Polyamine Depletion Strategies in Cancer: Remodeling the Tumor Immune Microenvironment to Enhance Anti-Tumor Responses

Polyamine Depletion Strategies in Cancer: Remodeling the Tumor Immune Microenvironment to Enhance Anti-Tumor Responses

Polyamine biosynthesis is frequently dysregulated in cancers, and enhanced flux increases intracellular polyamines necessary for promoting cell growth, proliferation, and function. Polyamine depletion strategies demonstrate efficacy in reducing tumor growth and increasing survival in animal models o...

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Bibliographic Details
Main Authors:	Alexander Chin, Charles J. Bieberich, Tracy Murray Stewart, Robert A. Casero
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Medical Sciences
Subjects:	polyamines tumor microenvironment cancer therapeutic immune regulation difluoromethylornithine polyamine blocking therapy
Online Access:	https://www.mdpi.com/2076-3271/10/2/31

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