Birth Weights in Sickle Cell Disease Pregnancies: A Cohort Study.
Pregnancy in women with Sickle Cell Disease (SCD) has been linked with an increased incidence of adverse foetal outcomes when compared to women without haemoglobinopathies (HbAA). There's a paucity of data into foetal outcomes for infants born to women with SCD. Customised growth charts have be...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5077113?pdf=render |
| _version_ | 1830480019713949696 |
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| author | Daveena Meeks Susan E Robinson David Macleod Eugene Oteng-Ntim |
| author_facet | Daveena Meeks Susan E Robinson David Macleod Eugene Oteng-Ntim |
| author_sort | Daveena Meeks |
| collection | DOAJ |
| description | Pregnancy in women with Sickle Cell Disease (SCD) has been linked with an increased incidence of adverse foetal outcomes when compared to women without haemoglobinopathies (HbAA). There's a paucity of data into foetal outcomes for infants born to women with SCD. Customised growth charts have been demonstrated to be better than population-based growth charts at identifying unhealthy small babies. We analysed the mean birth weight and customised birth weight centiles of infants born to mothers with SCD versus mothers with HbAA genotype, to quantify the risk of having a smaller baby. Birth weight and birth weight centiles were analysed for 88 women with SCD (50 HbSS; 38 HbSC) and 176 controls (HbAA). Statistically significant differences were seen in the mean birth weight (P value = 0.004) and the mean birth weight centiles (P value = 0.016). We conclude that SCD is a risk factor for having a smaller baby. |
| first_indexed | 2024-12-21T16:57:37Z |
| format | Article |
| id | doaj.art-cd7716feb80a4c05b3f505de1b61ecf2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T16:57:37Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cd7716feb80a4c05b3f505de1b61ecf22022-12-21T18:56:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016523810.1371/journal.pone.0165238Birth Weights in Sickle Cell Disease Pregnancies: A Cohort Study.Daveena MeeksSusan E RobinsonDavid MacleodEugene Oteng-NtimPregnancy in women with Sickle Cell Disease (SCD) has been linked with an increased incidence of adverse foetal outcomes when compared to women without haemoglobinopathies (HbAA). There's a paucity of data into foetal outcomes for infants born to women with SCD. Customised growth charts have been demonstrated to be better than population-based growth charts at identifying unhealthy small babies. We analysed the mean birth weight and customised birth weight centiles of infants born to mothers with SCD versus mothers with HbAA genotype, to quantify the risk of having a smaller baby. Birth weight and birth weight centiles were analysed for 88 women with SCD (50 HbSS; 38 HbSC) and 176 controls (HbAA). Statistically significant differences were seen in the mean birth weight (P value = 0.004) and the mean birth weight centiles (P value = 0.016). We conclude that SCD is a risk factor for having a smaller baby.http://europepmc.org/articles/PMC5077113?pdf=render |
| spellingShingle | Daveena Meeks Susan E Robinson David Macleod Eugene Oteng-Ntim Birth Weights in Sickle Cell Disease Pregnancies: A Cohort Study. PLoS ONE |
| title | Birth Weights in Sickle Cell Disease Pregnancies: A Cohort Study. |
| title_full | Birth Weights in Sickle Cell Disease Pregnancies: A Cohort Study. |
| title_fullStr | Birth Weights in Sickle Cell Disease Pregnancies: A Cohort Study. |
| title_full_unstemmed | Birth Weights in Sickle Cell Disease Pregnancies: A Cohort Study. |
| title_short | Birth Weights in Sickle Cell Disease Pregnancies: A Cohort Study. |
| title_sort | birth weights in sickle cell disease pregnancies a cohort study |
| url | http://europepmc.org/articles/PMC5077113?pdf=render |
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