The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign Bodies
The aim of this study was to investigate the expression patterns of miRNA-let 7a, 7b, and 7c in bronchoalveolar lavage fluid in infants with asthma and airway foreign bodies. Between January 2016 and February 2017, 27 infants were included and divided into observation group (infants with asthma, n =...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-01-01
|
| Series: | Journal of Evidence-Based Integrative Medicine |
| Online Access: | https://doi.org/10.1177/2515690X18821906 |
| _version_ | 1819289356741902336 |
|---|---|
| author | Hang-Hu Zhang MS Cai-Xue Li MS Lan-Fang Tang PhD |
| author_facet | Hang-Hu Zhang MS Cai-Xue Li MS Lan-Fang Tang PhD |
| author_sort | Hang-Hu Zhang MS |
| collection | DOAJ |
| description | The aim of this study was to investigate the expression patterns of miRNA-let 7a, 7b, and 7c in bronchoalveolar lavage fluid in infants with asthma and airway foreign bodies. Between January 2016 and February 2017, 27 infants were included and divided into observation group (infants with asthma, n = 15) and control group (infants with airway foreign bodies, n = 12). The differential expression profiles of miRNA-let 7a, 7b, and 7c were determined by reverse transcription–polymerase chain reaction in bronchoalveolar lavage fluid (BALF) from infants of the 2 groups. The BALF was collected from infants undergoing flexible bronchoscopy. MiRNA-let 7a, 7b, and 7c increased significantly in infants from observation group as compared with control group (2.72 ± 0.48 vs 1, 8.23 ± 1.64 vs 1, 3.16 ± 0.62 vs 1, respectively). The increased expression of miRNA-let 7a, 7b, and 7c were associated with the asthma of infants. |
| first_indexed | 2024-12-24T03:05:33Z |
| format | Article |
| id | doaj.art-cd72541f3bd145629866f7bea62c7f3d |
| institution | Directory Open Access Journal |
| issn | 2515-690X |
| language | English |
| last_indexed | 2024-12-24T03:05:33Z |
| publishDate | 2019-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Evidence-Based Integrative Medicine |
| spelling | doaj.art-cd72541f3bd145629866f7bea62c7f3d2022-12-21T17:18:01ZengSAGE PublishingJournal of Evidence-Based Integrative Medicine2515-690X2019-01-012410.1177/2515690X18821906The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign BodiesHang-Hu Zhang MS0Cai-Xue Li MS1Lan-Fang Tang PhD2 Shaoxing People’s Hospital, Shaoxing, China Hangzhou Children’s Hospital, Hangzhou, China The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaThe aim of this study was to investigate the expression patterns of miRNA-let 7a, 7b, and 7c in bronchoalveolar lavage fluid in infants with asthma and airway foreign bodies. Between January 2016 and February 2017, 27 infants were included and divided into observation group (infants with asthma, n = 15) and control group (infants with airway foreign bodies, n = 12). The differential expression profiles of miRNA-let 7a, 7b, and 7c were determined by reverse transcription–polymerase chain reaction in bronchoalveolar lavage fluid (BALF) from infants of the 2 groups. The BALF was collected from infants undergoing flexible bronchoscopy. MiRNA-let 7a, 7b, and 7c increased significantly in infants from observation group as compared with control group (2.72 ± 0.48 vs 1, 8.23 ± 1.64 vs 1, 3.16 ± 0.62 vs 1, respectively). The increased expression of miRNA-let 7a, 7b, and 7c were associated with the asthma of infants.https://doi.org/10.1177/2515690X18821906 |
| spellingShingle | Hang-Hu Zhang MS Cai-Xue Li MS Lan-Fang Tang PhD The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign Bodies Journal of Evidence-Based Integrative Medicine |
| title | The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign Bodies |
| title_full | The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign Bodies |
| title_fullStr | The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign Bodies |
| title_full_unstemmed | The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign Bodies |
| title_short | The Differential Expression Profiles of miRNA-let 7a, 7b, and 7c in Bronchoalveolar Lavage Fluid From Infants With Asthma and Airway Foreign Bodies |
| title_sort | differential expression profiles of mirna let 7a 7b and 7c in bronchoalveolar lavage fluid from infants with asthma and airway foreign bodies |
| url | https://doi.org/10.1177/2515690X18821906 |
| work_keys_str_mv | AT hanghuzhangms thedifferentialexpressionprofilesofmirnalet7a7band7cinbronchoalveolarlavagefluidfrominfantswithasthmaandairwayforeignbodies AT caixuelims thedifferentialexpressionprofilesofmirnalet7a7band7cinbronchoalveolarlavagefluidfrominfantswithasthmaandairwayforeignbodies AT lanfangtangphd thedifferentialexpressionprofilesofmirnalet7a7band7cinbronchoalveolarlavagefluidfrominfantswithasthmaandairwayforeignbodies AT hanghuzhangms differentialexpressionprofilesofmirnalet7a7band7cinbronchoalveolarlavagefluidfrominfantswithasthmaandairwayforeignbodies AT caixuelims differentialexpressionprofilesofmirnalet7a7band7cinbronchoalveolarlavagefluidfrominfantswithasthmaandairwayforeignbodies AT lanfangtangphd differentialexpressionprofilesofmirnalet7a7band7cinbronchoalveolarlavagefluidfrominfantswithasthmaandairwayforeignbodies |