Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives
Peptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-acid monomer units) are oligomeric synthetic polymers that are becoming a valuable molecular tool in the biosciences. Of particular interest are their applications to the exploration of peptoid secondary structure...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/8/5282/ |
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| author | Rodney J. Ouellette Adrian S. Culf |
| author_facet | Rodney J. Ouellette Adrian S. Culf |
| author_sort | Rodney J. Ouellette |
| collection | DOAJ |
| description | Peptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-acid monomer units) are oligomeric synthetic polymers that are becoming a valuable molecular tool in the biosciences. Of particular interest are their applications to the exploration of peptoid secondary structures and drug design. Major advantages of peptoids as research and pharmaceutical tools include the ease and economy of synthesis, highly variable backbone and side-chain chemistry possibilities. At the same time, peptoids have been demonstrated as highly active in biological systems while resistant to proteolytic decay. This review with 227 references considers the solid-phase synthetic aspects of peptoid preparation and utilization up to 2010 from the instigation, by R. N. Zuckermann et al., of peptoid chemistry in 1992. |
| first_indexed | 2024-12-18T15:02:26Z |
| format | Article |
| id | doaj.art-cd6825126d6946c9b46d5276206a61b1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T15:02:26Z |
| publishDate | 2010-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cd6825126d6946c9b46d5276206a61b12022-12-21T21:03:51ZengMDPI AGMolecules1420-30492010-08-011585282533510.3390/molecules15085282Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and DerivativesRodney J. OuelletteAdrian S. CulfPeptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-acid monomer units) are oligomeric synthetic polymers that are becoming a valuable molecular tool in the biosciences. Of particular interest are their applications to the exploration of peptoid secondary structures and drug design. Major advantages of peptoids as research and pharmaceutical tools include the ease and economy of synthesis, highly variable backbone and side-chain chemistry possibilities. At the same time, peptoids have been demonstrated as highly active in biological systems while resistant to proteolytic decay. This review with 227 references considers the solid-phase synthetic aspects of peptoid preparation and utilization up to 2010 from the instigation, by R. N. Zuckermann et al., of peptoid chemistry in 1992.http://www.mdpi.com/1420-3049/15/8/5282/N-substituted polyglycine oligomerpeptoidsolid phase synthesissynthetic methods |
| spellingShingle | Rodney J. Ouellette Adrian S. Culf Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives Molecules N-substituted polyglycine oligomer peptoid solid phase synthesis synthetic methods |
| title | Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives |
| title_full | Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives |
| title_fullStr | Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives |
| title_full_unstemmed | Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives |
| title_short | Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α‑Peptoids) and Derivatives |
| title_sort | solid phase synthesis of n substituted glycine oligomers α peptoids and derivatives |
| topic | N-substituted polyglycine oligomer peptoid solid phase synthesis synthetic methods |
| url | http://www.mdpi.com/1420-3049/15/8/5282/ |
| work_keys_str_mv | AT rodneyjouellette solidphasesynthesisofnsubstitutedglycineoligomersapeptoidsandderivatives AT adriansculf solidphasesynthesisofnsubstitutedglycineoligomersapeptoidsandderivatives |