Risk of thrombotic complications in influenza versus COVID‐19 hospitalized patients
Abstract Background Whereas accumulating studies on patients with coronavirus disease 2019 (COVID‐19) report high incidences of thrombotic complications, large studies on clinically relevant thrombosis in patients with other respiratory tract infections are lacking. How this high risk in COVID‐19 pa...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rth2.12496 |
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| author | Milou A. M. Stals Marco J. J. H. Grootenboers Coen vanGuldener Fleur H. J. Kaptein Sander J. E. Braken Qingui Chen Gordon Chu Erik M. vanDriel Antonio Iglesias del Sol Evert deJonge K. Merijn Kant Fleur Pals Myrthe M. A. Toorop Suzanne C. Cannegieter Frederikus A. Klok Menno V. Huisman the Dutch COVID & Thrombosis Coalition (DCTC) |
| author_facet | Milou A. M. Stals Marco J. J. H. Grootenboers Coen vanGuldener Fleur H. J. Kaptein Sander J. E. Braken Qingui Chen Gordon Chu Erik M. vanDriel Antonio Iglesias del Sol Evert deJonge K. Merijn Kant Fleur Pals Myrthe M. A. Toorop Suzanne C. Cannegieter Frederikus A. Klok Menno V. Huisman the Dutch COVID & Thrombosis Coalition (DCTC) |
| author_sort | Milou A. M. Stals |
| collection | DOAJ |
| description | Abstract Background Whereas accumulating studies on patients with coronavirus disease 2019 (COVID‐19) report high incidences of thrombotic complications, large studies on clinically relevant thrombosis in patients with other respiratory tract infections are lacking. How this high risk in COVID‐19 patients compares to those observed in hospitalized patients with other viral pneumonias such as influenza is unknown. Objectives To assess the incidence of venous and arterial thrombotic complications in hospitalized patients with influenza as opposed to that observed in hospitalized patients with COVID‐19. Methods This was a retrospective cohort study; we used data from Statistics Netherlands (study period: 2018) on thrombotic complications in hospitalized patients with influenza. In parallel, we assessed the cumulative incidence of thrombotic complications—adjusted for competing risk of death—in patients with COVID‐19 in three Dutch hospitals (February 24 to April 26, 2020). Results Of the 13 217 hospitalized patients with influenza, 437 (3.3%) were diagnosed with thrombotic complications, versus 66 (11%) of the 579 hospitalized patients with COVID‐19. The 30‐day cumulative incidence of any thrombotic complication in influenza was 11% (95% confidence interval [CI], 9.4–12) versus 25% (95% CI, 18–32) in COVID‐19. For venous thrombotic (VTC) complications and arterial thrombotic complications alone, these numbers were, respectively, 3.6% (95% CI, 2.7–4.6) and 7.5% (95% CI, 6.3–8.8) in influenza versus 23% (95% CI, 16–29) and 4.4% (95% CI, 1.9–8.8) in COVID‐19. Conclusions The incidence of thrombotic complications in hospitalized patients with influenza was lower than in hospitalized patients with COVID‐19. This difference was mainly driven by a high risk of VTC complications in the patients with COVID‐19 admitted to the Intensive Care Unit. Remarkably, patients with influenza were more often diagnosed with arterial thrombotic complications. |
| first_indexed | 2024-03-12T05:39:50Z |
| format | Article |
| id | doaj.art-cd66aa34f5e5426e93e37e45c14001b7 |
| institution | Directory Open Access Journal |
| issn | 2475-0379 |
| language | English |
| last_indexed | 2024-03-12T05:39:50Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj.art-cd66aa34f5e5426e93e37e45c14001b72023-09-03T06:13:57ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792021-03-015341242010.1002/rth2.12496Risk of thrombotic complications in influenza versus COVID‐19 hospitalized patientsMilou A. M. Stals0Marco J. J. H. Grootenboers1Coen vanGuldener2Fleur H. J. Kaptein3Sander J. E. Braken4Qingui Chen5Gordon Chu6Erik M. vanDriel7Antonio Iglesias del Sol8Evert deJonge9K. Merijn Kant10Fleur Pals11Myrthe M. A. Toorop12Suzanne C. Cannegieter13Frederikus A. Klok14Menno V. Huisman15the Dutch COVID & Thrombosis Coalition (DCTC)Department of Thrombosis and Hemostasis Leiden University Medical Center Leiden The NetherlandsDepartment of Pulmonology Amphia Hospital Breda The NetherlandsDepartment of Internal Medicine Amphia Hospital Breda The NetherlandsDepartment of Thrombosis and Hemostasis Leiden University Medical Center Leiden The NetherlandsDepartment