Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models

Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models

Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in people with Down syndrome (DS, trisomy 21). Because of the limited availability of human post-mortem tissue, DS mouse models are of great interest to study these changes and the underlying neurobiolog...

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Bibliographic Details
Main Authors: Alain D. Dekker, Yannick Vermeiren, Christelle Albac, Eva Lana-Elola, Sheona Watson-Scales, Dorota Gibbins, Tony Aerts, Debby Van Dam, Elizabeth M.C. Fisher, Victor L.J. Tybulewicz, Marie-Claude Potier, Peter P. De Deyn
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Neurobiology of Disease
Subjects:
Aging
Dopamine
Down syndrome
Dp1Tyb
Monoamines
Mouse models
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301341

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