A case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteries
Uterine arteriovenous malformation (AVM) is a potentially life-threatening condition characterized by abrupt and profuse uterine bleeding from abnormal connections between arteries and veins in the myometrium. It is commonly associated with prior pregnancy or uterine trauma. We present a case of sev...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-11-01
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| Series: | Gynecology and Minimally Invasive Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213307015001446 |
| _version_ | 1811308338909020160 |
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| author | Hiroyuki Yazawa Syu Soeda Tsuyoshi Hiraiwa Masayo Takaiwa Keiya Fujimori |
| author_facet | Hiroyuki Yazawa Syu Soeda Tsuyoshi Hiraiwa Masayo Takaiwa Keiya Fujimori |
| author_sort | Hiroyuki Yazawa |
| collection | DOAJ |
| description | Uterine arteriovenous malformation (AVM) is a potentially life-threatening condition characterized by abrupt and profuse uterine bleeding from abnormal connections between arteries and veins in the myometrium. It is commonly associated with prior pregnancy or uterine trauma. We present a case of severe uterine AVM treated with danazol and transarterial embolization (TAE). A 38-year-old patient with a history of two abortions and a myomectomy was referred to our hospital for intermittent massive uterine bleeding. She was diagnosed with uterine AVM by transvaginal color Doppler ultrasonography and helical computed tomography (CT). Diagnostic three-dimensional CT (3D-CT) angiography clearly demonstrated hypervascular tangles of uterine vessels, feeding arteries, remarkably dilated draining veins, as well as early filling of the internal iliac vein and the inferior vena cava, indicating massive arteriovenous shunting in the uterus. Danazol was administrated for 10 months to reduce the shunting of the uterine AVM before TAE with N-butyl-cyanoacrylate of the left ovarian artery and left uterine artery was successfully performed. After the procedure, we confirmed that shunting through the uterine AVM was markedly reduced. The patient has not experienced any severe uterine bleeding since the treatment. |
| first_indexed | 2024-04-13T09:21:27Z |
| format | Article |
| id | doaj.art-cd6e18cdfd9b41029cf2fa630be5d02d |
| institution | Directory Open Access Journal |
| issn | 2213-3070 |
| language | English |
| last_indexed | 2024-04-13T09:21:27Z |
| publishDate | 2015-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Gynecology and Minimally Invasive Therapy |
| spelling | doaj.art-cd6e18cdfd9b41029cf2fa630be5d02d2022-12-22T02:52:36ZengWolters Kluwer Medknow PublicationsGynecology and Minimally Invasive Therapy2213-30702015-11-014414915310.1016/j.gmit.2015.10.001A case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteriesHiroyuki Yazawa0Syu Soeda1Tsuyoshi Hiraiwa2Masayo Takaiwa3Keiya Fujimori4Department of Obstetrics and Gynecology, Fukushima Red Cross Hospital, Fukushima, JapanDepartment of Obstetrics and Gynecology, Fukushima Medical University, School of Medicine, Fukushima, JapanDepartment of Obstetrics and Gynecology, Fukushima Red Cross Hospital, Fukushima, JapanDepartment of Obstetrics and Gynecology, Fukushima Red Cross Hospital, Fukushima, JapanDepartment of Obstetrics and Gynecology, Fukushima Medical University, School of Medicine, Fukushima, JapanUterine arteriovenous malformation (AVM) is a potentially life-threatening condition characterized by abrupt and profuse uterine bleeding from abnormal connections between arteries and veins in the myometrium. It is commonly associated with prior pregnancy or uterine trauma. We present a case of severe uterine AVM treated with danazol and transarterial embolization (TAE). A 38-year-old patient with a history of two abortions and a myomectomy was referred to our hospital for intermittent massive uterine bleeding. She was diagnosed with uterine AVM by transvaginal color Doppler ultrasonography and helical computed tomography (CT). Diagnostic three-dimensional CT (3D-CT) angiography clearly demonstrated hypervascular tangles of uterine vessels, feeding arteries, remarkably dilated draining veins, as well as early filling of the internal iliac vein and the inferior vena cava, indicating massive arteriovenous shunting in the uterus. Danazol was administrated for 10 months to reduce the shunting of the uterine AVM before TAE with N-butyl-cyanoacrylate of the left ovarian artery and left uterine artery was successfully performed. After the procedure, we confirmed that shunting through the uterine AVM was markedly reduced. The patient has not experienced any severe uterine bleeding since the treatment.http://www.sciencedirect.com/science/article/pii/S22133070150014463D-CT angiographycolor Doppler ultrasonographydanazoltransarterial embolizationuterine arteriovenous malformation |
| spellingShingle | Hiroyuki Yazawa Syu Soeda Tsuyoshi Hiraiwa Masayo Takaiwa Keiya Fujimori A case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteries Gynecology and Minimally Invasive Therapy 3D-CT angiography color Doppler ultrasonography danazol transarterial embolization uterine arteriovenous malformation |
| title | A case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteries |
| title_full | A case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteries |
| title_fullStr | A case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteries |
| title_full_unstemmed | A case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteries |
| title_short | A case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteries |
| title_sort | case of severe uterine arteriovenous malformation treated with danazol followed by a transarterial embolization of unilateral uterine and ovarian arteries |
| topic | 3D-CT angiography color Doppler ultrasonography danazol transarterial embolization uterine arteriovenous malformation |
| url | http://www.sciencedirect.com/science/article/pii/S2213307015001446 |
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