of Thrombosis and Hemostasis Leiden University Medical Center Leiden The NetherlandsDepartment of Clinical Epidemiology Leiden University Medical Center Leiden The NetherlandsDepartment of Thrombosis and Hemostasis Leiden University Medical Center Leiden The NetherlandsDepartment of Intensive Care Medicine Alrijne Hospital Leiderdorp The NetherlandsDepartment of Internal Medicine Alrijne Hospital Leiderdorp The NetherlandsDepartment of Intensive Care Medicine Leiden University Medical Center Leiden The NetherlandsDepartment of Intensive Care Medicine Amphia Hospital Breda The NetherlandsDepartment of Thrombosis and Hemostasis Leiden University Medical Center Leiden The NetherlandsDepartment of Clinical Epidemiology Leiden University Medical Center Leiden The NetherlandsDepartment of Thrombosis and Hemostasis Leiden University Medical Center Leiden The NetherlandsDepartment of Thrombosis and Hemostasis Leiden University Medical Center Leiden The NetherlandsDepartment of Thrombosis and Hemostasis Leiden University Medical Center Leiden The NetherlandsAbstract Background Whereas accumulating studies on patients with coronavirus disease 2019 (COVID‐19) report high incidences of thrombotic complications, large studies on clinically relevant thrombosis in patients with other respiratory tract infections are lacking. How this high risk in COVID‐19 patients compares to those observed in hospitalized patients with other viral pneumonias such as influenza is unknown. Objectives To assess the incidence of venous and arterial thrombotic complications in hospitalized patients with influenza as opposed to that observed in hospitalized patients with COVID‐19. Methods This was a retrospective cohort study; we used data from Statistics Netherlands (study period: 2018) on thrombotic complications in hospitalized patients with influenza. In parallel, we assessed the cumulative incidence of thrombotic complications—adjusted for competing risk of death—in patients with COVID‐19 in three Dutch hospitals (February 24 to April 26, 2020). Results Of the 13 217 hospitalized patients with influenza, 437 (3.3%) were diagnosed with thrombotic complications, versus 66 (11%) of the 579 hospitalized patients with COVID‐19. The 30‐day cumulative incidence of any thrombotic complication in influenza was 11% (95% confidence interval [CI], 9.4–12) versus 25% (95% CI, 18–32) in COVID‐19. For venous thrombotic (VTC) complications and arterial thrombotic complications alone, these numbers were, respectively, 3.6% (95% CI, 2.7–4.6) and 7.5% (95% CI, 6.3–8.8) in influenza versus 23% (95% CI, 16–29) and 4.4% (95% CI, 1.9–8.8) in COVID‐19. Conclusions The incidence of thrombotic complications in hospitalized patients with influenza was lower than in hospitalized patients with COVID‐19. This difference was mainly driven by a high risk of VTC complications in the patients with COVID‐19 admitted to the Intensive Care Unit. Remarkably, patients with influenza were more often diagnosed with arterial thrombotic complications.https://doi.org/10.1002/rth2.12496COVID‐19humanincidenceinfluenzapneumoniathrombosis |
| spellingShingle | Milou A. M. Stals Marco J. J. H. Grootenboers Coen vanGuldener Fleur H. J. Kaptein Sander J. E. Braken Qingui Chen Gordon Chu Erik M. vanDriel Antonio Iglesias del Sol Evert deJonge K. Merijn Kant Fleur Pals Myrthe M. A. Toorop Suzanne C. Cannegieter Frederikus A. Klok Menno V. Huisman the Dutch COVID & Thrombosis Coalition (DCTC) Risk of thrombotic complications in influenza versus COVID‐19 hospitalized patients Research and Practice in Thrombosis and Haemostasis COVID‐19 human incidence influenza pneumonia thrombosis |
| title | Risk of thrombotic complications in influenza versus COVID‐19 hospitalized patients |
| title_full | Risk of thrombotic complications in influenza versus COVID‐19 hospitalized patients |
| title_fullStr | Risk of thrombotic complications in influenza versus COVID‐19 hospitalized patients |
| title_full_unstemmed | Risk of thrombotic complications in influenza versus COVID‐19 hospitalized patients |
| title_short | Risk of thrombotic complications in influenza versus COVID‐19 hospitalized patients |
| title_sort | risk of thrombotic complications in influenza versus covid 19 hospitalized patients |
| topic | COVID‐19 human incidence influenza pneumonia thrombosis |
| url | https://doi.org/10.1002/rth2.12496 |
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