An Autocrine Negative Feedback Loop Inhibits Dictyostelium discoideum Proliferation through Pathways Including IP3/Ca <sup>2+</sup>
Many mammalian tissues such as the liver have the remarkable ability to regulate their size and have their cells stop proliferating when the tissue reaches the correct size. One possible mechanism involves the cells secreting a signal that they all sense, and a high level of the signal tells the cel...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2021-06-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.01347-21 |
| _version_ | 1818881484536152064 |
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| author | Yu Tang Ramesh Rijal David E. Zimmerhanzel Jacquelyn R. McCullough Louis A. Cadena Richard H. Gomer |
| author_facet | Yu Tang Ramesh Rijal David E. Zimmerhanzel Jacquelyn R. McCullough Louis A. Cadena Richard H. Gomer |
| author_sort | Yu Tang |
| collection | DOAJ |
| description | Many mammalian tissues such as the liver have the remarkable ability to regulate their size and have their cells stop proliferating when the tissue reaches the correct size. One possible mechanism involves the cells secreting a signal that they all sense, and a high level of the signal tells the cells that there are enough of them and to stop proliferating. |
| first_indexed | 2024-12-19T15:02:36Z |
| format | Article |
| id | doaj.art-cd769e08364847d297279543191a45c4 |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-19T15:02:36Z |
| publishDate | 2021-06-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-cd769e08364847d297279543191a45c42022-12-21T20:16:32ZengAmerican Society for MicrobiologymBio2150-75112021-06-0112310.1128/mBio.01347-21An Autocrine Negative Feedback Loop Inhibits Dictyostelium discoideum Proliferation through Pathways Including IP3/Ca <sup>2+</sup>Yu Tang0Ramesh Rijal1David E. Zimmerhanzel2Jacquelyn R. McCullough3Louis A. Cadena4Richard H. Gomer5Department of Biology, Texas A&M University, College Station, Texas, USADepartment of Biology, Texas A&M University, College Station, Texas, USADepartment of Biology, Texas A&M University, College Station, Texas, USADepartment of Biology, Texas A&M University, College Station, Texas, USADepartment of Biology, Texas A&M University, College Station, Texas, USADepartment of Biology, Texas A&M University, College Station, Texas, USAMany mammalian tissues such as the liver have the remarkable ability to regulate their size and have their cells stop proliferating when the tissue reaches the correct size. One possible mechanism involves the cells secreting a signal that they all sense, and a high level of the signal tells the cells that there are enough of them and to stop proliferating.https://journals.asm.org/doi/10.1128/mBio.01347-21 |
| spellingShingle | Yu Tang Ramesh Rijal David E. Zimmerhanzel Jacquelyn R. McCullough Louis A. Cadena Richard H. Gomer An Autocrine Negative Feedback Loop Inhibits Dictyostelium discoideum Proliferation through Pathways Including IP3/Ca <sup>2+</sup> mBio |
| title | An Autocrine Negative Feedback Loop Inhibits Dictyostelium discoideum Proliferation through Pathways Including IP3/Ca
<sup>2+</sup> |
| title_full | An Autocrine Negative Feedback Loop Inhibits Dictyostelium discoideum Proliferation through Pathways Including IP3/Ca
<sup>2+</sup> |
| title_fullStr | An Autocrine Negative Feedback Loop Inhibits Dictyostelium discoideum Proliferation through Pathways Including IP3/Ca
<sup>2+</sup> |
| title_full_unstemmed | An Autocrine Negative Feedback Loop Inhibits Dictyostelium discoideum Proliferation through Pathways Including IP3/Ca
<sup>2+</sup> |
| title_short | An Autocrine Negative Feedback Loop Inhibits Dictyostelium discoideum Proliferation through Pathways Including IP3/Ca
<sup>2+</sup> |
| title_sort | autocrine negative feedback loop inhibits dictyostelium discoideum proliferation through pathways including ip3 ca sup 2 sup |
| url | https://journals.asm.org/doi/10.1128/mBio.01347-21 |
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