Characteristics of HCV infection in oncohematological patients
Objective: clinical and laboratory characteristics of HCV infection in patients with oncohematological malignancies. Materials and Methods: The study included 106 patients with a positive serum HCV antibody (anti-HCV) test result, who were examined or treated in 5 specialized oncohematological units...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2020-03-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/1018 |
| _version_ | 1797695248573399040 |
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| author | D. A. Lioznov M. S. Nozhkin O. V. Gorchakova T. V. Antonova |
| author_facet | D. A. Lioznov M. S. Nozhkin O. V. Gorchakova T. V. Antonova |
| author_sort | D. A. Lioznov |
| collection | DOAJ |
| description | Objective: clinical and laboratory characteristics of HCV infection in patients with oncohematological malignancies. Materials and Methods: The study included 106 patients with a positive serum HCV antibody (anti-HCV) test result, who were examined or treated in 5 specialized oncohematological units of different hospitals in Saint Petersburg in 2018–2019.Laboratory tests included: ALT and AST activity, qualitative (with sensitivity of 60 IU/ml) and quantitative determination of HCV RNA, as well as HCV genotyping by real-time PCR. The presence and the grade of liver fibrosis according to the METAVIR scale were evaluated by indirect elastography on Fibroscan. Results: Men were predominant (62,2%), and most of patients (67%) were of young and middle age (18-59 years old). HCV infection was confirmed in 68% patients, and in 41.7% of them HCV genotype 3 was detected. HCV RNA was not detected in 32% cases, suggesting the spontaneous clearance of the virus. Severe liver fibrosis (F3) or cirrhosis (F4) were found in 40% patients with confirmed viremia. In most patients, the normal ALT activity level was registered. 86% patients diagnosed with HCV infection were followed up by an infectious disease specialist until the present study. 19% patients received antiviral therapy for HCV infection. Conclusion: A significant proportion of patients with advanced liver fibrosis and HCV 3 genotype, causing the greatest difficulties in antiviral treatment for HCV infection, was revealed. Prescription of direct-acting antiviral agents in the early terms after establishment of the diagnosis is reasonable. |
| first_indexed | 2024-03-12T03:09:39Z |
| format | Article |
| id | doaj.art-cd71265990084087a4cc1577f619d8f0 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T03:09:39Z |
| publishDate | 2020-03-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-cd71265990084087a4cc1577f619d8f02023-09-03T14:29:58ZrusJournal InfectologyЖурнал инфектологии2072-67322020-03-01121919510.22625/2072-6732-2020-12-1-91-95792Characteristics of HCV infection in oncohematological patientsD. A. Lioznov0M. S. Nozhkin1O. V. Gorchakova2T. V. Antonova3Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова; Научно-исследовательский институт гриппа имени А.А. СмородинцеваПервый Санкт-Петербургский государственный медицинский университет им. академика И.П. ПавловаПервый Санкт-Петербургский государственный медицинский университет им. академика И.П. ПавловаПервый Санкт-Петербургский государственный медицинский университет им. академика И.П. ПавловаObjective: clinical and laboratory characteristics of HCV infection in patients with oncohematological malignancies. Materials and Methods: The study included 106 patients with a positive serum HCV antibody (anti-HCV) test result, who were examined or treated in 5 specialized oncohematological units of different hospitals in Saint Petersburg in 2018–2019.Laboratory tests included: ALT and AST activity, qualitative (with sensitivity of 60 IU/ml) and quantitative determination of HCV RNA, as well as HCV genotyping by real-time PCR. The presence and the grade of liver fibrosis according to the METAVIR scale were evaluated by indirect elastography on Fibroscan. Results: Men were predominant (62,2%), and most of patients (67%) were of young and middle age (18-59 years old). HCV infection was confirmed in 68% patients, and in 41.7% of them HCV genotype 3 was detected. HCV RNA was not detected in 32% cases, suggesting the spontaneous clearance of the virus. Severe liver fibrosis (F3) or cirrhosis (F4) were found in 40% patients with confirmed viremia. In most patients, the normal ALT activity level was registered. 86% patients diagnosed with HCV infection were followed up by an infectious disease specialist until the present study. 19% patients received antiviral therapy for HCV infection. Conclusion: A significant proportion of patients with advanced liver fibrosis and HCV 3 genotype, causing the greatest difficulties in antiviral treatment for HCV infection, was revealed. Prescription of direct-acting antiviral agents in the early terms after establishment of the diagnosis is reasonable.https://journal.niidi.ru/jofin/article/view/1018хронический гепатит с, онкогематологические заболевания, диспансерное наблюдение |
| spellingShingle | D. A. Lioznov M. S. Nozhkin O. V. Gorchakova T. V. Antonova Characteristics of HCV infection in oncohematological patients Журнал инфектологии хронический гепатит с, онкогематологические заболевания, диспансерное наблюдение |
| title | Characteristics of HCV infection in oncohematological patients |
| title_full | Characteristics of HCV infection in oncohematological patients |
| title_fullStr | Characteristics of HCV infection in oncohematological patients |
| title_full_unstemmed | Characteristics of HCV infection in oncohematological patients |
| title_short | Characteristics of HCV infection in oncohematological patients |
| title_sort | characteristics of hcv infection in oncohematological patients |
| topic | хронический гепатит с, онкогематологические заболевания, диспансерное наблюдение |
| url | https://journal.niidi.ru/jofin/article/view/1018 |
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