Novel Risk Variants in the Oxytocin Receptor Gene (<i>OXTR</i>) Possibly Linked to and Associated with Familial Type 2 Diabetes
The oxytocin system is well-known for its role in social bonding and reproduction. Recently, the oxytocin system was found to play other metabolic roles such as regulation of food intake, peripheral glucose uptake, and insulin sensitivity. Variants in <i>OXTR</i> gene have been associate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/7/6282 |
| _version_ | 1797607837415768064 |
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| author | Mutaz Amin Rongling Wu Claudia Gragnoli |
| author_facet | Mutaz Amin Rongling Wu Claudia Gragnoli |
| author_sort | Mutaz Amin |
| collection | DOAJ |
| description | The oxytocin system is well-known for its role in social bonding and reproduction. Recently, the oxytocin system was found to play other metabolic roles such as regulation of food intake, peripheral glucose uptake, and insulin sensitivity. Variants in <i>OXTR</i> gene have been associated with overeating, increased cardiovascular risk, and type 2 diabetes (T2D). We tested 20 microarray-derived single nucleotide polymorphisms in the <i>OXTR</i> gene in 212 Italian families with rich family history for T2D and found four novel and one previously reported variant suggestively significant for linkage and association with the risk of T2D. Our study has shed some light into the genetics of susceptibility to T2D at least in Italian families. |
| first_indexed | 2024-03-11T05:36:14Z |
| format | Article |
| id | doaj.art-cd7b45d0bdc94320a9b94c0a82d42f5b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:36:14Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cd7b45d0bdc94320a9b94c0a82d42f5b2023-11-17T16:48:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01247628210.3390/ijms24076282Novel Risk Variants in the Oxytocin Receptor Gene (<i>OXTR</i>) Possibly Linked to and Associated with Familial Type 2 DiabetesMutaz Amin0Rongling Wu1Claudia Gragnoli2French National Institute of Health and Medical Research (INSERM), US14-Orphanet, 75014 Paris, FranceDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USADepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USAThe oxytocin system is well-known for its role in social bonding and reproduction. Recently, the oxytocin system was found to play other metabolic roles such as regulation of food intake, peripheral glucose uptake, and insulin sensitivity. Variants in <i>OXTR</i> gene have been associated with overeating, increased cardiovascular risk, and type 2 diabetes (T2D). We tested 20 microarray-derived single nucleotide polymorphisms in the <i>OXTR</i> gene in 212 Italian families with rich family history for T2D and found four novel and one previously reported variant suggestively significant for linkage and association with the risk of T2D. Our study has shed some light into the genetics of susceptibility to T2D at least in Italian families.https://www.mdpi.com/1422-0067/24/7/6282oxytocinOXToxytocin receptor<i>OXTR</i>type 2 diabetesT2D |
| spellingShingle | Mutaz Amin Rongling Wu Claudia Gragnoli Novel Risk Variants in the Oxytocin Receptor Gene (<i>OXTR</i>) Possibly Linked to and Associated with Familial Type 2 Diabetes International Journal of Molecular Sciences oxytocin OXT oxytocin receptor <i>OXTR</i> type 2 diabetes T2D |
| title | Novel Risk Variants in the Oxytocin Receptor Gene (<i>OXTR</i>) Possibly Linked to and Associated with Familial Type 2 Diabetes |
| title_full | Novel Risk Variants in the Oxytocin Receptor Gene (<i>OXTR</i>) Possibly Linked to and Associated with Familial Type 2 Diabetes |
| title_fullStr | Novel Risk Variants in the Oxytocin Receptor Gene (<i>OXTR</i>) Possibly Linked to and Associated with Familial Type 2 Diabetes |
| title_full_unstemmed | Novel Risk Variants in the Oxytocin Receptor Gene (<i>OXTR</i>) Possibly Linked to and Associated with Familial Type 2 Diabetes |
| title_short | Novel Risk Variants in the Oxytocin Receptor Gene (<i>OXTR</i>) Possibly Linked to and Associated with Familial Type 2 Diabetes |
| title_sort | novel risk variants in the oxytocin receptor gene i oxtr i possibly linked to and associated with familial type 2 diabetes |
| topic | oxytocin OXT oxytocin receptor <i>OXTR</i> type 2 diabetes T2D |
| url | https://www.mdpi.com/1422-0067/24/7/6282 |
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