0.030). However, glycated A1c was not significantly different among the delayed, normal, and rapid GET groups in patients with DM. Patients with delayed and rapid GET showed a higher frequency of retinopathy (6.0 vs. 15.5%, P = 0.001) and peripheral neuropathy (11.3 vs. 24.4%, P = 0.001) than those with normal GET. In the multinomial logistic regression analysis, retinopathy demonstrated a positive association with delayed GET, while nephropathy showed a significant negative correlation. Conclusion DM gastroparesis in the clinical setting was not uncommon. Abnormal GET, including delayed and rapid GET, was associated with DM retinopathy or peripheral neuropathy. |
| first_indexed | 2024-03-08T14:15:32Z |
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| id | doaj.art-cd6677c593af4a5289e78c75727c5766 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-08T14:15:32Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-cd6677c593af4a5289e78c75727c57662024-01-14T12:25:13ZengBMCBMC Gastroenterology1471-230X2024-01-012411910.1186/s12876-023-03106-6Gastroparesis might not be uncommon in patients with diabetes mellitus in a real-world clinical setting: a cohort studyJeongmin Lee0Hye Lim Park1Su Young Park2Chul-Hyun Lim3Min-Hee Kim4Jung Min Lee5Sang-Ah Chang6Jung-Hwan Oh7Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Nuclear medicine, Department of Radiology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Nuclear medicine, Department of Radiology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Gastroenterology, Department of Internal Medicine, The Catholic University of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Gastroenterology, Department of Internal Medicine, The Catholic University of KoreaAbstract Background This study investigated the frequency of diabetic gastroparesis and associated risk factors in a real-world clinical setting. Methods This retrospective cross-sectional study included patients who underwent assessments of solid gastric emptying time (GET) by technetium-99 m scintigraphy between May 2019 and December 2020. We categorized patients into three groups according to gastric retention of technetium-99 m: rapid (< 65% at 1 h or < 20% at 2 h), normal (≤60% at 2 h and/or ≤ 10% at 4 h), and delayed (> 60% at 2 h and/or > 10% at 4 h). Results Patients with diabetes mellitus (DM) were more likely to show abnormal GET than those without DM (119 [70.8%] vs. 16 [44.4%]). The mean glycated A1c was 10.3% in DM patients. DM patients with normal GET were significantly younger (57.2 years, P = 0.044) than those with delayed (65.0 years) or rapid GET (60.2 years). Fasting glucose levels were the lowest in the normal GET group and the highest in the rapid GET group (delayed: 176.3 mg/dL, normal: 151.2 mg/dL, rapid: 181.0 mg/dL, P = 0.030). However, glycated A1c was not significantly different among the delayed, normal, and rapid GET groups in patients with DM. Patients with delayed and rapid GET showed a higher frequency of retinopathy (6.0 vs. 15.5%, P = 0.001) and peripheral neuropathy (11.3 vs. 24.4%, P = 0.001) than those with normal GET. In the multinomial logistic regression analysis, retinopathy demonstrated a positive association with delayed GET, while nephropathy showed a significant negative correlation. Conclusion DM gastroparesis in the clinical setting was not uncommon. Abnormal GET, including delayed and rapid GET, was associated with DM retinopathy or peripheral neuropathy.https://doi.org/10.1186/s12876-023-03106-6Diabetes mellitusDiabetic neuropathiesGastroparesisGastric emptyingRadionuclide imaging |
| spellingShingle | Jeongmin Lee Hye Lim Park Su Young Park Chul-Hyun Lim Min-Hee Kim Jung Min Lee Sang-Ah Chang Jung-Hwan Oh Gastroparesis might not be uncommon in patients with diabetes mellitus in a real-world clinical setting: a cohort study BMC Gastroenterology Diabetes mellitus Diabetic neuropathies Gastroparesis Gastric emptying Radionuclide imaging |
| title | Gastroparesis might not be uncommon in patients with diabetes mellitus in a real-world clinical setting: a cohort study |
| title_full | Gastroparesis might not be uncommon in patients with diabetes mellitus in a real-world clinical setting: a cohort study |
| title_fullStr | Gastroparesis might not be uncommon in patients with diabetes mellitus in a real-world clinical setting: a cohort study |
| title_full_unstemmed | Gastroparesis might not be uncommon in patients with diabetes mellitus in a real-world clinical setting: a cohort study |
| title_short | Gastroparesis might not be uncommon in patients with diabetes mellitus in a real-world clinical setting: a cohort study |
| title_sort | gastroparesis might not be uncommon in patients with diabetes mellitus in a real world clinical setting a cohort study |
| topic | Diabetes mellitus Diabetic neuropathies Gastroparesis Gastric emptying Radionuclide imaging |
| url | https://doi.org/10.1186/s12876-023-03106-6 |
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