Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
Breast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis suppressor genes are a group of genes that play a crucial role in preventing or inhibiting the spread of...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Open Exploration Publishing Inc.
2023-10-01
|
| Series: | Exploration of Targeted Anti-tumor Therapy |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/etat/Article/1002173 |
| _version_ | 1797661474601041920 |
|---|---|
| author | Sathammai Sathappa Supuramanian Sid Dsa Sitaram Harihar |
| author_facet | Sathammai Sathappa Supuramanian Sid Dsa Sitaram Harihar |
| author_sort | Sathammai Sathappa Supuramanian |
| collection | DOAJ |
| description | Breast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis suppressor genes are a group of genes that play a crucial role in preventing or inhibiting the spread of cancer cells. They suppress the metastasis process by inhibiting colonization and by inducing dormancy. These genes function by regulating various cellular processes in the tumor microenvironment (TME), such as cell adhesion, invasion, migration, and angiogenesis. Dysregulation of metastasis suppressor genes can lead to the acquisition of an invasive and metastatic phenotype and lead to poor prognostic outcomes. The components of the TME generally play a necessary in the metastasis progression of tumor cells. This review has identified and elaborated on the role of a few metastatic suppressors associated with the TME that have been shown to inhibit metastasis in BC by different mechanisms, such as blocking certain cell signaling molecules involved in cancer cell migration, invasion, enhancing immune surveillance of cancer cells, and promoting the formation of a protective extracellular matrix (ECM). Understanding the interaction of metastatic suppressor genes and the components of TME has important implications for the development of novel therapeutic strategies to target the metastatic cascade. Targeting these genes or their downstream signaling pathways offers a promising approach to inhibiting the spread of cancer cells and improves patient outcomes. |
| first_indexed | 2024-03-11T18:46:01Z |
| format | Article |
| id | doaj.art-cd7b33971c9448efa940ec01644315fc |
| institution | Directory Open Access Journal |
| issn | 2692-3114 |
| language | English |
| last_indexed | 2024-03-11T18:46:01Z |
| publishDate | 2023-10-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Targeted Anti-tumor Therapy |
| spelling | doaj.art-cd7b33971c9448efa940ec01644315fc2023-10-12T01:27:29ZengOpen Exploration Publishing Inc.Exploration of Targeted Anti-tumor Therapy2692-31142023-10-014591293210.37349/etat.2023.00173Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancerSathammai Sathappa Supuramanian0https://orcid.org/0000-0002-5721-5163Sid Dsa1https://orcid.org/0009-0002-7630-656XSitaram Harihar2https://orcid.org/0000-0003-4953-7282Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, IndiaDepartment of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, IndiaDepartment of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, IndiaBreast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis suppressor genes are a group of genes that play a crucial role in preventing or inhibiting the spread of cancer cells. They suppress the metastasis process by inhibiting colonization and by inducing dormancy. These genes function by regulating various cellular processes in the tumor microenvironment (TME), such as cell adhesion, invasion, migration, and angiogenesis. Dysregulation of metastasis suppressor genes can lead to the acquisition of an invasive and metastatic phenotype and lead to poor prognostic outcomes. The components of the TME generally play a necessary in the metastasis progression of tumor cells. This review has identified and elaborated on the role of a few metastatic suppressors associated with the TME that have been shown to inhibit metastasis in BC by different mechanisms, such as blocking certain cell signaling molecules involved in cancer cell migration, invasion, enhancing immune surveillance of cancer cells, and promoting the formation of a protective extracellular matrix (ECM). Understanding the interaction of metastatic suppressor genes and the components of TME has important implications for the development of novel therapeutic strategies to target the metastatic cascade. Targeting these genes or their downstream signaling pathways offers a promising approach to inhibiting the spread of cancer cells and improves patient outcomes.https://www.explorationpub.com/Journals/etat/Article/1002173tumor microenvironmentmetastasis suppressor genesbreast cancerbreast cancer metastasis suppressor 1 |
| spellingShingle | Sathammai Sathappa Supuramanian Sid Dsa Sitaram Harihar Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer Exploration of Targeted Anti-tumor Therapy tumor microenvironment metastasis suppressor genes breast cancer breast cancer metastasis suppressor 1 |
| title | Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
| title_full | Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
| title_fullStr | Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
| title_full_unstemmed | Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
| title_short | Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
| title_sort | molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer |
| topic | tumor microenvironment metastasis suppressor genes breast cancer breast cancer metastasis suppressor 1 |
| url | https://www.explorationpub.com/Journals/etat/Article/1002173 |
| work_keys_str_mv | AT sathammaisathappasupuramanian molecularinteractionofmetastasissuppressorgenesandtumormicroenvironmentinbreastcancer AT siddsa molecularinteractionofmetastasissuppressorgenesandtumormicroenvironmentinbreastcancer AT sitaramharihar molecularinteractionofmetastasissuppressorgenesandtumormicroenvironmentinbreastcancer |