An Orally Administrated Hyaluronan Functionalized Polymeric Hybrid Nanoparticle System for Colon-Specific Drug Delivery
There is a pressing clinical need for advanced colon-specific local drug delivery systems that can provide major advantages in treating diseases associated with the colon, such as inflammatory bowel disease (IBD) and colon cancer. A precise colon targeted drug delivery platform is expected to reduce...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/9/9/1246 |
| _version_ | 1819131580282568704 |
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| author | Niranjan G. Kotla Orla Burke Abhay Pandit Yury Rochev |
| author_facet | Niranjan G. Kotla Orla Burke Abhay Pandit Yury Rochev |
| author_sort | Niranjan G. Kotla |
| collection | DOAJ |
| description | There is a pressing clinical need for advanced colon-specific local drug delivery systems that can provide major advantages in treating diseases associated with the colon, such as inflammatory bowel disease (IBD) and colon cancer. A precise colon targeted drug delivery platform is expected to reduce drug side effects and increase the therapeutic response at the intended disease site locally. In this study, we report the fabrication of hyaluronan (HA) functionalized polymeric hybrid nanoparticulate system (Cur-HA NPs) by using curcumin as a model fluorescent drug. The Cur-HA NPs were about 200−300 nm in size, −51.3 mV overall surface charge after HA functionalization, with 56.0% drug released after 72 h in simulated gastrointestinal fluids. The Cur-HA NPs did not exhibit any cytotoxicity by AlamarBlue, PicoGreen and Live/Dead assays. Following the Cur-HA NPs use on HT-29 monolayer cell cultures demonstrating, the efficacy of HA functionalization increases cellular interaction, uptake when compared to uncoated nanoparticulate system. These findings indicate that HA functionalized nano-hybrid particles are effective in delivering drugs orally to the lower gastrointestinal tract (GIT) in order to treat local colonic diseases. |
| first_indexed | 2024-12-22T09:17:46Z |
| format | Article |
| id | doaj.art-cd7569ad42de40758df9a82cb7a504bf |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-22T09:17:46Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-cd7569ad42de40758df9a82cb7a504bf2022-12-21T18:31:16ZengMDPI AGNanomaterials2079-49912019-09-0199124610.3390/nano9091246nano9091246An Orally Administrated Hyaluronan Functionalized Polymeric Hybrid Nanoparticle System for Colon-Specific Drug DeliveryNiranjan G. Kotla0Orla Burke1Abhay Pandit2Yury Rochev3Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway, Galway H91 W2TY, IrelandCentre for Research in Medical Devices (CÚRAM), National University of Ireland Galway, Galway H91 W2TY, IrelandCentre for Research in Medical Devices (CÚRAM), National University of Ireland Galway, Galway H91 W2TY, IrelandCentre for Research in Medical Devices (CÚRAM), National University of Ireland Galway, Galway H91 W2TY, IrelandThere is a pressing clinical need for advanced colon-specific local drug delivery systems that can provide major advantages in treating diseases associated with the colon, such as inflammatory bowel disease (IBD) and colon cancer. A precise colon targeted drug delivery platform is expected to reduce drug side effects and increase the therapeutic response at the intended disease site locally. In this study, we report the fabrication of hyaluronan (HA) functionalized polymeric hybrid nanoparticulate system (Cur-HA NPs) by using curcumin as a model fluorescent drug. The Cur-HA NPs were about 200−300 nm in size, −51.3 mV overall surface charge after HA functionalization, with 56.0% drug released after 72 h in simulated gastrointestinal fluids. The Cur-HA NPs did not exhibit any cytotoxicity by AlamarBlue, PicoGreen and Live/Dead assays. Following the Cur-HA NPs use on HT-29 monolayer cell cultures demonstrating, the efficacy of HA functionalization increases cellular interaction, uptake when compared to uncoated nanoparticulate system. These findings indicate that HA functionalized nano-hybrid particles are effective in delivering drugs orally to the lower gastrointestinal tract (GIT) in order to treat local colonic diseases.https://www.mdpi.com/2079-4991/9/9/1246colon targeted drug deliveryhyaluronanpolymeric nanoconjugatescurcumininflammatory bowel diseasecolon cancer |
| spellingShingle | Niranjan G. Kotla Orla Burke Abhay Pandit Yury Rochev An Orally Administrated Hyaluronan Functionalized Polymeric Hybrid Nanoparticle System for Colon-Specific Drug Delivery Nanomaterials colon targeted drug delivery hyaluronan polymeric nanoconjugates curcumin inflammatory bowel disease colon cancer |
| title | An Orally Administrated Hyaluronan Functionalized Polymeric Hybrid Nanoparticle System for Colon-Specific Drug Delivery |
| title_full | An Orally Administrated Hyaluronan Functionalized Polymeric Hybrid Nanoparticle System for Colon-Specific Drug Delivery |
| title_fullStr | An Orally Administrated Hyaluronan Functionalized Polymeric Hybrid Nanoparticle System for Colon-Specific Drug Delivery |
| title_full_unstemmed | An Orally Administrated Hyaluronan Functionalized Polymeric Hybrid Nanoparticle System for Colon-Specific Drug Delivery |
| title_short | An Orally Administrated Hyaluronan Functionalized Polymeric Hybrid Nanoparticle System for Colon-Specific Drug Delivery |
| title_sort | orally administrated hyaluronan functionalized polymeric hybrid nanoparticle system for colon specific drug delivery |
| topic | colon targeted drug delivery hyaluronan polymeric nanoconjugates curcumin inflammatory bowel disease colon cancer |
| url | https://www.mdpi.com/2079-4991/9/9/1246 |
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