The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study
Abstract The negative relation of serum adiponectin to atherosclerosis becomes a positive association in patients with chronic kidney disease (CKD). We conducted a small-scale cross-sectional observational study, in 101 Japanese male hemodialysis patients, to examine the relationship of serum adipon...
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Nature Portfolio
2017-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-06850-4 |
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| author | Takeshi Sakura Senji Okuno Eriko Nishio Kyoko Norimine Eiji Ishimura Tomoyuki Yamakawa Shigeichi Shoji Masaaki Inaba |
| author_facet | Takeshi Sakura Senji Okuno Eriko Nishio Kyoko Norimine Eiji Ishimura Tomoyuki Yamakawa Shigeichi Shoji Masaaki Inaba |
| author_sort | Takeshi Sakura |
| collection | DOAJ |
| description | Abstract The negative relation of serum adiponectin to atherosclerosis becomes a positive association in patients with chronic kidney disease (CKD). We conducted a small-scale cross-sectional observational study, in 101 Japanese male hemodialysis patients, to examine the relationship of serum adiponectin and leptin to abdominal aortic calcification (AAC). The presence of AAC was evaluated from simple X-ray radiographs of the left lateral abdomen. Serum adiponectin was significantly higher in AAC-positive patients [18.8 (13.0–28.1) μg/mL] than in AAC-negative patients [15.4 (8.9–22.8) μg/mL] (p = 0.03), whereas serum leptin did not differ significantly between the two groups. Multiple logistic regression analysis showed that log adiponectin, but not log leptin, was independently and significantly associated in a positive manner with AAC (odds ratio: 16.31, 95% confidence interval: 1.70–156.41, p = 0.02), after adjustment for age, body weight, percentage body fat, hemodialysis duration, prevalence of diabetes mellitus, and other risk factors. In conclusion, we found a positive and independent association of serum adiponectin with AAC in male hemodialysis patients, indicating that the reversed association between serum adiponectin and atherosclerosis in patients with CKD dose not result from increased serum adiponectin due to the impaired urinary secretion. |
| first_indexed | 2024-12-17T10:22:03Z |
| format | Article |
| id | doaj.art-cd68d6212cd3415ab1004fee04a785e4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T10:22:03Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj.art-cd68d6212cd3415ab1004fee04a785e42022-12-21T21:52:46ZengNature PortfolioScientific Reports2045-23222017-07-01711610.1038/s41598-017-06850-4The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational studyTakeshi Sakura0Senji Okuno1Eriko Nishio2Kyoko Norimine3Eiji Ishimura4Tomoyuki Yamakawa5Shigeichi Shoji6Masaaki Inaba7Department of Metabolism, Endocrinology and Molecular Medicine, and Department of Nephrology, Osaka City University Graduate School of MedicineKidney Center, Shirasagi HospitalKidney Center, Shirasagi HospitalKidney Center, Shirasagi HospitalDepartment of Metabolism, Endocrinology and Molecular Medicine, and Department of Nephrology, Osaka City University Graduate School of MedicineKidney Center, Shirasagi HospitalKidney Center, Shirasagi HospitalDepartment of Metabolism, Endocrinology and Molecular Medicine, and Department of Nephrology, Osaka City University Graduate School of MedicineAbstract The negative relation of serum adiponectin to atherosclerosis becomes a positive association in patients with chronic kidney disease (CKD). We conducted a small-scale cross-sectional observational study, in 101 Japanese male hemodialysis patients, to examine the relationship of serum adiponectin and leptin to abdominal aortic calcification (AAC). The presence of AAC was evaluated from simple X-ray radiographs of the left lateral abdomen. Serum adiponectin was significantly higher in AAC-positive patients [18.8 (13.0–28.1) μg/mL] than in AAC-negative patients [15.4 (8.9–22.8) μg/mL] (p = 0.03), whereas serum leptin did not differ significantly between the two groups. Multiple logistic regression analysis showed that log adiponectin, but not log leptin, was independently and significantly associated in a positive manner with AAC (odds ratio: 16.31, 95% confidence interval: 1.70–156.41, p = 0.02), after adjustment for age, body weight, percentage body fat, hemodialysis duration, prevalence of diabetes mellitus, and other risk factors. In conclusion, we found a positive and independent association of serum adiponectin with AAC in male hemodialysis patients, indicating that the reversed association between serum adiponectin and atherosclerosis in patients with CKD dose not result from increased serum adiponectin due to the impaired urinary secretion.https://doi.org/10.1038/s41598-017-06850-4 |
| spellingShingle | Takeshi Sakura Senji Okuno Eriko Nishio Kyoko Norimine Eiji Ishimura Tomoyuki Yamakawa Shigeichi Shoji Masaaki Inaba The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study Scientific Reports |
| title | The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study |
| title_full | The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study |
| title_fullStr | The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study |
| title_full_unstemmed | The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study |
| title_short | The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study |
| title_sort | association of serum adiponectin with abdominal aortic calcification in japanese male hemodialysis patients a cross sectional observational study |
| url | https://doi.org/10.1038/s41598-017-06850-4 |
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