Prevalence of Cytomegalovirus infection among Egyptian patients with fever of unknown origin
Background: Diagnosis of prolonged febrile illness of unknown origin (FUO) is challenging even with the advances in the diagnostic techniques. As common as the infection with cytomegalovirus (CMV) is, most health care providers would not suspect CMV infection as a cause of FUO unless mononucleosis s...
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| Format: | Article |
| Language: | English |
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Zagazig University, Faculty of Medicine
2022-08-01
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| Series: | Microbes and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mid.journals.ekb.eg/article_245959_ad5c38e99e6d7f5c4492790c2165d3b6.pdf |
| _version_ | 1811204948072857600 |
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| author | Mahmoud Zeinhom amal jouda ahmed gad Mostafa Elnakib |
| author_facet | Mahmoud Zeinhom amal jouda ahmed gad Mostafa Elnakib |
| author_sort | Mahmoud Zeinhom |
| collection | DOAJ |
| description | Background: Diagnosis of prolonged febrile illness of unknown origin (FUO) is challenging even with the advances in the diagnostic techniques. As common as the infection with cytomegalovirus (CMV) is, most health care providers would not suspect CMV infection as a cause of FUO unless mononucleosis syndrome is evident. The aim of this study is to investigate the rate of CMV infection among patients with FUO and shed light on IgG avidity as a diagnostic tool. Patients and methods: Two hundred and twenty three (223) immune competent patients with FUO were included in our study. They were subjected to all routine laboratory investigations, fever agglutinins, tuberculin and abdominal ultrasound along with IgG and IgM for CMV and IgG avidity test. Results: This study shows that the 92.8% of the overall studied population were positive for CMV IgG. However, only 74(33.2%) of the studied population was found positive for IgM. Only one patient had positive IgM with negative IgG. IgG avidity was high in almost all of them. Only 3 patients showed low IgG avidity denoting that they have primary infection. Conclusion: CMV infection was found to be the cause of 33.2% of prolonged febrile illness experienced by immuncompetent adults. Only 1.8% of patients had primary CMV infection and the majority of them had detectable IgG level and were diagnosed with primary infection depending mainly on IgG avidity test. |
| first_indexed | 2024-04-12T03:22:19Z |
| format | Article |
| id | doaj.art-cd784887f8974c6da5429d04c1f42b8a |
| institution | Directory Open Access Journal |
| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-04-12T03:22:19Z |
| publishDate | 2022-08-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-cd784887f8974c6da5429d04c1f42b8a2022-12-22T03:49:52ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402022-08-013358859510.21608/mid.2022.136908.1311245959Prevalence of Cytomegalovirus infection among Egyptian patients with fever of unknown originMahmoud Zeinhom0amal jouda1ahmed gad2Mostafa Elnakib3resident of tropical medicine in Military fever hospitaltropical medicine department, faculty of medicine , Zagazig universitylecturer of microbiology, military medical academyEgypt center for research and regenerative medicine, ECRRM, Cairo, 11517, Egypt.Background: Diagnosis of prolonged febrile illness of unknown origin (FUO) is challenging even with the advances in the diagnostic techniques. As common as the infection with cytomegalovirus (CMV) is, most health care providers would not suspect CMV infection as a cause of FUO unless mononucleosis syndrome is evident. The aim of this study is to investigate the rate of CMV infection among patients with FUO and shed light on IgG avidity as a diagnostic tool. Patients and methods: Two hundred and twenty three (223) immune competent patients with FUO were included in our study. They were subjected to all routine laboratory investigations, fever agglutinins, tuberculin and abdominal ultrasound along with IgG and IgM for CMV and IgG avidity test. Results: This study shows that the 92.8% of the overall studied population were positive for CMV IgG. However, only 74(33.2%) of the studied population was found positive for IgM. Only one patient had positive IgM with negative IgG. IgG avidity was high in almost all of them. Only 3 patients showed low IgG avidity denoting that they have primary infection. Conclusion: CMV infection was found to be the cause of 33.2% of prolonged febrile illness experienced by immuncompetent adults. Only 1.8% of patients had primary CMV infection and the majority of them had detectable IgG level and were diagnosed with primary infection depending mainly on IgG avidity test.https://mid.journals.ekb.eg/article_245959_ad5c38e99e6d7f5c4492790c2165d3b6.pdfcytomegalovirusimmunoglobulinsagglutininsig g avidity |
| spellingShingle | Mahmoud Zeinhom amal jouda ahmed gad Mostafa Elnakib Prevalence of Cytomegalovirus infection among Egyptian patients with fever of unknown origin Microbes and Infectious Diseases cytomegalovirus immunoglobulins agglutinins ig g avidity |
| title | Prevalence of Cytomegalovirus infection among Egyptian patients with fever of unknown origin |
| title_full | Prevalence of Cytomegalovirus infection among Egyptian patients with fever of unknown origin |
| title_fullStr | Prevalence of Cytomegalovirus infection among Egyptian patients with fever of unknown origin |
| title_full_unstemmed | Prevalence of Cytomegalovirus infection among Egyptian patients with fever of unknown origin |
| title_short | Prevalence of Cytomegalovirus infection among Egyptian patients with fever of unknown origin |
| title_sort | prevalence of cytomegalovirus infection among egyptian patients with fever of unknown origin |
| topic | cytomegalovirus immunoglobulins agglutinins ig g avidity |
| url | https://mid.journals.ekb.eg/article_245959_ad5c38e99e6d7f5c4492790c2165d3b6.pdf |
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