A stereological study of synapse number in the epileptic human hippocampus
Hippocampal sclerosis is the most frequent pathology encountered in resected mesial temporal structures from patients with intractable temporal lobe epilepsy (TLE). Here, we have used stereological methods to compare the overall density of synapses and neurons between non-sclerotic and sclerotic hip...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-02-01
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| Series: | Frontiers in Neuroanatomy |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00008/full |
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| author | Lidia eAlonso-Nanclares Lidia eAlonso-Nanclares Lidia eAlonso-Nanclares Asta eKastanauskaite Asta eKastanauskaite Asta eKastanauskaite José-Rodrigo eRodriguez José-Rodrigo eRodriguez José-Rodrigo eRodriguez Juncal eGonzalez-Soriano Javier eDeFelipe Javier eDeFelipe Javier eDeFelipe |
| author_facet | Lidia eAlonso-Nanclares Lidia eAlonso-Nanclares Lidia eAlonso-Nanclares Asta eKastanauskaite Asta eKastanauskaite Asta eKastanauskaite José-Rodrigo eRodriguez José-Rodrigo eRodriguez José-Rodrigo eRodriguez Juncal eGonzalez-Soriano Javier eDeFelipe Javier eDeFelipe Javier eDeFelipe |
| author_sort | Lidia eAlonso-Nanclares |
| collection | DOAJ |
| description | Hippocampal sclerosis is the most frequent pathology encountered in resected mesial temporal structures from patients with intractable temporal lobe epilepsy (TLE). Here, we have used stereological methods to compare the overall density of synapses and neurons between non-sclerotic and sclerotic hippocampal tissue obtained by surgical resection from patients with TLE. Specifically, we examined the possible changes in the subiculum and CA1, regions that seem to be critical for the development and/or maintenance of seizures in these patients. We found a remarkable decrease in synaptic and neuronal density in the sclerotic CA1, and while the subiculum from the sclerotic hippocampus did not display changes in synaptic density, the neuronal density was higher. Since the subiculum from the sclerotic hippocampus displays a significant increase in neuronal density, as well as a various other neurochemical changes, we propose that the apparently normal subiculum from the sclerotic hippocampus suffers profound alterations in neuronal circuits at both the molecular and synaptic level that are likely to be critical for the development or maintenance of seizure activity. |
| first_indexed | 2024-04-12T14:01:25Z |
| format | Article |
| id | doaj.art-cd71f57a1b784569bbb8eb50bd1c35c6 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-04-12T14:01:25Z |
| publishDate | 2011-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-cd71f57a1b784569bbb8eb50bd1c35c62022-12-22T03:30:13ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292011-02-01510.3389/fnana.2011.000089063A stereological study of synapse number in the epileptic human hippocampusLidia eAlonso-Nanclares0Lidia eAlonso-Nanclares1Lidia eAlonso-Nanclares2Asta eKastanauskaite3Asta eKastanauskaite4Asta eKastanauskaite5José-Rodrigo eRodriguez6José-Rodrigo eRodriguez7José-Rodrigo eRodriguez8Juncal eGonzalez-Soriano9Javier eDeFelipe10Javier eDeFelipe11Javier eDeFelipe12Instituto Cajal (CSIC)Universidad Politécnica de MadridCentro Investigación Biomédica Red Enf. NeurodegenInstituto Cajal (CSIC)Universidad Politécnica de MadridCentro Investigación Biomédica Red Enf. NeurodegenInstituto Cajal (CSIC)Universidad Politécnica de MadridCentro Investigación Biomédica Red Enf. NeurodegenVeterinary Faculty, Universidad Complutense of MadridInstituto Cajal (CSIC)Universidad Politécnica de MadridCentro Investigación Biomédica Red Enf. NeurodegenHippocampal sclerosis is the most frequent pathology encountered in resected mesial temporal structures from patients with intractable temporal lobe epilepsy (TLE). Here, we have used stereological methods to compare the overall density of synapses and neurons between non-sclerotic and sclerotic hippocampal tissue obtained by surgical resection from patients with TLE. Specifically, we examined the possible changes in the subiculum and CA1, regions that seem to be critical for the development and/or maintenance of seizures in these patients. We found a remarkable decrease in synaptic and neuronal density in the sclerotic CA1, and while the subiculum from the sclerotic hippocampus did not display changes in synaptic density, the neuronal density was higher. Since the subiculum from the sclerotic hippocampus displays a significant increase in neuronal density, as well as a various other neurochemical changes, we propose that the apparently normal subiculum from the sclerotic hippocampus suffers profound alterations in neuronal circuits at both the molecular and synaptic level that are likely to be critical for the development or maintenance of seizure activity.http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00008/fullGliosisSynapsesElectron microscopyHippocampal SclerosisTemporal Lobe Epilepsy |
| spellingShingle | Lidia eAlonso-Nanclares Lidia eAlonso-Nanclares Lidia eAlonso-Nanclares Asta eKastanauskaite Asta eKastanauskaite Asta eKastanauskaite José-Rodrigo eRodriguez José-Rodrigo eRodriguez José-Rodrigo eRodriguez Juncal eGonzalez-Soriano Javier eDeFelipe Javier eDeFelipe Javier eDeFelipe A stereological study of synapse number in the epileptic human hippocampus Frontiers in Neuroanatomy Gliosis Synapses Electron microscopy Hippocampal Sclerosis Temporal Lobe Epilepsy |
| title | A stereological study of synapse number in the epileptic human hippocampus |
| title_full | A stereological study of synapse number in the epileptic human hippocampus |
| title_fullStr | A stereological study of synapse number in the epileptic human hippocampus |
| title_full_unstemmed | A stereological study of synapse number in the epileptic human hippocampus |
| title_short | A stereological study of synapse number in the epileptic human hippocampus |
| title_sort | stereological study of synapse number in the epileptic human hippocampus |
| topic | Gliosis Synapses Electron microscopy Hippocampal Sclerosis Temporal Lobe Epilepsy |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2011.00008/full |
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