Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform
As the sixth leading cause of cancer death, esophageal cancer is threatening the life of people worldwide. Traditional treatments, such as surgery, chemotherapy, radiotherapy, are facing always augmented challenges including invasion, multidrug resistance (MDR), off-target toxicity. Chemo &...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222008952 |
| _version_ | 1811214489400377344 |
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| author | Guodong Ren ZiCheng Wang Yafei Tian Jinyao Li Yingyu Ma Liang Zhou Chengwu Zhang Lixia Guo Haipeng Diao Lihong Li Li Lu Sufang Ma Zhifang Wu Lili Yan Wen Liu |
| author_facet | Guodong Ren ZiCheng Wang Yafei Tian Jinyao Li Yingyu Ma Liang Zhou Chengwu Zhang Lixia Guo Haipeng Diao Lihong Li Li Lu Sufang Ma Zhifang Wu Lili Yan Wen Liu |
| author_sort | Guodong Ren |
| collection | DOAJ |
| description | As the sixth leading cause of cancer death, esophageal cancer is threatening the life of people worldwide. Traditional treatments, such as surgery, chemotherapy, radiotherapy, are facing always augmented challenges including invasion, multidrug resistance (MDR), off-target toxicity. Chemo & Photodynamic synergistic therapy represents one promising strategy for improved treatment efficiency. But it is still hindered by the lack of tumor targeting, deleterious side effects, and unfavorable microenvironment for photodynamic therapy (PDT). To overcome those obstacles, one theranostic nano-assambly drug, GCDs-Ce6/Pt-EGF, was designed and fabricated. Green fluorescence carbon dots (GCDs) with the excellent optical properties, modifiability and low toxicity were prepared as drug carrier. Epidermal growth factor (EGF) was conjugated to the nano-assembly to realize tumor specific targeting. Chlorin e6 (Ce6) in the presence of laser irradiation achieved PDT by generating proapoptosis reactive oxygen species (ROS). Moreover, Ce6 incorporated into GCDs endowed the nano-assambly imaging ability and facilitate image-guided therapy. Pt(IV), cisplatin prodrug, in the nano-assambly depleted the glutathione (GSH) of tumor microenvironment when it was reduced to cytotoxicity Pt(II). Compared with single treatment, GCDs-Ce6/Pt-EGF exhibited enhanced tumor cell killing capacity and better biosafety in vitro and in vivo, especially for EGFR bearing tumor. It paved ways for developing novel theranostic agent to be potentially applied in clinic. |
| first_indexed | 2024-04-12T06:05:26Z |
| format | Article |
| id | doaj.art-cd7a261822f04149ac786b1d11fc0ac9 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-12T06:05:26Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-cd7a261822f04149ac786b1d11fc0ac92022-12-22T03:44:54ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-09-01153113506Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatformGuodong Ren0ZiCheng Wang1Yafei Tian2Jinyao Li3Yingyu Ma4Liang Zhou5Chengwu Zhang6Lixia Guo7Haipeng Diao8Lihong Li9Li Lu10Sufang Ma11Zhifang Wu12Lili Yan13Wen Liu14College of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China; Key laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan 030001, PR China; Corresponding authors at: College of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China.College of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China; Key laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China; Corresponding author.College of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR ChinaFirst school of clinical medicine, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR ChinaCollege of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China; First school of clinical medicine, Shanxi Medical University, Taiyuan 030001, PR China; Key laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan 030001, PR China; Corresponding authors at: College of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, PR China.As the sixth leading cause of cancer death, esophageal cancer is threatening the life of people worldwide. Traditional treatments, such as surgery, chemotherapy, radiotherapy, are facing always augmented challenges including invasion, multidrug resistance (MDR), off-target toxicity. Chemo & Photodynamic synergistic therapy represents one promising strategy for improved treatment efficiency. But it is still hindered by the lack of tumor targeting, deleterious side effects, and unfavorable microenvironment for photodynamic therapy (PDT). To overcome those obstacles, one theranostic nano-assambly drug, GCDs-Ce6/Pt-EGF, was designed and fabricated. Green fluorescence carbon dots (GCDs) with the excellent optical properties, modifiability and low toxicity were prepared as drug carrier. Epidermal growth factor (EGF) was conjugated to the nano-assembly to realize tumor specific targeting. Chlorin e6 (Ce6) in the presence of laser irradiation achieved PDT by generating proapoptosis reactive oxygen species (ROS). Moreover, Ce6 incorporated into GCDs endowed the nano-assambly imaging ability and facilitate image-guided therapy. Pt(IV), cisplatin prodrug, in the nano-assambly depleted the glutathione (GSH) of tumor microenvironment when it was reduced to cytotoxicity Pt(II). Compared with single treatment, GCDs-Ce6/Pt-EGF exhibited enhanced tumor cell killing capacity and better biosafety in vitro and in vivo, especially for EGFR bearing tumor. It paved ways for developing novel theranostic agent to be potentially applied in clinic.http://www.sciencedirect.com/science/article/pii/S0753332222008952Esophageal cancerNano-assemblyEGFR targetingPhotodynamic therapyChemotherapy |
| spellingShingle | Guodong Ren ZiCheng Wang Yafei Tian Jinyao Li Yingyu Ma Liang Zhou Chengwu Zhang Lixia Guo Haipeng Diao Lihong Li Li Lu Sufang Ma Zhifang Wu Lili Yan Wen Liu Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform Biomedicine & Pharmacotherapy Esophageal cancer Nano-assembly EGFR targeting Photodynamic therapy Chemotherapy |
| title | Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform |
| title_full | Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform |
| title_fullStr | Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform |
| title_full_unstemmed | Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform |
| title_short | Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform |
| title_sort | targeted chemo photodynamic therapy toward esophageal cancer by gsh sensitive theranostic nanoplatform |
| topic | Esophageal cancer Nano-assembly EGFR targeting Photodynamic therapy Chemotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222008952 |
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