Brain Natriuretic Peptide (BNP) Affects Growth and Stress Tolerance of Representatives of the Human Microbiome, <i>Micrococcus luteus</i> C01 and <i>Alcaligenes faecalis</i> DOS7
Brain natriuretic peptide (BNP) is secreted by the ventricles of the heart during overload to signal heart failure. Slight bilateral skin itching induced by BNP has been associated with response activity of the skin microbiota. In this work, we studied the effect of 25–250,000 pg BNP/mL on the growt...
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MDPI AG
2022-06-01
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| author | Nataliya Loiko Oleg Kanunnikov Andrei Gannesen Vladislav Kovalenko Anastasia Vishnyakova Vladimir Axelrod Yuriy Litti |
| author_facet | Nataliya Loiko Oleg Kanunnikov Andrei Gannesen Vladislav Kovalenko Anastasia Vishnyakova Vladimir Axelrod Yuriy Litti |
| author_sort | Nataliya Loiko |
| collection | DOAJ |
| description | Brain natriuretic peptide (BNP) is secreted by the ventricles of the heart during overload to signal heart failure. Slight bilateral skin itching induced by BNP has been associated with response activity of the skin microbiota. In this work, we studied the effect of 25–250,000 pg BNP/mL on the growth, long-term survival, and stress (H<sub>2</sub>O<sub>2</sub>, antibiotics, salinity, heat and pH shock) resistance of human symbiont bacteria: Gram-positive <i>Micrococcus luteus</i> C01 and Gram-negative <i>Alcaligenes faecalis</i> DOS7. The effect of BNP turned out to be dose-dependent. Up to 250 pg BNP/mL made bacteria more stress resistant. At 2500 pg BNP/mL (heart failure) the thermosensitivity of the bacteria increased. Almost all considered BNP concentrations increased the resistance of bacteria to the action of tetracycline and ciprofloxacin. Both bacteria survived 1.3–1.7 times better during long-term (up to 4 months) storage. Our findings are important both for clinical medical practice and for practical application in other areas. For example, BNP can be used to obtain stress-resistant bacteria, which is important in the collection of microorganisms, as well as for the production of bacterial preparations and probiotics for cosmetology, agriculture, and waste management. |
| first_indexed | 2024-03-09T03:41:52Z |
| format | Article |
| id | doaj.art-cd68ec362dd04acaae4f4971dc323ffc |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T03:41:52Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-cd68ec362dd04acaae4f4971dc323ffc2023-12-03T14:40:25ZengMDPI AGBiology2079-77372022-06-0111798410.3390/biology11070984Brain Natriuretic Peptide (BNP) Affects Growth and Stress Tolerance of Representatives of the Human Microbiome, <i>Micrococcus luteus</i> C01 and <i>Alcaligenes faecalis</i> DOS7Nataliya Loiko0Oleg Kanunnikov1Andrei Gannesen2Vladislav Kovalenko3Anastasia Vishnyakova4Vladimir Axelrod5Yuriy Litti6Winogradsky Institute of Microbiology, “Fundamentals of Biotechnology” Federal Research Center, Russian Academy of Sciences, 117312 Moscow, RussiaRail Chemical LLC, 105005 Moscow, RussiaWinogradsky Institute of Microbiology, “Fundamentals of Biotechnology” Federal Research Center, Russian Academy of Sciences, 117312 Moscow, RussiaSemenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, 119991 Moscow, RussiaWinogradsky Institute of Microbiology, “Fundamentals of Biotechnology” Federal Research Center, Russian Academy of Sciences, 117312 Moscow, RussiaRail Chemical LLC, 105005 Moscow, RussiaWinogradsky Institute of Microbiology, “Fundamentals of Biotechnology” Federal Research Center, Russian Academy of Sciences, 117312 Moscow, RussiaBrain natriuretic peptide (BNP) is secreted by the ventricles of the heart during overload to signal heart failure. Slight bilateral skin itching induced by BNP has been associated with response activity of the skin microbiota. In this work, we studied the effect of 25–250,000 pg BNP/mL on the growth, long-term survival, and stress (H<sub>2</sub>O<sub>2</sub>, antibiotics, salinity, heat and pH shock) resistance of human symbiont bacteria: Gram-positive <i>Micrococcus luteus</i> C01 and Gram-negative <i>Alcaligenes faecalis</i> DOS7. The effect of BNP turned out to be dose-dependent. Up to 250 pg BNP/mL made bacteria more stress resistant. At 2500 pg BNP/mL (heart failure) the thermosensitivity of the bacteria increased. Almost all considered BNP concentrations increased the resistance of bacteria to the action of tetracycline and ciprofloxacin. Both bacteria survived 1.3–1.7 times better during long-term (up to 4 months) storage. Our findings are important both for clinical medical practice and for practical application in other areas. For example, BNP can be used to obtain stress-resistant bacteria, which is important in the collection of microorganisms, as well as for the production of bacterial preparations and probiotics for cosmetology, agriculture, and waste management.https://www.mdpi.com/2079-7737/11/7/984brain natriuretic peptide (BNP)<i>Micrococcus luteus</i><i>Alcaligenes faecalis</i>stress resistanceosmotic stressacid and base stress |
| spellingShingle | Nataliya Loiko Oleg Kanunnikov Andrei Gannesen Vladislav Kovalenko Anastasia Vishnyakova Vladimir Axelrod Yuriy Litti Brain Natriuretic Peptide (BNP) Affects Growth and Stress Tolerance of Representatives of the Human Microbiome, <i>Micrococcus luteus</i> C01 and <i>Alcaligenes faecalis</i> DOS7 Biology brain natriuretic peptide (BNP) <i>Micrococcus luteus</i> <i>Alcaligenes faecalis</i> stress resistance osmotic stress acid and base stress |
| title | Brain Natriuretic Peptide (BNP) Affects Growth and Stress Tolerance of Representatives of the Human Microbiome, <i>Micrococcus luteus</i> C01 and <i>Alcaligenes faecalis</i> DOS7 |
| title_full | Brain Natriuretic Peptide (BNP) Affects Growth and Stress Tolerance of Representatives of the Human Microbiome, <i>Micrococcus luteus</i> C01 and <i>Alcaligenes faecalis</i> DOS7 |
| title_fullStr | Brain Natriuretic Peptide (BNP) Affects Growth and Stress Tolerance of Representatives of the Human Microbiome, <i>Micrococcus luteus</i> C01 and <i>Alcaligenes faecalis</i> DOS7 |
| title_full_unstemmed | Brain Natriuretic Peptide (BNP) Affects Growth and Stress Tolerance of Representatives of the Human Microbiome, <i>Micrococcus luteus</i> C01 and <i>Alcaligenes faecalis</i> DOS7 |
| title_short | Brain Natriuretic Peptide (BNP) Affects Growth and Stress Tolerance of Representatives of the Human Microbiome, <i>Micrococcus luteus</i> C01 and <i>Alcaligenes faecalis</i> DOS7 |
| title_sort | brain natriuretic peptide bnp affects growth and stress tolerance of representatives of the human microbiome i micrococcus luteus i c01 and i alcaligenes faecalis i dos7 |
| topic | brain natriuretic peptide (BNP) <i>Micrococcus luteus</i> <i>Alcaligenes faecalis</i> stress resistance osmotic stress acid and base stress |
| url | https://www.mdpi.com/2079-7737/11/7/984 |
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