Bacteriophage P22 Capsid as a Pluripotent Nanotechnology Tool
The <i>Salmonella enterica</i> bacteriophage P22 is one of the most promising models for the development of virus-like particle (VLP) nanocages. It possesses an icosahedral T = 7 capsid, assembled by the combination of two structural proteins: the coat protein (gp5) and the scaffold prot...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/2/516 |
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| author | Victor Alejandro Essus Getúlio Silva e Souza Júnior Gabriel Henrique Pereira Nunes Juliana dos Santos Oliveira Bruna Mafra de Faria Luciana Ferreira Romão Juliana Reis Cortines |
| author_facet | Victor Alejandro Essus Getúlio Silva e Souza Júnior Gabriel Henrique Pereira Nunes Juliana dos Santos Oliveira Bruna Mafra de Faria Luciana Ferreira Romão Juliana Reis Cortines |
| author_sort | Victor Alejandro Essus |
| collection | DOAJ |
| description | The <i>Salmonella enterica</i> bacteriophage P22 is one of the most promising models for the development of virus-like particle (VLP) nanocages. It possesses an icosahedral T = 7 capsid, assembled by the combination of two structural proteins: the coat protein (gp5) and the scaffold protein (gp8). The P22 capsid has the remarkable capability of undergoing structural transition into three morphologies with differing diameters and wall-pore sizes. These varied morphologies can be explored for the design of nanoplatforms, such as for the development of cargo internalization strategies. The capsid proteic nature allows for the extensive modification of its structure, enabling the addition of non-native structures to alter the VLP properties or confer them to diverse ends. Various molecules were added to the P22 VLP through genetic, chemical, and other means to both the capsid and the scaffold protein, permitting the encapsulation or the presentation of cargo. This allows the particle to be exploited for numerous purposes—for example, as a nanocarrier, nanoreactor, and vaccine model, among other applications. Therefore, the present review intends to give an overview of the literature on this amazing particle. |
| first_indexed | 2024-03-11T08:01:06Z |
| format | Article |
| id | doaj.art-cd69f56363844a51b1b24789a4aa83a4 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T08:01:06Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-cd69f56363844a51b1b24789a4aa83a42023-11-16T23:50:05ZengMDPI AGViruses1999-49152023-02-0115251610.3390/v15020516Bacteriophage P22 Capsid as a Pluripotent Nanotechnology ToolVictor Alejandro Essus0Getúlio Silva e Souza Júnior1Gabriel Henrique Pereira Nunes2Juliana dos Santos Oliveira3Bruna Mafra de Faria4Luciana Ferreira Romão5Juliana Reis Cortines6Laboratório de Virologia e Espectrometria de Massas (LAVEM), Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21590-902, BrazilLaboratório de Virologia e Espectrometria de Massas (LAVEM), Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21590-902, BrazilLaboratório de Virologia e Espectrometria de Massas (LAVEM), Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21590-902, BrazilLaboratório de Virologia e Espectrometria de Massas (LAVEM), Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21590-902, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, CCS, Bl. F026, Rio de Janeiro 21941-590, BrazilInstituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373, CCS, Bl. F026, Rio de Janeiro 21941-590, BrazilLaboratório de Virologia e Espectrometria de Massas (LAVEM), Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21590-902, BrazilThe <i>Salmonella enterica</i> bacteriophage P22 is one of the most promising models for the development of virus-like particle (VLP) nanocages. It possesses an icosahedral T = 7 capsid, assembled by the combination of two structural proteins: the coat protein (gp5) and the scaffold protein (gp8). The P22 capsid has the remarkable capability of undergoing structural transition into three morphologies with differing diameters and wall-pore sizes. These varied morphologies can be explored for the design of nanoplatforms, such as for the development of cargo internalization strategies. The capsid proteic nature allows for the extensive modification of its structure, enabling the addition of non-native structures to alter the VLP properties or confer them to diverse ends. Various molecules were added to the P22 VLP through genetic, chemical, and other means to both the capsid and the scaffold protein, permitting the encapsulation or the presentation of cargo. This allows the particle to be exploited for numerous purposes—for example, as a nanocarrier, nanoreactor, and vaccine model, among other applications. Therefore, the present review intends to give an overview of the literature on this amazing particle.https://www.mdpi.com/1999-4915/15/2/516bacteriophage P22virus-like particlesnanoparticleprotein cagenanotechnology |
| spellingShingle | Victor Alejandro Essus Getúlio Silva e Souza Júnior Gabriel Henrique Pereira Nunes Juliana dos Santos Oliveira Bruna Mafra de Faria Luciana Ferreira Romão Juliana Reis Cortines Bacteriophage P22 Capsid as a Pluripotent Nanotechnology Tool Viruses bacteriophage P22 virus-like particles nanoparticle protein cage nanotechnology |
| title | Bacteriophage P22 Capsid as a Pluripotent Nanotechnology Tool |
| title_full | Bacteriophage P22 Capsid as a Pluripotent Nanotechnology Tool |
| title_fullStr | Bacteriophage P22 Capsid as a Pluripotent Nanotechnology Tool |
| title_full_unstemmed | Bacteriophage P22 Capsid as a Pluripotent Nanotechnology Tool |
| title_short | Bacteriophage P22 Capsid as a Pluripotent Nanotechnology Tool |
| title_sort | bacteriophage p22 capsid as a pluripotent nanotechnology tool |
| topic | bacteriophage P22 virus-like particles nanoparticle protein cage nanotechnology |
| url | https://www.mdpi.com/1999-4915/15/2/516 |
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