Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation?
BackgroundTheoretically, L-type calcium channel blockers could modulate anesthetic effects. Nicardipine does not affect the bispectral index (BIS), but nimodipine, which can penetrate the blood-brain barrier, has not been studied. The aim of this study was to evaluate whether a single dose of intrav...
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Korean Society of Anesthesiologists
2010-10-01
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| Series: | Korean Journal of Anesthesiology |
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| Online Access: | http://ekja.org/upload/pdf/kjae-59-256.pdf |
| _version_ | 1818417235048267776 |
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| author | Jeong Jin Lee Jie Ae Kim Hyun Joo Ahn Jin-Kyoung Kim Mikyung Yang Soo Joo Choi Hyun-Soo Kim Soo Hyun Yang |
| author_facet | Jeong Jin Lee Jie Ae Kim Hyun Joo Ahn Jin-Kyoung Kim Mikyung Yang Soo Joo Choi Hyun-Soo Kim Soo Hyun Yang |
| author_sort | Jeong Jin Lee |
| collection | DOAJ |
| description | BackgroundTheoretically, L-type calcium channel blockers could modulate anesthetic effects. Nicardipine does not affect the bispectral index (BIS), but nimodipine, which can penetrate the blood-brain barrier, has not been studied. The aim of this study was to evaluate whether a single dose of intravenous nicardipine or nimodipine could affect BIS following rapid sequence intubation.MethodsThis study was done in a double-blind, randomized fashion. Anesthesia was induced with fentanyl 2 µg/kg, thiopental sodium 5 mg/kg, and 100% oxygen. After loss of consciousness, patients received rocuronium 1.0 mg/kg and either a bolus of 20 µg/kg nicardipine, nimodipine, or a comparable volume of normal saline (n = 20). Intubation was performed 1 min after study drug administration. BIS, mean blood pressure (MBP), and heart rate (HR) were measured before anesthetic induction, after loss of consciousness, before intubation, during intubation, and 1, 2 and 5 min after intubation.ResultsBIS dropped rapidly after induction but increased to 60 before intubation in all groups irrespective of study drug. In nimodipine, the increase in BIS during intubation was not significant compared to pre-intubation, in contrast to the other two groups, but there was no difference in BIS during intubation. HR significantly increased, but MBP just rose to pre-induction values after intubation in nicardipine and nimodipine groups. BIS, MBP, and HR following intubation increased in control group.ConclusionsA single dose of intravenous nicardipine or nimodipine could attenuate blood pressure increases but not affect BIS increases in rapid sequence intubation. |
| first_indexed | 2024-12-14T12:03:33Z |
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| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-14T12:03:33Z |
| publishDate | 2010-10-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-cd7447d9984247bfac43a9d610fe07562022-12-21T23:01:55ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632010-10-0159425625910.4097/kjae.2010.59.4.2566959Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation?Jeong Jin Lee0Jie Ae Kim1Hyun Joo Ahn2Jin-Kyoung Kim3Mikyung Yang4Soo Joo Choi5Hyun-Soo Kim6Soo Hyun Yang7Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.BackgroundTheoretically, L-type calcium channel blockers could modulate anesthetic effects. Nicardipine does not affect the bispectral index (BIS), but nimodipine, which can penetrate the blood-brain barrier, has not been studied. The aim of this study was to evaluate whether a single dose of intravenous nicardipine or nimodipine could affect BIS following rapid sequence intubation.MethodsThis study was done in a double-blind, randomized fashion. Anesthesia was induced with fentanyl 2 µg/kg, thiopental sodium 5 mg/kg, and 100% oxygen. After loss of consciousness, patients received rocuronium 1.0 mg/kg and either a bolus of 20 µg/kg nicardipine, nimodipine, or a comparable volume of normal saline (n = 20). Intubation was performed 1 min after study drug administration. BIS, mean blood pressure (MBP), and heart rate (HR) were measured before anesthetic induction, after loss of consciousness, before intubation, during intubation, and 1, 2 and 5 min after intubation.ResultsBIS dropped rapidly after induction but increased to 60 before intubation in all groups irrespective of study drug. In nimodipine, the increase in BIS during intubation was not significant compared to pre-intubation, in contrast to the other two groups, but there was no difference in BIS during intubation. HR significantly increased, but MBP just rose to pre-induction values after intubation in nicardipine and nimodipine groups. BIS, MBP, and HR following intubation increased in control group.ConclusionsA single dose of intravenous nicardipine or nimodipine could attenuate blood pressure increases but not affect BIS increases in rapid sequence intubation.http://ekja.org/upload/pdf/kjae-59-256.pdfbisintubationnicardipinenimodipine |
| spellingShingle | Jeong Jin Lee Jie Ae Kim Hyun Joo Ahn Jin-Kyoung Kim Mikyung Yang Soo Joo Choi Hyun-Soo Kim Soo Hyun Yang Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation? Korean Journal of Anesthesiology bis intubation nicardipine nimodipine |
| title | Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation? |
| title_full | Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation? |
| title_fullStr | Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation? |
| title_full_unstemmed | Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation? |
| title_short | Does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation? |
| title_sort | does a single dose of intravenous nicardipine or nimodipine affect the bispectral index following rapid sequence intubation |
| topic | bis intubation nicardipine nimodipine |
| url | http://ekja.org/upload/pdf/kjae-59-256.pdf |
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