Additional primary malignancies in a Polish cohort of uveal melanoma patients: a review of 644 patients with long-term follow-up
Abstract Aim To investigate the frequency and location of additional primary malignancies in a Polish cohort of uveal melanoma (UM) patients registered in a single centre database. Material and method Retrospective data analysis of patients treated for uveal melanoma at the Department of Ophthalmolo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-023-03246-z |
| _version_ | 1797388504185962496 |
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| author | Marta Wróblewska-Zierhoffer Barbara Paprzycka Anna Kubiak Łukasz Tomczyk Iwona Rospond-Kubiak |
| author_facet | Marta Wróblewska-Zierhoffer Barbara Paprzycka Anna Kubiak Łukasz Tomczyk Iwona Rospond-Kubiak |
| author_sort | Marta Wróblewska-Zierhoffer |
| collection | DOAJ |
| description | Abstract Aim To investigate the frequency and location of additional primary malignancies in a Polish cohort of uveal melanoma (UM) patients registered in a single centre database. Material and method Retrospective data analysis of patients treated for uveal melanoma at the Department of Ophthalmology, Poznań University of Medical Sciences, Poland between 1991 and 2017. Data on the diagnosis of the additional malignancies were obtained during the follow-up visits in our Department and/or from the Greater Poland Cancer Registry. The exclusion criteria comprised no confirmed follow-up or incomplete clinical entry data. Results Among 644 UM patients registered in the database up to 2017, the additional malignancy was diagnosed in 126 (20%) patients: 71 men, 55 women at the median age of 67 years (range: 34–94). In 48 patients (38%), the additional malignancy occurred prior to the diagnosis of UM, in 73 (58%) patients - after it. The most common locations of second cancer were skin (20 cases / 15%), breast (17 cases / 13%) and lungs (15 cases / 12%). The median follow-up was 36 months (range: 3–242). 87 patients (69%) died by the study close, 32 (37%) of them due to metastatic disease from uveal melanoma, 41 (47%) due to another cancer. Conclusions The frequency of additional primary malignancies was higher in our cohort than reported by most of other groups. If there is a certain predisposition to a specific type of additional primary carcinoma in UM patients, the analysis of larger database is required. |
| first_indexed | 2024-03-08T22:40:46Z |
| format | Article |
| id | doaj.art-cd72013c18304810a9364e2ab0ad2e84 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-08T22:40:46Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-cd72013c18304810a9364e2ab0ad2e842023-12-17T12:10:31ZengBMCBMC Ophthalmology1471-24152023-12-012311810.1186/s12886-023-03246-zAdditional primary malignancies in a Polish cohort of uveal melanoma patients: a review of 644 patients with long-term follow-upMarta Wróblewska-Zierhoffer0Barbara Paprzycka1Anna Kubiak2Łukasz Tomczyk3Iwona Rospond-Kubiak4Department of Ophthalmology, Poznań University of Medical SciencesDepartment of Ophthalmology, Poznań District HospitalGreater Poland Cancer Registry, Greater Poland Cancer CentreDepartment of Food Safety and Quality Management, Poznań University of Life SciencesDepartment of Ophthalmology, Poznań University of Medical SciencesAbstract Aim To investigate the frequency and location of additional primary malignancies in a Polish cohort of uveal melanoma (UM) patients registered in a single centre database. Material and method Retrospective data analysis of patients treated for uveal melanoma at the Department of Ophthalmology, Poznań University of Medical Sciences, Poland between 1991 and 2017. Data on the diagnosis of the additional malignancies were obtained during the follow-up visits in our Department and/or from the Greater Poland Cancer Registry. The exclusion criteria comprised no confirmed follow-up or incomplete clinical entry data. Results Among 644 UM patients registered in the database up to 2017, the additional malignancy was diagnosed in 126 (20%) patients: 71 men, 55 women at the median age of 67 years (range: 34–94). In 48 patients (38%), the additional malignancy occurred prior to the diagnosis of UM, in 73 (58%) patients - after it. The most common locations of second cancer were skin (20 cases / 15%), breast (17 cases / 13%) and lungs (15 cases / 12%). The median follow-up was 36 months (range: 3–242). 87 patients (69%) died by the study close, 32 (37%) of them due to metastatic disease from uveal melanoma, 41 (47%) due to another cancer. Conclusions The frequency of additional primary malignancies was higher in our cohort than reported by most of other groups. If there is a certain predisposition to a specific type of additional primary carcinoma in UM patients, the analysis of larger database is required.https://doi.org/10.1186/s12886-023-03246-zEyeMalignant NeoplasmUveal MelanomaSecond primary carcinoma |
| spellingShingle | Marta Wróblewska-Zierhoffer Barbara Paprzycka Anna Kubiak Łukasz Tomczyk Iwona Rospond-Kubiak Additional primary malignancies in a Polish cohort of uveal melanoma patients: a review of 644 patients with long-term follow-up BMC Ophthalmology Eye Malignant Neoplasm Uveal Melanoma Second primary carcinoma |
| title | Additional primary malignancies in a Polish cohort of uveal melanoma patients: a review of 644 patients with long-term follow-up |
| title_full | Additional primary malignancies in a Polish cohort of uveal melanoma patients: a review of 644 patients with long-term follow-up |
| title_fullStr | Additional primary malignancies in a Polish cohort of uveal melanoma patients: a review of 644 patients with long-term follow-up |
| title_full_unstemmed | Additional primary malignancies in a Polish cohort of uveal melanoma patients: a review of 644 patients with long-term follow-up |
| title_short | Additional primary malignancies in a Polish cohort of uveal melanoma patients: a review of 644 patients with long-term follow-up |
| title_sort | additional primary malignancies in a polish cohort of uveal melanoma patients a review of 644 patients with long term follow up |
| topic | Eye Malignant Neoplasm Uveal Melanoma Second primary carcinoma |
| url | https://doi.org/10.1186/s12886-023-03246-z |
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