L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness

L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness

Abstract Background Metastasis is the predominant cause for cancer morbidity and mortality accounting for approximatively 90% of cancer deaths. The actin-bundling protein L-plastin has been proposed as a metastatic marker and phosphorylation on its residue Ser5 is known to increase its actin-bundlin...

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Bibliographic Details
Main Authors: Raquel A. C. Machado, Dunja Stojevski, Sébastien De Landtsheer, Philippe Lucarelli, Alexandre Baron, Thomas Sauter, Elisabeth Schaffner-Reckinger
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Cell Communication and Signaling
Subjects:
L-plastin
Actin-bundling
PI3K pathway
ERK/MAPK pathway
SGK
RSK
Online Access:https://doi.org/10.1186/s12964-021-00710-5

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